Tailored Borneol-Modified Lipid Nanoparticles Nasal Spray for Enhanced Nose-to-Brain Delivery to Central Nervous System Diseases DOI
Guanlin Wang,

Zizhao Zhai,

Wenhao Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 23684 - 23701

Published: Aug. 19, 2024

The nanodrug delivery system-based nasal spray (NDDS-NS) can bypass the blood-brain barrier and deliver drugs directly to brain, offering unparalleled advantages in treatment of central nervous system (CNS) diseases. However, current design NNDS-NS is excessively focused on mucosal absorption while neglecting impact deposition nose-to-brain drug delivery, resulting an unsatisfactory efficiency. In this study, effect dispersion medium viscosity NDDS-NS was elucidated. optimized formulation F5 (39.36 mPa·s) demonstrated significantly higher olfactory fraction (ODF) 23.58%, a strong correlation between ODF intracerebral (

Language: Английский

Recent Progress in Nanomedicine for the Diagnosis and Treatment of Alzheimer’s Diseases DOI

Han Yang,

Haozhe Tan,

Haifei Wen

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(50), P. 33792 - 33826

Published: Dec. 3, 2024

Alzheimer's disease (AD) is a neurodegenerative that causes memory loss and progressive permanent deterioration of cognitive function. The most challenging issue in combating AD its complicated pathogenesis, which includes the deposition amyloid β (Aβ) plaques, intracellular hyperphosphorylated tau protein, neurofibrillary tangles (NFT), etc. Despite rapid advancements mechanistic research drug development for AD, currently developed drugs only improve ability temporarily relieve symptoms but cannot prevent AD. Moreover, blood–brain barrier (BBB) creates huge to delivery brain. Therefore, effective diagnostic tools treatments are urgently needed. In recent years, nanomedicine has provided opportunities overcome challenges limitations associated with traditional diagnostics or treatments. Various types nanoparticles (NPs) play an essential role diagnosis treatment acting as carriers targeting bioavailability across/bypass BBB directly on lesions. This review categorizes different NPs summarizes their applications It also discusses clinical explores latest developments prospects

Language: Английский

Citations

4
A solvatochromic carbon dot with turn-on red emissive fluorescence for multi-mode detection of amyloids DOI
Jintao Zhang, J. P. Du,

Minjie Xie

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137537 - 137537

Published: Feb. 1, 2025

Language: Английский

Citations

0
Niobium carbide MXenzyme for targeting disaggregation of human insulin fibrils and anti-inflammation DOI
Yutong Ye, Yongli Ji,

Chunyan Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142542 - 142542

Published: March 1, 2025

Language: Английский

Citations

0
Advancing Nanomaterial-Based Strategies for Alzheimer’s Disease: A Perspective DOI Creative Commons
Hong Zhou, Xiuhua Yin,

G. Y. Zhang

et al.

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, number AD cases projected to exceed 131 million, placing significant strain on healthcare systems economies worldwide. The pathogenesis multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, inflammation. Despite extensive research, complexity these potentially entangled mechanisms has hindered development treatments that can reverse progression. Nanotechnology, leveraging unique physical, electrical, magnetic, optical properties nanomaterials, emerged promising approach for treatment. In this Perspective, we first outlined major current pathogenic hypotheses then reviewed recent advances in nanomaterials addressing hypotheses. We have also discussed challenges translating into clinical applications proposed future directions, particularly multifunctional multitarget enhance their therapeutic efficacy applicability

Language: Английский

Citations

0
Nanoscale drug formulations for the treatment of Alzheimer's disease progression DOI Creative Commons

Liu Liqin,

Haini He,

Bert N. La Du

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(6), P. 4031 - 4078

Published: Jan. 1, 2025

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective disease-modifying treatments.

Language: Английский

Citations

0
Nanomaterial-based approaches to neurotoxin neutralization in neurodegenerative diseases DOI
Meng Cheng, Yan Dou

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 3, 2025

Neurodegenerative diseases (NDs) are intricately linked to the accumulation of various neurotoxins, mainly including toxic proteins, inflammatory mediators, excess metal ions, and viral pathogens. Biological neutralization strategies that use agents competitively bind harmful substances thus inhibit their pathogenic activity hold promise for direct removal neurotoxins but face many limitations challenges in NDs. Nanomaterials provide a potential solution neurotoxin NDs due unique physicochemical biological properties. This review summarizes recent advancements nanomaterial-based approaches NDs, highlighting diverse design principles mechanisms action. We also discuss critical role targeted delivery optimize efficiency advantages combining different or introducing other therapeutic components exert synergistic effects. Furthermore, we reveal current future research directions aimed at paving way nanomedicine development based on treatment

Language: Английский

Citations

0
Biomedical Applications of Gadolinium‐Containing Biomaterials: Not Only MRI Contrast Agent DOI Creative Commons

Xingtong Pan,

Menglong Hu,

Likun Wu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract The potential applications of rare earth elements (REEs) in biomedical fields have been intensively investigated. Numerous studies shown that doping biomaterials with REEs can enhance their properties. Gadolinium (Gd) is a biocompatible REE holds promise applications. This review examines the use Gd‐doped osteogenic, antimicrobial, anticancer applications, and bioimaging bioprobes, as reported literature until December 2024. included demonstrate Gd‐containing promote osteogenesis, antimicrobial properties, perform well bioimaging. Taken together, they point to considerable thus avenues for future research.

Language: Английский

Citations

0
Tailored Borneol-Modified Lipid Nanoparticles Nasal Spray for Enhanced Nose-to-Brain Delivery to Central Nervous System Diseases DOI
Guanlin Wang,

Zizhao Zhai,

Wenhao Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 23684 - 23701

Published: Aug. 19, 2024

The nanodrug delivery system-based nasal spray (NDDS-NS) can bypass the blood-brain barrier and deliver drugs directly to brain, offering unparalleled advantages in treatment of central nervous system (CNS) diseases. However, current design NNDS-NS is excessively focused on mucosal absorption while neglecting impact deposition nose-to-brain drug delivery, resulting an unsatisfactory efficiency. In this study, effect dispersion medium viscosity NDDS-NS was elucidated. optimized formulation F5 (39.36 mPa·s) demonstrated significantly higher olfactory fraction (ODF) 23.58%, a strong correlation between ODF intracerebral (

Language: Английский

Citations

2