The blood–brain barriers: novel nanocarriers for central nervous system diseases
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 26, 2025
Abstract
The
central
nervous
system
(CNS)
diseases
are
major
contributors
to
death
and
disability
worldwide.
However,
the
blood–brain
barrier
(BBB)
often
prevents
drugs
intended
for
CNS
from
effectively
crossing
into
brain
parenchyma
deliver
their
therapeutic
effects.
is
a
semi-permeable
with
high
selectivity.
BBB
primarily
manages
transport
of
substances
between
blood
CNS.
To
enhance
drug
delivery
disease
treatment,
various
brain-based
strategies
overcoming
have
been
developed.
Among
them,
nanoparticles
(NPs)
emphasized
due
multiple
excellent
properties.
This
review
starts
an
overview
BBB’s
anatomical
structure
physiological
roles,
then
explores
mechanisms,
both
endogenous
exogenous,
that
facilitate
NP
passage
across
BBB.
text
also
delves
how
nanoparticles'
shape,
charge,
size,
surface
ligands
affect
ability
cross
offers
different
nanoparticle
classifications.
concludes
examination
current
challenges
in
utilizing
nanomaterials
discusses
corresponding
directions
solutions.
aims
propose
innovative
diagnostic
approaches
design
more
effective
Graphical
abstract
Language: Английский
Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(1), P. 8 - 8
Published: Jan. 1, 2025
Each
year,
the
number
of
cases
strokes
and
deaths
due
to
this
is
increasing
around
world.
This
could
be
work
stress,
lifestyles,
unhealthy
food
habits,
several
other
reasons.
Currently,
there
are
traditional
methods
like
thrombolysis
mechanical
thrombectomy
for
managing
strokes.
The
current
approach
has
limitations,
delayed
diagnosis,
limited
therapeutic
delivery,
risks
secondary
injuries.
So,
a
need
some
effective
reliable
management
strokes,
which
help
in
early
diagnosis
followed
by
treatment
Nanotechnology
played
an
immense
role
recently,
it
emerged
as
transformative
solution
offering
innovative
diagnostic
tools
strategies.
Nanoparticles
(NPs)
belonging
classes,
including
metallic
(metallic
metal
oxide),
organic
(lipids,
liposome),
carbon,
can
cross
blood–brain
barrier
may
exhibit
potential
various
Moreover,
these
NPs
have
exhibited
promise
improving
imaging
specificity
delivery
precise
drug
real-time
monitoring
efficacy.
Nanomaterials
cerium
oxide
(CeO2)
liposome-encapsulated
agents
neuroprotective
properties
that
reduce
oxidative
stress
promote
neuroregeneration.
In
present
article,
authors
emphasized
significant
advancements
nanomedicine
stroke,
NPs-based
systems,
neuroregenerative
therapies,
multimodal
advancements.
Language: Английский
Unravelling neuroregenerative and neuroprotective roles of Wnt/β-catenin pathway in ischemic stroke: Insights into molecular mechanisms
Srikanth Yadava,
No information about this author
Dontiboina Harikrishna Reddy,
No information about this author
Venkata Prasuja Nakka
No information about this author
et al.
Neuroscience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Language: Английский
Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 14, 2024
RNA
therapeutics,
such
as
mRNA,
siRNA,
and
CRISPR–Cas9,
present
exciting
avenues
for
treating
diverse
diseases.
However,
their
potential
is
commonly
hindered
by
vulnerability
to
degradation
poor
cellular
uptake,
requiring
effective
delivery
systems.
Lipid
nanoparticles
(LNPs)
have
emerged
a
leading
choice
in
vivo
delivery,
offering
protection
against
degradation,
enhanced
facilitation
of
endosomal
escape.
LNPs
encounter
numerous
challenges
targeted
vivo,
demanding
advanced
particle
engineering,
surface
functionalization
with
targeting
ligands,
profound
comprehension
the
biological
milieu
which
they
function.
This
review
explores
structural
physicochemical
characteristics
LNPs,
in-vivo
fate,
customization
therapeutics.
We
highlight
quality-by-design
(QbD)
approach
beyond
liver,
focusing
on
biodistribution,
immunogenicity,
toxicity.
In
addition,
we
explored
current
strategies
associated
ensuring
repeated-dose
efficacy,
safety,
tissue-specific
gene
delivery.
Furthermore,
provide
insights
into
clinical
applications
various
classes
diseases
finally
prospects
Language: Английский
Brain-Targeted Reactive Oxygen Species in Hypertension: Unveiling Subcellular Dynamics, Immune Cross-Talk, and Novel Therapeutic Pathways
Renjun Wang,
No information about this author
Min Wang,
No information about this author
Dongshu Du
No information about this author
et al.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 408 - 408
Published: March 28, 2025
Hypertension
(HTN)
is
a
complex
disease
with
significant
global
health
implications,
driven
by
neural
and
oxidative
mechanisms.
Reactive
oxygen
species
(ROS),
once
considered
mere
metabolic
byproducts,
are
now
recognized
as
one
of
the
key
contributors
to
dysfunction
autonomic
nerve
system,
which
involves
onset
progression
HTN.
