Recent Advances in Biomimetic Nanodelivery Systems for the Treatment of Depression DOI Creative Commons
Ping Jiang,

Jian Li

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101781 - 101781

Published: April 17, 2025

Depression and cognitive disorders remain major challenges in healthcare, with conventional treatments often facing limitations such as slow onset, side effects, poor drug delivery to the brain. Biomimetic nanodelivery systems, including nanozymes, cell membrane-based exosomes, have emerged promising solutions these issues. These systems leverage natural biological processes enhance targeting, improve bioavailability, regulate complex pathways. Nanoenzymes, their catalytic properties, offer antioxidant anti-inflammatory benefits, while membranes exosomes provide efficient targeting immune evasion. However, remain, immaturity of large-scale production techniques, stability concerns, incomplete understanding mechanisms action. Moreover, long-term safety, pharmacokinetics, toxicity require further investigation. Despite obstacles, potential biomimetic revolutionize depression treatment is significant. Future research should focus on optimizing preparation, improving release, ensuring clinical safety. Multidisciplinary collaboration will be essential for advancing from laboratory practice, offering new therapeutic avenues other neurological disorders.

Language: Английский

Stepwise targeted strategies for improving neurological function by inhibiting oxidative stress levels and inflammation following ischemic stroke DOI
Yi Li, Jun Liao,

Liyan Xiong

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 607 - 622

Published: March 15, 2024

Language: Английский

Citations

34
Mitochondria in brain diseases: Bridging structural-mechanistic insights into precision-targeted therapies DOI Creative Commons
Jun Liao, Wenxiu He, Lisha Li

et al.

Published: Feb. 1, 2025

Language: Английский

Citations

2
Targeted nanozyme-enabled treatment of cardiovascular diseases DOI Creative Commons
Lin Liu,

Jie Lv,

Xiuxiu Wang

et al.

Acta Materia Medica, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 1, 2025

Cardiovascular diseases (CVDs) pose a significant threat to human health due the high mortality and morbidity rates. Traditional drugs often have limited efficacy inherent constraints, such as low bioavailability notable side effects. As highly regarded therapeutic strategy, nanotechnology offers new perspectives means for treating CVDs. Nanozyme-based targeted specifically address biological processes in areas affected by CVDs, thereby achieving precise treatment. Compared traditional drugs, nanozymes offer advantages, efficiency, specificity, controllability, fewer effects, showing great This paper first explores design strategies mechanisms of nanozyme-based therapy, then introduces its application key ischemic stroke, myocardial infarction, coronary heart disease. Finally, discusses challenges introducing into clinical applications future development prospects treatment

Language: Английский

Citations

1
Advanced Nano Delivery System for Stem Cell Therapy for Alzheimer's Disease DOI
Yilong Pan,

Long Li,

Ning Cao

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122852 - 122852

Published: Sept. 30, 2024

Language: Английский

Citations

8
Targeted pathophysiological treatment of ischemic stroke using nanoparticle-based drug delivery system DOI Creative Commons
Wei Liu, Lubin Liu, Hong Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 20, 2024

Ischemic stroke poses significant challenges in terms of mortality and disability rates globally. A key obstacle to the successful treatment ischemic lies limited efficacy administering therapeutic agents. Leveraging unique properties nanoparticles for brain targeting crossing blood-brain barrier, researchers have engineered diverse nanoparticle-based drug delivery systems improve outcomes stroke. This review provides a concise overview pathophysiological mechanisms implicated stroke, encompassing oxidative stress, glutamate excitotoxicity, neuroinflammation, cell death, elucidate potential targets systems. Furthermore, outlines classification according these distinct physiological processes. categorization aids identifying attributes commonalities that target specific pathways thereby facilitating advancement nanomedicine development. The discusses benefits existing associated with employing offering new perspectives on designing efficacious enhance outcomes.

Language: Английский

Citations

7
Developing targeted antioxidant nanomedicines for ischemic penumbra: Novel strategies in treating brain ischemia-reperfusion injury DOI Creative Commons
Zhitao Hou, Jacob S. Brenner

Redox Biology, Journal Year: 2024, Volume and Issue: 73, P. 103185 - 103185

Published: May 7, 2024

During cerebral ischemia-reperfusion conditions, the excessive reactive oxygen species in ischemic penumbra region, resulting neuronal oxidative stress, constitute main pathological mechanism behind damage. Swiftly reinstating blood perfusion zone and suppressing injury are key to effective treatment. Presently, antioxidants clinical use suffer from low bioavailability, a singular of action, substantial side effects, severely restricting their therapeutic impact widespread usage. Recently, nanomedicines, owing controllable size shape surface modifiability, have demonstrated good application potential biomedicine, potentially breaking through bottleneck developing neuroprotective drugs for strokes. This manuscript intends clarify mechanisms provides comprehensive review design synthesis antioxidant action applications reversing damage, thus presenting novel approaches stroke prevention

Language: Английский

Citations

6
Nano-enhanced nature medicine for ischemic stroke: Opportunities and challenges DOI Creative Commons

Jihao Yang,

Lingyi Guo, Jun Liao

et al.

