Journal of Polymer Science,
Journal Year:
2024,
Volume and Issue:
62(13), P. 3073 - 3091
Published: May 15, 2024
Abstract
Hydrogel‐based
materials
represent
promising
candidates
for
drug
delivery.
In
our
research,
we
synthesized
a
series
of
hydrogels—PVATU‐1
(2:1),
PVATU‐2
(1:1),
and
PVATU‐3
(0.5:1)—by
adjusting
the
poly(vinyl
alcohol)
(PVA)
ratio
while
maintaining
constant
allylthiourea
(ATU)
monomer
glutaraldehyde
cross‐linker,
aiming
to
understand
their
impacts
on
gelation.
These
PVATU
hydrogels
displayed
impressive
swelling
in
neutral
conditions
exhibited
visible
self‐healing
capabilities.
Notably,
PVATU‐1
shows
superior
mechanical
strength
among
variants.
Surface
analysis
using
AFM
SEM
unveiled
porous
structures
within
hydrogels,
thermal
stability
tests
indicated
resilience
up
200°C.
DSC
revealed
minimal
variation
glass
transition
temperatures
(
T
g
),
affirming
stability.
A
distinct
endothermic
peak
around
250–350°C
across
all
confirmed
semi‐crystalline
nature,
corroborated
by
powder
XRD.
Noteworthy,
demonstrated
optimal
loading
releasing
efficiency
levofloxacin,
with
74.5%
82.8%
18
h.
Biocompatibility
assessments
HeLa
cells
affirmed
nontoxicity
hydrogel
treatments.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(38)
Published: July 28, 2024
Abstract
Tuberculosis,
a
fatal
infectious
disease
caused
by
Mycobacterium
tuberculosis
(
M.tb
),
is
difficult
to
treat
with
antibiotics
due
drug
resistance
and
short
half‐life.
Phototherapy
represents
promising
alternative
in
combating
.
Exploring
an
intelligent
material
allowing
effective
treatment
definitely
appealing,
yet
significantly
challenging
task.
Herein,
all‐in‐one
biomimetic
therapeutic
nanoparticle
featured
aggregation‐induced
second
near‐infrared
emission,
granuloma‐targeting,
self‐oxygenation
constructed,
which
can
serve
for
prominent
fluorescence
imaging‐navigated
combined
phototherapy
toward
tuberculosis.
After
camouflaging
the
erythrocyte
membrane,
nanoparticles
show
prolonged
blood
circulation
increased
selective
accumulation
granuloma.
Upon
laser
irradiation,
loading
photosensitizer
of
emission
elevates
production
reactive
oxygen
species
(ROS),
causing
damage
death.
The
delivery
relieve
hypoxic
granuloma
microenvironment
supports
ROS
generation
during
photodynamic
therapy.
Meanwhile,
photothermal
agent,
Prussian
blue
nanoparticles,
plays
role
good
killing
effect
on
Moreover,
growth
proliferation
colonies
are
effectively
inhibited
nanoparticle‐treated
tuberculous
model
mice,
suggesting
effects
enhancing
therapy
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
A
biodegradable
and
biocompatible
micellar-based
drug
delivery
system
was
developed
using
amphiphilic
methoxy-poly(ethylene
glycol)-cholesterol
(C1)
poly(ethylene
glycol)-S-S-cholesterol
(C2)
conjugates
applied
to
the
tumoral
release
of
water-insoluble
curcumin.
These
synthesized
surfactants
C1
C2
were
found
form
stable
micelles
(CMC
∼
6
μM)
an
average
hydrodynamic
size
around
20-25
nm.
The
curcumin-encapsulated
micelle
formulated
by
a
solvent
evaporation
method.
very
high
encapsulation
efficiency
(EE)
∼88%
loading
(DL)
capacity
∼9%
determined
for
both
micelles.
From
reduced
rate
curcumin
degradation
differential
scanning
calorimetry
(DSC)
analysis,
stability
curcumin-loaded
be
higher
than
that
unloaded
micelle,
which
confirmed
more
compact
structural
arrangement
in
presence
hydrophobic
pH-sensitive
(faster
with
decrease
pH)
observed
attributed
diffusion
relaxation/erosion
micellar
aggregates.
To
achieve
reduction
environment-sensitive
release,
disulfide
(S-S)
chemical
linkage-incorporated
mPEG-cholesterol
conjugate
synthesized,
show
glutathione-responsive
faster
vitro
experiments
carried
out
SCC9
oral
cancer
cell
lines
showed
blank
noncytotoxic
at
lower
concentrations
(<50
μM),
while
inhibited
proliferation
promoted
apoptosis.
