Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(30)
Published: Aug. 29, 2024
Postoperative
breast
cancer
recurrence
is
tricky
due
to
the
limited
therapeutic
options.
Transforming
growth
factors-β
(TGF-β)
vital
in
promoting
postoperative
tumor
recurrence.
However,
conventional
blocking
strategies
fail
satisfy
both
bio-safety
and
sufficient
relapse
correction.
Neutrophil
extracellular
traps
(NETs)
are
essential
for
spatiotemporal
dynamics
of
TGF-β
at
tumor-resection
sites,
whose
unique
mechanism
local
amplification
could
remarkably
increase
risk
after
surgery.
Herein,
principle
NETs
formation
ingeniously
utilized
construct
a
surgical
residual
cavity
hydrogel
that
mimics
formation.
The
prepared
based
on
electrostatic
interaction
between
histidine
(His)
sodium
alginate
(Alg).
Then,
arginine
deiminase
4
(PAD4)
protein
released
during
Simultaneously,
electrical
property
His
changes
automatically,
which
further
lead
promising
localized
release
anti-TGF-β.
system
can
realize
specific
selective
drug
targeted
site
over
prolonged
period
while
exhibiting
excellent
biocompatibility.
Superior
inhibition
achieved
by
suppressing
related
indicators,
impeding
epithelial-mesenchymal
transition
(EMT)
progression,
rectifying
locally
exacerbated
immunosuppressive
environment
within
NETs.
novel
microenvironment
functional
will
provide
inspiration
correction
strategies.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(9), P. 3674 - 3692
Published: Jan. 1, 2024
Trophoblast
cell
surface
antigen
2
(Trop2)
is
overexpressed
in
a
range
of
solid
tumors
and
participants
multiple
oncogenic
signaling
pathways,
making
it
an
attractive
therapeutic
target.
In
the
past
decade,
rapid
development
various
Trop2-targeted
therapies,
notably
marked
by
advent
antibody-drug
conjugate
(ADC),
revolutionized
outcome
for
patients
facing
Trop2-positive
with
limited
treatment
opinions,
such
as
triple-negative
breast
cancer
(TNBC).
This
review
provides
comprehensive
summary
advances
including
ADCs,
antibodies,
multispecific
agents,
immunotherapy,
vaccines,
small
molecular
inhibitors,
along
in-depth
discussions
on
their
designs,
mechanisms
action
(MOAs),
limitations.
Additionally,
we
emphasize
clinical
research
progress
these
emerging
focusing
application
efficacy
against
tumors.
Furthermore,
propose
directions
future
research,
enhancing
our
understanding
Trop2's
structure
biology,
exploring
best
combination
strategies,
tailoring
precision
based
Trop2
testing
methodologies.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(25), P. 6091 - 6101
Published: Jan. 1, 2024
Due
to
the
rapid
progression
and
aggressive
metastasis
of
breast
cancer,
its
diagnosis
treatment
remain
a
great
challenge.
The
simultaneous
inhibition
tumor
growth
is
necessary
for
cancer
obtain
ideal
therapeutic
outcomes.
We
herein
report
development
radioactive
hybrid
semiconducting
polymer
nanoparticles
(SPNH)
imaging-guided
tri-modal
therapy
cancer.
Two
polymers
are
used
form
SPNH
with
diameter
around
60
nm
via
nano-coprecipitation
they
also
labeled
iodine-131
(131I)
enhance
imaging
functions.
formed
show
good
radiolabeling
stability
excellent
photodynamic
photothermal
effects
under
808
laser
irradiation
produce
singlet
oxygen
(1O2)
heat.
Moreover,
can
generate
1O2
ultrasound
their
sonodynamic
properties.
After
intravenous
tail
vein
injection,
effectively
accumulate
in
subcutaneous
4T1
tumors
living
mice
as
verified
fluorescence
single
photon
emission
computed
tomography
(SPECT)
imaging.
With
using
an
US,
mediate
(PDT),
(PTT)
(SDT)
kill
cells.
