Versatile Carrier-Free Binary Nanodrugs Based on Metformin/Epigallocatechin Gallate Nanoparticles: Exploring Its Properties and Potential in Cancer Treatment† DOI

Huiyu Zou,

ErKang Bian,

Jinyun He

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Epigallocatechin gallate (EGCG), an important active component extracted from green tea, has attracted much attention due to its multiple biological activities such as antioxidant, antibacterial, anti-inflammatory, and antitumor effects.

Language: Английский

Enhanced mechanical properties of cellulose fiber networks through synergistic effects of telechelic-structured carbohydrate-binding module-modified amphoteric polyacrylamide DOI
Chao Yang,

Yena Liu,

Tian Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140771 - 140771

Published: Feb. 1, 2025

Language: Английский

Citations

1
Bisphenol A-Induced Cancer-Associated Adipocytes Promotes Breast Carcinogenesis Via CXCL12/AKT Signaling DOI

Zhiyuan Dong,

Liping He,

Jin‐Yi Wu

et al.

Molecular and Cellular Endocrinology, Journal Year: 2025, Volume and Issue: unknown, P. 112473 - 112473

Published: Jan. 1, 2025

Language: Английский

Citations

0
Industrial Kraft Lignin-Functionalized Cellulose Nanofluidic Membrane for Enhanced Osmotic Energy Conversion DOI

Ai‐Min Xu,

Shuang Qi,

Mehraj Ahmad

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0
Lignin-Based Nanoparticles for Combination of Tumor Oxidative Stress Amplification and Reactive Oxygen Species Responsive Drug Release DOI
Ziwei Zhou, Jin Wang, Xin Xu

et al.

Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: 35(8), P. 1207 - 1217

Published: July 11, 2024

In this study, maleic anhydride-modified lignin (LG-M), a ROS-cleavable thioketal (TK) bond, and polyethylene glycol (PEG) were used to synthesize lignin-based copolymer (LG-M(TK)-PEG). Doxorubicin (DOX) was attached the bond in LG-M(TK)-PEG for preparation of ROS-activatable DOX prodrug (LG-M(TK-DOX)-PEG). Nanoparticles (NPs) with size 125.7 ± 3.1 nm prepared by using LG-M(TK-DOX)-PEG, they exhibited enhanced uptake cancer cells compared free DOX. Notably, presence nanoparticles could boost ROS production breast 4T1 while showing little effect on L929 normal cells. This selective facilitated specific activation tumor microenvironment, resulting superior inhibitory effects biosafety relative work demonstrates potential LG-M(TK-DOX)-PEG NPs as an efficient drug delivery system treatment.

Language: Английский

Citations

2
Multi‐Solvent‐Induced Gradient Aggregation Rendered Superstrong, Tough, Stretchable, and Fatigue‐Resistant Lignin‐Based Supramolecular Hydrogels DOI Open Access
Yihui Gu, Wenjuan Wu, Chaofeng Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract A hydrogel that is expected as a biomedical load‐bearing material remains substantial challenge. In this work, multi‐solvent‐induced gradient aggregation state strategy developed to construct lignin‐based supramolecular hydrogels feature superstrong, tough, stretchable, and fatigue‐resistant properties. The multi‐solvent high‐temperature annealing induces the crystallization of polyvinyl alcohol self‐assembly lignin. interior strong hydrogen‐binding external weak non‐covalent‐binding forms microstructure compact macrostructure, where lignin acts an interfacial molecular bridge. By sharing interconnection points collaboratively dissipate energy, demonstrate high modulus (74.4 MPa), toughness (90 MJ m −3 ), tear (34,000 J −2 tensile (24.8 compressive strength (60 MPa). Moreover, such also exhibit extraordinary fatigue resistance, biocompatibility, reactive oxygen species scavenging activity. This non‐covalent conjoined‐network caused by provides new design potential for developing biomaterials mimic materials (e.g., natural tendons ligaments).

Language: Английский

Citations

2
Simple theranostics nanoagent for precision suppression of tumor growth and Metastasis: A traditional fermented product having a novel functional breakthrough DOI

Pengmin Liu,

Rong Dai,

Juan Li

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 156545 - 156545

Published: Oct. 10, 2024

Language: Английский

Citations

0
Versatile Carrier-Free Binary Nanodrugs Based on Metformin/Epigallocatechin Gallate Nanoparticles: Exploring Its Properties and Potential in Cancer Treatment† DOI

Huiyu Zou,

ErKang Bian,

Jinyun He

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Epigallocatechin gallate (EGCG), an important active component extracted from green tea, has attracted much attention due to its multiple biological activities such as antioxidant, antibacterial, anti-inflammatory, and antitumor effects.

Language: Английский

Citations

0