Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123379 - 123379
Published: April 1, 2025
Language: Английский
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 612 - 612
Published: May 10, 2024
Overcoming the blood–brain barrier (BBB) remains a significant hurdle in effective drug delivery to brain. While BBB serves as crucial protective barrier, it poses challenges delivering therapeutic agents their intended targets within brain parenchyma. To enhance for treatment of neurological diseases, several technologies circumvent have been developed last few years. Among them, nanoparticles (NPs) are one most versatile and promising tools. Here, we summarize characteristics NPs that facilitate penetration, including size, shape, chemical composition, surface charge, importantly, conjugation with various biological or synthetic molecules such glucose, transferrin, insulin, polyethylene glycol, peptides, aptamers. Additionally, discuss coating surfactants. A comprehensive overview common vitro vivo models NP penetration studies is also provided. The discussion extends discussing impairment under pathological conditions leveraging alterations delivery. Emphasizing need future uncover inherent properties NPs, review advocates role beyond systems calls efforts translating clinic therapeutics. Overall, stand out highly strategy precise targeting disorders.
Language: Английский
Citations
19
Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123138 - 123138
Published: Jan. 28, 2025
Language: Английский
Citations
2
Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 21, 2025
The emerging messenger RNA (mRNA) nanomedicines have sprung up for disease treatment. Developing targeted mRNA has become a thrilling research hotspot in recent years, as they can be precisely delivered to specific organs or tissues enhance efficiency and avoid side effects. Herein, we give comprehensive review on the latest progress of with targeting functions. its carriers are first described detail. Then, mechanisms passive targeting, endogenous active outlined, focus various biological barriers that may encounter during vivo delivery. Next, emphasis is placed summarizing mRNA-based organ-targeting strategies. Lastly, advantages challenges clinical translation mentioned. This expected inspire researchers this field drive further development technology.
Language: Английский
Citations
1
Experimental Neurology, Journal Year: 2024, Volume and Issue: 379, P. 114850 - 114850
Published: June 12, 2024
Language: Английский
Citations
8
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 666, P. 124800 - 124800
Published: Oct. 5, 2024
Language: Английский
Citations
7
BMEMat, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Abstract mRNA therapeutics have significantly evolved within the life sciences, particularly in applications such as vaccines, tumor immunotherapy, protein replacement, gene editing, and monoclonal antibody therapy. To fully realize potential of drugs mitigate adverse effects, substantial vector materials been developed for delivery these pharmaceutical agents. Lipid nanoparticles (LNPs) represent most clinically advanced carriers, recognized by U.S. Food Drug Administration approved vaccines numerous clinical trials. Diverse therapeutic necessitate tailored design LNPs. Herein, we outline principles LNP delivery, focusing specifically on their effectiveness, targeting capabilities, safety profiles, nanoparticle stability. Additionally, present latest advancements mRNA‐LNP technology. This review aims to elucidate benefits systems therapeutics, providing insights into breakthroughs innovative ideas further enhancing advantages. These summaries are dedicated promoting broader LNP‐mRNA drugs, aiming advance treatment serious diseases an effective safe manner.
Language: Английский
Citations
5
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4279 - 4295
Published: May 1, 2024
Ischemic stroke, being a prominent contributor to global disability and mortality, lacks an efficacious therapeutic approach in current clinical settings. Neural stem cells (NSCs) are type of cell that only found inside the nervous system. These can differentiate into various kinds cells, potentially regenerating or restoring neural networks within areas brain have been destroyed. This review begins by providing introduction existing approaches for ischemic followed examination promise limits associated with utilization NSCs treatment stroke. Subsequently, comprehensive overview was conducted synthesize literature on underlying processes cell-derived small extracellular vesicles (NSC-sEVs) transplantation therapy context mechanisms encompass neuroprotection, inflammatory response suppression, endogenous nerve vascular regeneration facilitation. Nevertheless, translation NSC-sEVs is hindered challenges such as inadequate targeting efficacy insufficient content loading. In light these limitations, we compiled advancements utilizing modified treating stroke based methods vesicle modification. conclusion, examining NSC-sEVs-based anticipated be both fundamental applied investigations about
Language: Английский
Citations
4
Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110849 - 110849
Published: Jan. 1, 2025
Language: Английский
Citations
0
Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101436 - 101436
Published: Jan. 23, 2025
Language: Английский
Citations
0
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 4
Published: Jan. 28, 2025
KEYWORDS: Strokenanotherapynanomedicinenanoparticledrug deliverytargeted therapyinflammationoxidative stress
Language: Английский
Citations
0