Such
leads
improved
efficacy
inhibiting
suppressing
compared
sole
SDT
combinational
PDT-PTT.
This
study
thus
demonstrates
applications
diagnose
combine
different
therapies
effective
treatment.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 1367 - 1382
Published: Feb. 1, 2025
Abstract:
Breast
cancer
remains
a
significant
therapeutic
challenge,
with
the
immune
microenvironment
playing
crucial
role
in
its
progression
and
treatment
response.
This
review
investigates
potential
of
nanoparticles
to
modulate
breast
therapy.
Initially,
we
discuss
composition
influence
on
cancer,
followed
by
current
strategies
targeting
these
components.
We
then
provide
for
cells
such
as
macrophages,
dendritic
cells,
T-cells.
The
enhancing
checkpoint
blockade
(ICB)
their
application
vaccines
is
also
examined.
Additionally,
explore
synergistic
effects
combining
conventional
therapies.
addresses
challenges
clinical
translation,
focusing
safety,
biocompatibility,
toxicity.
Finally,
outline
future
research
directions
advancements
nanoparticle-based
immunotherapy,
emphasizing
transformative
impact
treatment.
Keywords:
nanoparticle,
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 19, 2025
Complete
surgical
resection
of
advanced
breast
cancer
is
highly
challenging
and
often
leaves
behind
microscopic
tumor
foci,
leading
to
inevitable
relapse.
Postoperative
formation
the
immunosuppressive
microenvironment
(TME)
reduces
efficacy
immunotherapies
against
residual
tumors.
Although
cytotoxic
chemotherapeutics
exert
capacity
intensify
immunotherapy
via
immunogenic
cell
death
(ICD)
effects,
systemically
administered
chemo
agents
cannot
access
sites,
fail
elicit
antitumor
immune
responses.
Herein,
we
present
a
novel
syringeable
immunotherapeutic
hydrogel
(SiGel@SN38/aOX40)
loaded
with
DNA-targeting
chemotherapeutic
7-ethyl-10-hydroxycamptothecin
(SN38)
anti-OX40
agonist
antibody
(aOX40).
The
sustained
in-site
release
SN38
aOX40
activate
stimulator
interferon
genes
(STING)
pathway,
type
I
interferons
expression,
synergistically
facilitate
dendritic
(DC)
activation,
initiate
persistent
T
mediated
responses
within
bed
that
eliminate
tumors
no
recurrence
in
120
days.
Collectively,
our
designed
SiGel@SN38/aOX40
induces
robust
long-lasting
tumoricidal
immunity
following
exhibit
immense
potential
for
clinical
translation.
MedComm – Biomaterials and Applications,
Journal Year:
2025,
Volume and Issue:
4(2)
Published: May 5, 2025
ABSTRACT
Breast
cancer
(BCa)
remains
a
significant
health
challenge
worldwide,
with
high
propensity
for
early
metastasis
and
poor
prognosis.
While
surgery,
chemotherapy,
radiotherapy
are
fundamental
managing
BCa,
severe
side
effects,
such
as
low
patient
adherence
suboptimal
survival
outcomes,
cause
concern.
Therefore,
there
is
critical
need
to
innovate
new
approaches
that
facilitate
detection,
accurate
diagnosis,
more
effective
treatment
strategies
BCa.
Nanotechnological
have
been
introduced
the
diagnosis
of
various
cancers,
especially
The
current
review
aims
emphasize
highlight
possible
applications
nanomedicine
in
efficient
Nanocarriers
can
deliver
chemotherapeutic
agents,
enhancing
cytotoxicity
against
BCa
cells
preventing
development
drug
resistance.
Nanoparticles
also
boost
efficacy
gene
therapy
which
promotes
their
potential
regulating
expression.
co‐delivery
drugs
genes
by
nanoparticles
synergistic
effect
on
remodel
tumor
microenvironment.
In
this
review,
we
discussed
latest
advances
application
nanomedicines
diagnosing
treating
Current
research
highlights
benefits
over
traditional
further
efforts
translate
these
findings
into
clinical
practice
