Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(17), P. 1444 - 1444
Published: Sept. 4, 2024
Sn-based
halide
perovskites
are
expected
to
be
the
best
replacement
for
toxic
lead-based
counterparts,
owing
their
similar
ionic
radii
and
optimal
band
gap
use
in
solar
cells,
as
well
versatile
light-emitting
diodes
photodetection
applications.
Concerns,
however,
exist
about
stability
under
ambient
conditions,
an
issue
that
is
exacerbated
polycrystalline
films
because
grain
boundaries
present
large
concentrations
of
defects
act
entrance
points
oxygen
water,
causing
Sn
oxidation.
A
current
thriving
research
area
perovskite
materials
fabrication
single
crystals,
promising
improved
optoelectronic
properties
due
excellent
uniformity,
reduced
defects,
absence
boundaries.
This
review
summarizes
most
recent
advances
crystal
perovskites,
with
emphasis
on
synthesis
methods,
compositional
engineering,
formation
mechanisms,
followed
by
a
discussion
various
challenges
appropriate
strategies
improving
performance
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(26)
Published: April 7, 2024
Abstract
Brain
disorders
represent
a
significant
challenge
in
medical
science
due
to
the
formidable
blood–brain
barrier
(BBB),
which
severely
limits
penetration
of
conventional
therapeutics,
hindering
effective
treatment
strategies.
This
review
delves
into
innovative
realm
biomimetic
nanodelivery
systems,
including
stem
cell‐derived
nanoghosts,
tumor
cell
membrane‐coated
nanoparticles,
and
erythrocyte
membrane‐based
carriers,
highlighting
their
potential
circumvent
BBB's
restrictions.
By
mimicking
native
properties,
these
nanocarriers
emerge
as
promising
solution
for
enhancing
drug
delivery
brain,
offering
strategic
advantage
overcoming
barrier's
selective
permeability.
The
unique
benefits
leveraging
membranes
from
various
sources
is
evaluated
advanced
technologies
fabricating
membrane‐encapsulated
nanoparticles
capable
masquerading
endogenous
cells
are
examined.
enables
targeted
broad
spectrum
therapeutic
agents,
ranging
small
molecule
drugs
proteins,
thereby
providing
an
approach
neurocare.
Further,
contrasts
capabilities
limitations
with
traditional
methods,
underlining
enable
targeted,
sustained,
minimally
invasive
modalities.
concluded
perspective
on
clinical
translation
underscoring
transformative
impact
landscape
intractable
brain
diseases.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Abstract
Glioblastoma
multiforme
(GBM)
is
a
highly
aggressive
and
malignant
brain
tumor
originating
from
glial
cells,
characterized
by
high
recurrence
rates
poor
patient
prognosis.
The
heterogeneity
complex
biology
of
GBM,
coupled
with
the
protective
nature
blood–brain
barrier
(BBB),
significantly
limit
efficacy
traditional
therapies.
rapid
development
nanoenzyme
technology
presents
promising
therapeutic
paradigm
for
rational
targeted
treatment
GBM.
In
this
review,
underlying
mechanisms
GBM
pathogenesis
are
comprehensively
discussed,
emphasizing
impact
BBB
on
strategies.
Recent
advances
in
nanoenzyme‐based
approaches
therapy
explored,
highlighting
how
these
nanoenzymes
enhance
various
modalities
through
their
multifunctional
capabilities
potential
precise
drug
delivery.
Finally,
challenges
prospects
translating
laboratory
research
to
clinical
application,
including
issues
stability,
targeting
efficiency,
safety,
regulatory
hurdles
critically
analyzed.
By
providing
thorough
understanding
both
opportunities
obstacles
associated
therapies,
future
directions
aimed
be
informed
contribute
more
effective
treatments
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Abstract
Nanomedicine
based
brain
targeting
strategies
have
emerged
as
a
promising
avenue
for
ischemic
stroke
(IS)
treatment.
However,
conventional
approaches
face
significant
challenges
in
manipulating
biodistribution
and
achieving
efficient
to
attain
adequate
therapeutic
effects.
Here,
this
limitation
is
overcame
by
developing
magnetic
field
driven,
mitochondria‐targeted
ceria
nanosystem
(MMTCe)
nanosystem.
By
anchoring
nanoparticles
the
cell
membrane,
targeted
delivery
of
achieved
through
use
an
external
field,
which
turn
targets
damaged
mitochondria
repairs
microenvironment.
MMTCe
exhibits
superior
accumulation
within
vitro
blood
barrier
(BBB)
model
rat
stroke.
