In situ construction of heterojunctions to regulate the biodegradation behavior of copper carriers for tumor-specific cuproptosis-enhanced sono-immunotherapy

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 25, 2025

Cuproptosis, a novel approach utilizing copper carriers to trigger programmed cell death, exhibits promise for enhancing traditional therapies and activating robust adaptive immune responses. However, the uncontrolled release of Cu ions risks triggering cuproptosis in healthy tissues, potentially causing irreversible damage. To address this, we report on use Cu-MOF (copper metal-organic framework) protective layer regulate biodegradation copper-based nanomaterials. In situ formation Cu2O nanocubes not only stabilizes material under physiological conditions but also enhances its sonodynamic therapy (SDT) capabilities by establishing Z-Scheme heterojunction. Upon SDT activation, targeted ion at tumor site triggers cascade reactions, generating reactive oxygen species (ROS) via Fenton-like processes depleting glutathione (GSH). This ROS surge, combined with effective cuproptosis, modulates immunosuppressive microenvironment, inducing immunogenic death eliminate primary tumors inhibit metastasis. study offers new paradigm controlled integration SDT, chemodynamic (CDT), immunotherapy, achieving precise tumor-targeted treatment nanomaterial degradation.

Language: Английский

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Upconversion Core-Shell Nanoconstructs for Cancer Theragnostics

Published: Jan. 1, 2025

Language: Английский

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Gallic acid modified aminated cellulose integrated polyethyleneimine to construct a phenol-amine chemical network for bonding wood

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 221, P. 119333 - 119333

Published: July 30, 2024

Language: Английский

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Zn/Cu Bi‐Single‐Atom Nanoplatform: Hexagonal Anti‐Tumor Warrior by ROS Amplification for DOX Resistance Reversal and Immune Activation

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract Severe resistance of doxorubicin (DOX) caused by drug efflux and immunosuppression has led to a high treatment failure risk breast cancer (BC). Compared with the single atom nanozymes, bi‐single‐atomic nanozymes obtained through sequential single‐atom synthesis strategy in different spaces same nanomaterial, can significantly improve space utilization efficiency catalytic capacity. In this study, bi‐single‐atom (Zn/Cu‐BSAN‐DOX NPs) are designed reverse BC DOX causing damage mitochondria mesenchymal stem cells (MSCs) 4T1 reactive oxygen species (ROS) amplification. situ H 2 O self‐supply is improved releasing activating nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs). ROS amplification triggered enhanced chemodynamic therapy (CDT) sonodynamic (SDT) Zn/Cu‐BSAN, which efficiently reverses breaking hyaluronic acid (HA) barrier efflux. Furthermore, promotes immune improvement including DCs maturation, T cell activation, polarization M1 macrophage. summary, as “hexagonal” anti‐tumor warrior, Zn/Cu‐BSAN‐DOX NPs show great potential for multimodal DOX‐resistant therapy, further expands new preparation clinical application paradigm nanozymes.

Language: Английский

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Recent progress of advanced Nanozymes for targeted oncotherapy and synergistic immunotherapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 536, P. 216674 - 216674

Published: April 5, 2025

Language: Английский

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Carboxymethyl cellulose-coated iron-doped hollow silica carriers with erythrocyte-like structure for improved foliar adhesion and responsive pesticide delivery

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135945 - 135945

Published: Sept. 24, 2024

Language: Английский

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The immunoglobulin of yolk and cerium oxide-based fibrous poly(L-lactide-co-glycolide)/gelatin dressings enable skin regeneration in an infectious wound model

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101408 - 101408

Published: Dec. 18, 2024

Language: Английский

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Peroxidase‐Mimetic Iron Silicate Nanosheets Coordinated with Indocyanine Green for Enhanced Anti‐Tumor Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract The versatile element composition and multifunctional properties of biodegradable silicates have attracted significant attention in cancer therapeutics. However, their application as nanozymes is often limited by suboptimal catalytic efficiency insufficient intratumoral retention. In this study, the hydrothermal synthesis iron silicate (FeSi) nanosheets are reported exhibiting exceptional peroxidase (POD)‐like activity (136.7 U mg −1 ), outperforming most iron‐based nanozymes. Density functional theory calculations revealed that introduction Si into catalyst enhances H 2 O adsorption dissociation Fe sites, leading to superior POD performance. Furthermore, FeSi modified with Indocyanine Green (ICG) facilitate targeted aggregation‐potentiated therapy. integration ICG improved tumor penetration retention nanosheets, significantly increasing reactive oxygen species production bolstering therapeutic efficacy.

Language: Английский

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A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101346 - 101346

Published: Nov. 16, 2024

Language: Английский

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Innovations in Aggregation-Induced Emission Materials for Theranostics in the Musculoskeletal System

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 271, P. 117069 - 117069

Published: Dec. 20, 2024

Language: Английский

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