Phthalocyanine-Porphyrin Uniform Orthogonal Conjugated Oligomer for NIR Photothermal-Photodynamic Synergistic Antibacterial Treatment DOI Creative Commons
Wei Liu,

Wanru Zhao,

Gaoqiang Ma

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Abstract With the increase of antibiotic resistance worldwide, there is an urgent demand to develop new antibacterial agent and approaches address threat human health posed by ineffectiveness traditional antibiotics. In this work, orthogonal conjugated uniform oligomer bactericide SiPc-ddCPP was constructed between silicon phthalocyanine porphyrin via amide bond, which can effectively treat infection through photodynamic-photothermal combined therapy without considering drug resistance. Compared with organic photothermal agents induced unstable H-aggregation blue-shifted absorption fluorescence/ROS quenching, orthogonal-structured nanoparticle shows remarkably stability NIR effect (η = 31.15%) along fluorescence ROS generation, due photoinduced intramolecular energy transfer within SiPc-ddCPP. Antibacterial studies have shown that both Gram-positive Gram-negative bacteria could be efficiently annihilated in a few minutes synergistic PDT-PTT satisfactory bacterial targeting. These results suggest multifunctional bactericide, afford approach targeted anti-inflammation conquer crisis

Language: Английский

Carbon Dots with Integrated Photothermal Antibacterial and Heat‐Enhanced Antioxidant Properties for Diabetic Wound Healing DOI

Henggang Wang,

Shan Sun,

Ye Zhao

et al.

Small, Journal Year: 2024, Volume and Issue: 20(45)

Published: July 25, 2024

Abstract Diabetic wounds pose a persistent challenge due to their slow healing nature, primarily caused by bacterial infection and excessive reactive oxygen species (ROS)‐induced inflammation. In this study, carbon dots with synergistic antibacterial antioxidant properties, referred as AA‐CDs, are developed specifically for diabetic wound using straightforward solvothermal method. By utilizing cost‐effective precursors like citric acid ascorbic acid, AA‐CDs engineered possess tailored functions of photothermal sterilization ROS scavenging. The resulting demonstrats broad‐spectrum activity, particularly against multidrug‐resistant strains, along efficient scavenging both in solution within cells. Additionally, exhibits protective effect oxidative stress‐induced damage. Notably, high conversion efficiency (41.18%), displays heat‐enhanced performance, providing not only augmented but also additional protection stress, yielding true “1 + 1 > 2” effect. To facilitate use vivo, incorporated into thermally responsive hydrogel, which evident anti‐inflammatory properties modulating inflammatory factors significantly promots the wounds. This study underscores value integrated platforms highlights potential versatile CDs promising therapeutic agents biomedical applications.

Language: Английский

Citations

14
Combating Antibiotic-Resistant Bacterial Infection Using Coassembled Dimeric Antimicrobial Peptide-Based Nanofibers DOI

Guoyu Li,

Haoran Deng, Wanying Xu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The emergence of multidrug-resistant (MDR) pathogens, coupled with the limited effectiveness existing antibiotics in eradicating biofilms, presents a significant threat to global health care. This critical situation underscores urgent need for discovery and development antimicrobial agents. Recently, peptide-derived nanomaterials have shown promise combating such infections. Amino acid noncovalent forces, notably π–π stacking electrostatic interactions, remain underutilized guiding coassembly peptides into bacteriostatic nanomaterials. Thus, we constructed dimeric nanopeptide system using disulfide bonds cysteine. self-assembly nanofibers was realized by interaction aromatic amino acids (Trp, Phe, Pyr) attraction between oppositely charged (Asp Arg). optimal peptide 2D2W exhibits potent antibacterial activity against resistant bacteria is nontoxic. Mechanistically, penetrated outer membrane after adsorption, resulting plasma depolarization, homeostatic disruption, ultimately bacterial death. In mouse model peritonitis, demonstrated efficacy vivo treatment conclusion, design nanopeptides co-driven intermolecular forces provides promising avenue high-performance These advances may also facilitate application advancement peptide-based agents clinical practice.

