NIR‐II AIE Luminogen‐Based Erythrocyte‐Like Nanoparticles with Granuloma‐Targeting and Self‐Oxygenation Characteristics for Combined Phototherapy of Tuberculosis

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)

Published: July 28, 2024

Abstract Tuberculosis, a fatal infectious disease caused by Mycobacterium tuberculosis ( M.tb ), is difficult to treat with antibiotics due drug resistance and short half‐life. Phototherapy represents promising alternative in combating . Exploring an intelligent material allowing effective treatment definitely appealing, yet significantly challenging task. Herein, all‐in‐one biomimetic therapeutic nanoparticle featured aggregation‐induced second near‐infrared emission, granuloma‐targeting, self‐oxygenation constructed, which can serve for prominent fluorescence imaging‐navigated combined phototherapy toward tuberculosis. After camouflaging the erythrocyte membrane, nanoparticles show prolonged blood circulation increased selective accumulation granuloma. Upon laser irradiation, loading photosensitizer of emission elevates production reactive oxygen species (ROS), causing damage death. The delivery relieve hypoxic granuloma microenvironment supports ROS generation during photodynamic therapy. Meanwhile, photothermal agent, Prussian blue nanoparticles, plays role good killing effect on Moreover, growth proliferation colonies are effectively inhibited nanoparticle‐treated tuberculous model mice, suggesting effects enhancing therapy

Language: Английский

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Recent advances in MOF-based nanozymes: Synthesis, activities, and bioapplications

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 263, P. 116593 - 116593

Published: July 18, 2024

Language: Английский

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Amphiphilic Poly(ethylene glycol)-Cholesterol Conjugate: Stable Micellar Formulation for Efficient Loading and Effective Intracellular Delivery of Curcumin

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

A biodegradable and biocompatible micellar-based drug delivery system was developed using amphiphilic methoxy-poly(ethylene glycol)-cholesterol (C1) poly(ethylene glycol)-S-S-cholesterol (C2) conjugates applied to the tumoral release of water-insoluble curcumin. These synthesized surfactants C1 C2 were found form stable micelles (CMC ∼ 6 μM) an average hydrodynamic size around 20-25 nm. The curcumin-encapsulated micelle formulated by a solvent evaporation method. very high encapsulation efficiency (EE) ∼88% loading (DL) capacity ∼9% determined for both micelles. From reduced rate curcumin degradation differential scanning calorimetry (DSC) analysis, stability curcumin-loaded be higher than that unloaded micelle, which confirmed more compact structural arrangement in presence hydrophobic pH-sensitive (faster with decrease pH) observed attributed diffusion relaxation/erosion micellar aggregates. To achieve reduction environment-sensitive release, disulfide (S-S) chemical linkage-incorporated mPEG-cholesterol conjugate synthesized, show glutathione-responsive faster vitro experiments carried out SCC9 oral cancer cell lines showed blank noncytotoxic at lower concentrations (<50 μM), while inhibited proliferation promoted apoptosis. An increased cytotoxicity compared itself, demonstrating better penetration efficacy micelle. results further supplemented vivo anticancer analysis formulations mice xenograft model. Notably, significantly stronger apoptotic effect micelles, indicating GSH improved bioavailability. In conclusion, advantages small size, efficiency, loading, simple preparing technique, biocompatibility, good performance may have potential used as carrier sustained stimuli-responsive

Language: Английский

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Synergistic microglial modulation by laminarin-based platinum nanozymes for potential intracerebral hemorrhage therapy

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123212 - 123212

Published: Feb. 24, 2025

Language: Английский

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Zn-DHM nanozymes regulate metabolic and immune homeostasis for early diabetic wound therapy

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 63 - 84

Published: March 6, 2025

Language: Английский

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Review of recent advances in bone scaffold fabrication methods for tissue engineering for treating bone diseases and sport injuries