This
review
highlights
dynamic
roles
ROS
in
neuronal
signaling,
subcellular
compartmentalization,
brain–immune
interactions,
focusing
on
their
impacts
synaptic
remodeling,
neuroinflammation,
epigenetic
modifications
within
regions
such
paraventricular
nucleus
rostral
ventrolateral
medulla.
We
discuss
novel
sources,
including
microglia-derived
endoplasmic
reticulum
stress-related
ROS,
contributions
Subcellular
dynamics,
signaling
at
mitochondria-associated
membranes
microdomains,
explored
activators
sympathetic
system.
Emerging
evidence
has
linked
regulation,
histone
non-coding
RNA
expression,
sex-specific
differences
offering
insights
for
development
personalized
therapies.
Innovative
therapeutic
strategies
targeting
involve
precision
delivery
systems,
modulators,
circadian-optimized
antioxidants.
propose
several
priorities
future
research,
real-time
imaging
brain
translating
preclinical
findings
into
clinical
applications,
leveraging
medicine
develop
tailored
interventions
based
activity
genetic
predisposition.
Through
emphasizing
spatial
temporal
complexity
HTN,
this
identifies
opportunities
establishes
foundation
targeted
treatments
address
challenge.
Language: Английский
Multifunctional Light Emitters for Theranostics
Engineering materials,
Journal Year:
2025,
Volume and Issue:
unknown, P. 297 - 329
Published: Jan. 1, 2025
Language: Английский
Navigating Therapeutic Opportunities and Challenges with Micro/Nanomotors in Translational Medicine: A Review
Qingwei Zhou,
No information about this author
Yu Kong,
No information about this author
Xinyi Zhou
No information about this author
et al.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(20), P. 23321 - 23336
Published: Oct. 12, 2024
With
the
improvement
of
micromanufacturing
technology
and
further
elucidation
propulsion
mechanism,
manufacture
application
micro/nanomotors
have
made
great
progress.
However,
in
translational
medicine
is
still
its
infancy,
promise
research
remains
to
be
fully
realized.
In
this
paper,
preparation
status
their
prospects
were
reviewed.
The
representative
clinical
value
introduced.
addition,
paper
also
analyzes
possible
reasons
for
low
conversion
rate
proposes
current
challenges
future
indicate
a
direction
medicine.
Language: Английский
Extracellular Vesicles-in-Hydrogel (EViH) targeting pathophysiology for tissue repair
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
44, P. 283 - 318
Published: Oct. 23, 2024
Language: Английский
Review the role of oxygen-delivering nanobubbles in stroke therapy: A novel approach
F1000Research,
Journal Year:
2025,
Volume and Issue:
14, P. 406 - 406
Published: April 7, 2025
Abstract*
Stroke
remains
a
leading
cause
of
mortality
and
long-term
disability
worldwide,
necessitating
innovative
therapeutic
strategies.
The
advent
nanotechnology,
particularly
oxygen-delivering
nanobubbles
(ODNBs),
has
introduced
promising
avenue
for
enhancing
stroke
therapy.
ODNBs
have
demonstrated
the
ability
to
improve
oxygen
delivery,
enhance
efficacy,
provide
diagnostic
advantages
through
imaging
contrast
enhancement.
However,
challenges
such
as
toxicity,
off-target
effects,
regulatory
hurdles
must
be
addressed
before
clinical
translation.
This
review
synthesizes
latest
findings
on
in
therapy,
highlights
their
key
benefits
challenges,
explores
future
applications,
including
gene
therapy
brain
tissue
regeneration.
By
addressing
these
aspects,
this
aims
comprehensive
understanding
potential
revolutionizing
treatment.
Language: Английский
A Review of the Neuroprotective Properties of Exosomes Derived from Stem Cells and Exosome-Coated Nanoparticles for Treating Neurodegenerative Diseases and Stroke
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3915 - 3915
Published: April 21, 2025
Neurological
diseases,
including
neurodegenerative
disorders
and
stroke,
represent
significant
medical
challenges
due
to
their
complexity
the
limitations
of
current
treatment
approaches.
This
review
explores
potential
stem
cell
(SC)-derived
exosomes
(Exos)
as
a
transformative
therapeutic
strategy
for
these
diseases.
Exos,
especially
those
derived
from
SCs,
exhibit
natural
targeting
ability,
biocompatibility,
capacity
cross
blood-brain
barrier
(BBB),
making
them
ideal
vehicles
drug
delivery.
provides
an
in-depth
discussion
properties
advantages
SC-Exos.
It
highlights
synergistic
benefits
in
approaches
treat
neurological
article
discusses
mechanisms
action
SC-Exos,
highlighting
ability
target
specific
cells,
modulate
disease
pathways,
provide
controlled
release
agents.
Applications
have
been
investigated,
demonstrating
improve
outcomes
conditions
such
Alzheimer's
Disease
(AD),
Parkinson's
(PD),
stroke.
Moreover,
Exos-coated
nanoparticles
(NPs)
combine
Exos
with
multifunctionality
NPs.
integration
takes
advantage
exosome
membrane
biocompatibility
capabilities
while
preserving
NPs'
beneficial
features,
loading
release.
As
result,
NPs
may
enhance
precision,
efficacy,
safety
interventions.
In
conclusion,
SC-Exos
promising
innovative
approach
treating
Language: Английский