Language: Английский

Citations

1
Near-infrared light-triggered in situ self-assembly nanomedicine for treating antibiotic-resistant bacterial infection DOI
Yu Zhang,

Chunhua Ren,

Huayang Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161303 - 161303

Published: March 1, 2025

Language: Английский

Citations

0
Orthogonally conjugated phthalocyanine-porphyrin oligomer for NIR photothermal-photodynamic antibacterial treatment DOI Creative Commons

Guixue Lian,

Wanru Zhao,

Gaoqiang Ma

et al.

Communications Chemistry, Journal Year: 2025, Volume and Issue: 8(1)

Published: March 14, 2025

Abstract With the increase of antibiotic resistance worldwide, there is an urgent demand to develop new fungicides and approaches address threat human health posed by ineffectiveness traditional antibiotics. In this work, orthogonal conjugated uniform oligomer bactericide SiPc-ddCPP was constructed between silicon phthalocyanine porphyrin, which can effectively treat infection through photodynamic-photothermal combined therapy without considering drug resistance. Compared with organic photothermal agents induced unstable H -aggregation blue-shifted absorption fluorescence/ROS quenching, orthogonal-structured nanoparticle shows remarkably stability NIR effect (η = 31.15%) along fluorescence ROS generation. Antibacterial studies have shown that both Gram-positive Gram-negative bacteria could be efficiently annihilated in a few minutes synergistic PDT-PTT satisfactory bacterial targeting. These results suggest multifunctional bactericide, afford approach sterilization conquer crisis

Language: Английский

Citations

0
Mitigating Antimicrobial Resistance through Strategic Design of Multimodal Antibacterial Agents Based on 1,2,3-Triazole with Click Chemistry DOI Creative Commons

Shabin N. Chathangad,

Vishnu N. Vijayan, Johnson George

et al.

ACS Bio & Med Chem Au, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

Language: Английский

Citations

0
Phyto-mediated synthesis ZnO/attapulgite nanocomposites using C.limon peel extract for enhancing the resistance against multidrug-resistant bacteria and fungi DOI
Yalong Li, Fangfang Yang,

Yinfeng Yang

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 170, P. 113470 - 113470

Published: Nov. 6, 2024

Language: Английский

Citations

1
Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection DOI Creative Commons

Xuanxuan Ma,

Na Yang, Ruoyu Mao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 30, 2024

The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited clinical application. Here, self-assembled AMPs composed multiple modules based on the principle associating natural marine peptide N6 with ß-sheet-forming were designed. It is noteworthy that one designed peptides, FFN could self-assemble into nanoparticles at 35.46 µM achieve dynamic transformation from nanofibers in presence bacteria, resulting increase stability trypsin tissues by 1.72-57.5 times compared N6. Additionally, exhibits broad spectrum antibacterial activity against multidrug-resistant (MDR) gram-positive (G

Language: Английский

Citations

1
Ga2Se3 nanosheets: Broad-spectrum antibacterial and antioxidant agents with low drug resistance DOI

Henggang Wang,

Shan Sun, Yang Jin

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 169, P. 113145 - 113145

Published: Sept. 13, 2024

Language: Английский

Citations

0
Phthalocyanine-Porphyrin Uniform Orthogonal Conjugated Oligomer for NIR Photothermal-Photodynamic Synergistic Antibacterial Treatment DOI Creative Commons
Wei Liu,

Wanru Zhao,

Gaoqiang Ma

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Abstract With the increase of antibiotic resistance worldwide, there is an urgent demand to develop new antibacterial agent and approaches address threat human health posed by ineffectiveness traditional antibiotics. In this work, orthogonal conjugated uniform oligomer bactericide SiPc-ddCPP was constructed between silicon phthalocyanine porphyrin via amide bond, which can effectively treat infection through photodynamic-photothermal combined therapy without considering drug resistance. Compared with organic photothermal agents induced unstable H-aggregation blue-shifted absorption fluorescence/ROS quenching, orthogonal-structured nanoparticle shows remarkably stability NIR effect (η = 31.15%) along fluorescence ROS generation, due photoinduced intramolecular energy transfer within SiPc-ddCPP. Antibacterial studies have shown that both Gram-positive Gram-negative bacteria could be efficiently annihilated in a few minutes synergistic PDT-PTT satisfactory bacterial targeting. These results suggest multifunctional bactericide, afford approach targeted anti-inflammation conquer crisis

Language: Английский

Citations

0