Tissue and Cell, Journal Year: 2024, Volume and Issue: 88, P. 102390 - 102390

Published: April 19, 2024

Language: Английский

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Nanozymes: Potential Therapies for Reactive Oxygen Species Overproduction and Inflammation in Ischemic Stroke and Traumatic Brain Injury

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16450 - 16467

Published: June 19, 2024

Nanozymes, which can selectively scavenge reactive oxygen species (ROS), have recently emerged as promising candidates for treating ischemic stroke and traumatic brain injury (TBI) in preclinical models. ROS overproduction during the early phase of these diseases leads to oxidative damage, has been a major cause mortality worldwide. However, clinical application ROS-scavenging enzymes is limited by their short vivo half-life inability cross blood-brain barrier. mimic catalytic function natural enzymes, several advantages, including cost-effectiveness, high stability, easy storage. These advantages render them superior disease diagnosis therapeutic interventions. This review highlights recent advancements nanozyme applications TBI, emphasizing potential mitigate detrimental effect overproduction, inflammation, barrier compromise. Therefore, nanozymes represent treatment modality conditions future medical practices.

Language: Английский

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Advancing Aggregation‐Induced Emission‐Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

ABSTRACT Contagious diseases caused by different types of highly contagious pathogens, such as SARS‐CoV‐2, monkeypox virus, Mycobacterium tuberculosis , and human immunodeficiency could trigger global outbreaks bring a huge public health burden. Advanced diagnostic, therapeutic, preventive strategies are urgently needed to deal with the epidemic diseases. Aggregation‐induced emission (AIE) has emerged one promising candidates that exhibit tunable photophysical properties, high biocompatibility, exceptional photostability, distinguishing aggregation‐enhanced fluorescence. As result, they offer effective for diagnosis, treatment, prevention This review systematically outlined latest research progress AIE‐based biomaterials mechanisms in The versatility AIE molecules, well efficient fluorescence potential innovative combat these challenges. Thanks recent advances materials science better understanding aggregation‐induced luminogens (AIEgens), AIEgens have great provide solutions detection, By reviewing state‐of‐the‐art methods killing, agents highlighting technological developments, this outlook aims promote development new means control emerging, re‐emerging, major further activities critical area research.

Language: Английский

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Robust advantage of MXene/g-C3N4 loaded on Fe2WO6/BiIO4 nano-platform for chemo-peroxidase colorimetric detection of uranyl ions, antifungal properties, photocatalytic degradation of p-chlorophenol, and eco-toxicity studies

Diamond and Related Materials, Journal Year: 2024, Volume and Issue: 145, P. 111129 - 111129

Published: April 23, 2024

Language: Английский

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Glucose‐Responsive Zn(II)‐Porphyrin COF Adhesive Hydrogels With Dual‐Active Sites and GOX‐Like Activity for Accelerated Wound Healing

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract Effective glycemic control is paramount for optimal wound healing in diabetic patients. Traditional antibacterial and anti‐inflammatory treatments, while important, often fall short addressing the hyperglycemic conditions of wounds. Therefore, development novel therapeutic strategies accelerating has garnered escalating attention. Covalent organic frameworks (COFs) are an emerging class crystalline porous polymers constructed through strong covalent bonds. Their exceptional structural tunability renders them as ideal platform advanced applications. Herein, two redox‐responsive Zn(II)‐coordinated porphyrin COF hydrogels constructed, which demonstrate rapid blood glucose reduction localized tissues, along with improved angiogenesis, reactive oxygen species (ROS) scavenging, photothermal antimicrobial capacities within environment patients, thereby effectively controlling infections concurrently promoting healing. Specifically, COFs built‐in dual active sites, i.e., disulfide or diselenide moieties, can be cleaved by ROS, releasing Zn(II) ions that possess tissue‐repairing properties. Furthermore, Zn(II)‐porphyrin exhibits oxidase (GOX)‐like activity, catalyzing conversion into non‐glucose metabolites. This synergistic combination glucose‐responsive release GOX‐like activities restores tissue redox balance improves microenvironment, offering a promising strategy diagnosis treatment

Language: Английский

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