Biomedical Technology, Journal Year: 2024, Volume and Issue: 7, P. 32 - 45

Published: July 16, 2024

Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through bioactive compounds, which target the multifaceted nature stroke-induced damage. However, clinical application NM is limited by challenges in bioavailability specificity. This review article presents an advanced perspective on integrating nanotechnology with create potent nanodelivery systems for ischemic treatment. We highlight pathological underpinnings stroke, including oxidative stress, inflammation, apoptosis, discuss how compounds offer targeted mitigation strategies. By incorporating platforms, such as liposomes nanoparticles, these -based can achieve enhanced targeting, solubility, controlled release, significantly improving outcomes while reducing side effects. Despite developments, translation nano-enhanced into practice faces obstacles, manufacturing scalability, regulatory approval, safety evaluations. emphasizes potential combining advance therapy, calling integrated research efforts overcome existing barriers fully realize benefits this approach.

Language: Английский

Citations

5
Neutrophil membrane-based biomimetic metal-polyphenol self-assembled nanozyme for the targeting treatment of early brain injury following subarachnoid hemorrhage DOI Creative Commons
Wei Huang,

Yu Tian,

Jing Ma

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155643 - 155643

Published: Sept. 1, 2024

Language: Английский

Citations

5
Intranasal liposomes co-delivery of Aβ-targeted KLVFF and ROS-responsive ceria for synergistic therapy of Alzheimer’s disease DOI Creative Commons

Qiujie Shan,

Yue Zhi,

Yi Chen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 153210 - 153210

Published: June 16, 2024

β-Amyloid (Aβ) aggregation and oxidative stress are primary pathological features of Alzheimer's disease (AD). Combination therapies that target brain tissue corporately address these main factors required for effective AD treatment. Here, we developed a multifunctional liposome delivery system (KLVFF@LIP-CeO2) co-delivery Aβ-targeted KLVFF reactive oxygen species (ROS)-responsive Ceria (CeO2) through intranasal administration. After Aβ1-42-induced ROS apoptosis in HT22 cells, KLVFF@LIP-CeO2 exhibited significant protective effects by inhibiting Aβ scavenging multi-ROS. With features, verified the therapeutic effectiveness APPswe/PSEN1dE9 (APP/PS1) model mice. administration, demonstrated sufficient rapid accumulation significantly alleviated deposition stress, contributing to rescue cognitive impairment APP/PS1 These results highlight clinical potential multi-targeted nanoparticles synergistic therapy AD.

Language: Английский

Citations

4
Substrate-Switched Dual-Signal Self-Powered Sensing System Based on Dual-Nanozyme Activity of Bimetal-Doped CeO2 Nanospheres for Electrochemical Assay of Aflatoxin B1 DOI
Zhuo Xing, Cui Wang,

Zeguo Fan

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(37), P. 14944 - 14952

Published: Aug. 29, 2024

The long-term operation feature of enzymatic biofuel cell-based self-powered biosensor (EBFC-SPB) endows them with the potential to execute dual-signal biosensing without having integrate an extra signal acquisition device. Herein, cobalt and manganese codoped CeO2 nanospheres (CoMn-CeO2 NSs) glucose-oxidase-like peroxidase-like activities have been developed as substrate-switched dual-channel transduction components in EBFC-SPB for a assay aflatoxin B1 (AFB1). CoMn-CeO2 NSs modified aptamer are anchored complementary DNA-attached bioanode by base pairing, which catalyze glucose oxidation together oxidase (GOx) on bioanode. Once AFB1 appears, will be released from due binding specificity aptamer, resulting decreased catalytic efficiency first declining stage EBFC-SPB. Accompanied introduction H2O2, residual switch activity mediate production benzo-4-chlorohexadienone (4-CD) precipitate, increases steric hindrance yields another By assessing variation amplitudes during these two stages, has realized satisfying results. This work not only breaks ground bioassays but also deepens application nanozymes

Language: Английский

Citations

4