This
mediates
mitochondrial
function,
thereby
inhibiting
oxidative
stress
aberrant
activation
microglial
cells,
ultimately
inducing
rebalancing
Complemented
favorable
biosafety
profile,
top‐down
fabrication
provides
general
strategy
diseases
informs
development
magnetically
driven
systems.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(15), P. 3805 - 3825
Published: Jan. 1, 2024
Stimuli-responsive
polymer-based
nanosystems
have
gained
significant
attention
for
cardiovascular
disease
theranostics.
This
review
summarizes
various
stimuli-responsive
used
diagnosing
and
treating
diseases.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 7, 2024
Abstract
Overproduction
of
reactive
oxygen
species
(ROS)
during
reperfusion
in
ischemic
stroke
(IS)
severely
impedes
neuronal
survival
and
results
high
rates
morbidity
disability.
The
effective
blood‐brain
barrier
(BBB)
penetration
brain
delivery
antioxidative
agents
remain
the
biggest
challenge
treating
reperfusion‐induced
cerebrovascular
neural
injury.
In
this
study,
a
metal‐organic
framework
(MOF)
nanozyme
(MIL‐101‐NH
2
(Fe/Cu))
with
ROS
scavenging
activities
to
encapsulate
neuroprotective
agent
rapamycin
is
fabricated
decorating
exterior
BBB‐targeting
protein
ligands
(transferrin),
thereby
realizing
enhanced
drug
retention
controlled
release
within
lesions
for
synergistic
treatment
IS.
Through
receptor‐mediated
transcellular
pathway,
transferrin‐coated
MOF
nanoparticles
achieved
efficient
transport
across
BBB
targeted
accumulation
at
cerebral
injury
site
mice
middle
artery
occlusion/reperfusion
(MCAO/R),
wherein
nanocarrier
exhibited
catalytic
decomposition
into
O
H
‐responsive
release.
By
its
BBB‐targeting,
antioxidative,
anti‐inflammatory,
antiapoptotic
properties,
nanosystem
addressed
multiple
pathological
factors
IS
realized
remarkable
effects,
leading
substantial
reduction
infarction
volume
accelerated
recovery
nerve
functions
MCAO/R
mouse
model.
This
MOF‐based
nanomedicine
provides
valuable
design
principles
therapy
multi‐mechanism
synergies.
Dion-Jacobson
(DJ)
phase
halide
perovskites
have
garnered
significant
attention
for
their
excellent
chemical
stability,
and
charge
transfer
properties.
As
the
ligand
asymmetry
increases,
band
gap
increases
(PDA-DMPD-N-MPDA).
The
partial
density
of
states
indicates
that
contribution
is
related
[PbI6]4-
octahedrons.
distribution
excitons
closely
linked
to
near
CBM
VBM.
excitonic
properties
reveal
maximum
exciton
binding
energies
(PDAPbI4-DMPDPbI4-N-MPDAPbI4,
0.048-0.259-0.273
eV),
which
are
consistent
with
changes
in
organic
chain
length.
absorption
spectra
shows
asymmetric
ligands
exhibit
better
light
visible
region.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
Abstract
Theranostic
applications
in
atherosclerosis
plaque
microenvironment‐triggered
nanoplatforms
are
significantly
compromised
by
the
complex
synthesis
procedure,
non‐specific
distribution,
and
limited
therapeutic
function.
Therefore,
development
of
a
facile
feasible
method
to
construct
pathology‐based
stimuli‐responsive
nanoplatform
with
satisfactory
theranostic
performance
remains
demanding
highly
anticipated
goal.
Herein,
novel
class
multifunctional
supra‐carbon
dots
(CDs),
denoted
as
MM@Ce‐CDs
NPs,
simple
nanoassembly
subsequent
coating
macrophage
membrane
(MM),
is
developed
for
targeted
reactive
oxygen
species‐trigged
positive
regulation
pathological
microenvironment
AS.
The
harvested
NPs
exhibit
activatable
fluorescence
properties,
photoacoustic
characteristics,
cascade
enzyme
performances,
which
can
be
effectively
activated
under
ROS
stimulation
microenvironment,
enabling
precise
control
over
functions,
while
markedly
enhancing
diagnostic
accuracy
efficacy
AS
management.
Besides,
manipulate
reducing
levels
inflammation,
alleviating
M1
infiltration,
inhibiting
foam
cell
formation,
all
together
suppressing
through
synergistic
mechanisms.
In
addition,
inherit
biomimetic
biological
functions
from
MM,
facilitating
specific
target
delivery