An
increased
cytotoxicity
compared
itself,
demonstrating
better
penetration
efficacy
micelle.
results
further
supplemented
vivo
anticancer
analysis
formulations
mice
xenograft
model.
Notably,
significantly
stronger
apoptotic
effect
micelles,
indicating
GSH
improved
bioavailability.
In
conclusion,
advantages
small
size,
efficiency,
loading,
simple
preparing
technique,
biocompatibility,
good
performance
may
have
potential
used
as
carrier
sustained
stimuli-responsive
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(26), P. 16450 - 16467
Published: June 19, 2024
Nanozymes,
which
can
selectively
scavenge
reactive
oxygen
species
(ROS),
have
recently
emerged
as
promising
candidates
for
treating
ischemic
stroke
and
traumatic
brain
injury
(TBI)
in
preclinical
models.
ROS
overproduction
during
the
early
phase
of
these
diseases
leads
to
oxidative
damage,
has
been
a
major
cause
mortality
worldwide.
However,
clinical
application
ROS-scavenging
enzymes
is
limited
by
their
short
vivo
half-life
inability
cross
blood-brain
barrier.
mimic
catalytic
function
natural
enzymes,
several
advantages,
including
cost-effectiveness,
high
stability,
easy
storage.
These
advantages
render
them
superior
disease
diagnosis
therapeutic
interventions.
This
review
highlights
recent
advancements
nanozyme
applications
TBI,
emphasizing
potential
mitigate
detrimental
effect
overproduction,
inflammation,
barrier
compromise.
Therefore,
nanozymes
represent
treatment
modality
conditions
future
medical
practices.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
ABSTRACT
Contagious
diseases
caused
by
different
types
of
highly
contagious
pathogens,
such
as
SARS‐CoV‐2,
monkeypox
virus,
Mycobacterium
tuberculosis
,
and
human
immunodeficiency
could
trigger
global
outbreaks
bring
a
huge
public
health
burden.
Advanced
diagnostic,
therapeutic,
preventive
strategies
are
urgently
needed
to
deal
with
the
epidemic
diseases.
Aggregation‐induced
emission
(AIE)
has
emerged
one
promising
candidates
that
exhibit
tunable
photophysical
properties,
high
biocompatibility,
exceptional
photostability,
distinguishing
aggregation‐enhanced
fluorescence.
As
result,
they
offer
effective
for
diagnosis,
treatment,
prevention
This
review
systematically
outlined
latest
research
progress
AIE‐based
biomaterials
mechanisms
in
The
versatility
AIE
molecules,
well
efficient
fluorescence
potential
innovative
combat
these
challenges.
Thanks
recent
advances
materials
science
better
understanding
aggregation‐induced
luminogens
(AIEgens),
AIEgens
have
great
provide
solutions
detection,
By
reviewing
state‐of‐the‐art
methods
killing,
agents
highlighting
technological
developments,
this
outlook
aims
promote
development
new
means
control
emerging,
re‐emerging,
major
further
activities
critical
area
research.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 7, 2025
Abstract
Remodeling
the
adaptive
microenvironment
with
biomaterials
presents
a
promising
avenue
for
addressing
chronic
inflammation
that
contributes
to
spinal
cord
injury
(SCI)
repair.
Hydrogels
have
been
widely
employed
enhance
tissue
regeneration
following
SCI.
Additionally,
zinc
(Zn)
ions
are
effective
in
immune
modulation
central
nervous
system.
However,
significant
challenges
remain
preparing
hydrogels
combining
bioactive
Zn
2+
biological
functionality
traumatic
SCI
In
this
study,
self‐healing
hydrogel
composed
of
an
alginate
network
based
on
dynamic
/bisphosphonate
(BP)
cross–linking,
and
silk
fibroin
interpenetrating
polymer
is
reported.
It
observed
neurite
outgrowth
promoted
by
shows
dependency
concentration.
Moreover,
‐releasing
enhances
neuronal
axon
growth
influences
neural
stem
cell
proliferation
differentiation.
addition,
regulates
microglial
fate
upregulating
anti‐inflammatory
signaling
molecule
A20
through
inhibition
NF‐κB
pathway.
Therefore,
effectively
improves
response
while
promoting
functional
recovery,
including
motor,
sensory,
bladder
function
completely
transected
These
results
indicate
/BP‐based
holds
potential
treatment.
