Single Crystal Sn-Based Halide Perovskites DOI Creative Commons
Aditya Bhardwaj, Daniela Marongiu, Valeria Demontis

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(17), P. 1444 - 1444

Published: Sept. 4, 2024

Sn-based halide perovskites are expected to be the best replacement for toxic lead-based counterparts, owing their similar ionic radii and optimal band gap use in solar cells, as well versatile light-emitting diodes photodetection applications. Concerns, however, exist about stability under ambient conditions, an issue that is exacerbated polycrystalline films because grain boundaries present large concentrations of defects act entrance points oxygen water, causing Sn oxidation. A current thriving research area perovskite materials fabrication single crystals, promising improved optoelectronic properties due excellent uniformity, reduced defects, absence boundaries. This review summarizes most recent advances crystal perovskites, with emphasis on synthesis methods, compositional engineering, formation mechanisms, followed by a discussion various challenges appropriate strategies improving performance

Language: Английский

Revolutionizing Neurocare: Biomimetic Nanodelivery Via Cell Membranes DOI
Jun Liao, Lidong Gong,

Qingqiang Xu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: April 7, 2024

Abstract Brain disorders represent a significant challenge in medical science due to the formidable blood–brain barrier (BBB), which severely limits penetration of conventional therapeutics, hindering effective treatment strategies. This review delves into innovative realm biomimetic nanodelivery systems, including stem cell‐derived nanoghosts, tumor cell membrane‐coated nanoparticles, and erythrocyte membrane‐based carriers, highlighting their potential circumvent BBB's restrictions. By mimicking native properties, these nanocarriers emerge as promising solution for enhancing drug delivery brain, offering strategic advantage overcoming barrier's selective permeability. The unique benefits leveraging membranes from various sources is evaluated advanced technologies fabricating membrane‐encapsulated nanoparticles capable masquerading endogenous cells are examined. enables targeted broad spectrum therapeutic agents, ranging small molecule drugs proteins, thereby providing an approach neurocare. Further, contrasts capabilities limitations with traditional methods, underlining enable targeted, sustained, minimally invasive modalities. concluded perspective on clinical translation underscoring transformative impact landscape intractable brain diseases.

Language: Английский

Citations

33
Recent Advances in Nanoenzymes Based Therapies for Glioblastoma: Overcoming Barriers and Enhancing Targeted Treatment DOI Creative Commons
Liyin Wang, Min Gu, Xiaoli Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor originating from glial cells, characterized by high recurrence rates poor patient prognosis. The heterogeneity complex biology of GBM, coupled with the protective nature blood–brain barrier (BBB), significantly limit efficacy traditional therapies. rapid development nanoenzyme technology presents promising therapeutic paradigm for rational targeted treatment GBM. In this review, underlying mechanisms GBM pathogenesis are comprehensively discussed, emphasizing impact BBB on strategies. Recent advances in nanoenzyme‐based approaches therapy explored, highlighting how these nanoenzymes enhance various modalities through their multifunctional capabilities potential precise drug delivery. Finally, challenges prospects translating laboratory research to clinical application, including issues stability, targeting efficiency, safety, regulatory hurdles critically analyzed. By providing thorough understanding both opportunities obstacles associated therapies, future directions aimed be informed contribute more effective treatments

Language: Английский

Citations

5
Myocardia‐Injected Synergistically Anti‐Apoptotic and Anti‐Inflammatory Poly(amino acid) Hydrogel Relieves Ischemia‐Reperfusion Injury DOI Open Access
Qiang Luo, Zhengming Li, Wei Sun

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Reperfusion therapy is the most effective treatment for acute myocardial infarction, but its efficacy frequently limited by ischemia‐reperfusion injury (IRI). While antioxidant and anti‐inflammatory therapies have shown significant potential in alleviating IRI, these strategies not yielded satisfactory clinical outcomes. For that, a thermo‐sensitive myocardial‐injectable poly(amino acid) hydrogel of methoxy poly(ethylene glycol) 45 ‐poly(L‐methionine 20 ‐ co ‐L‐alanine 10 ) (mPEG ‐P(Met ‐Ala ), PMA) loaded with FTY720 (PMA/FTY720) developed to address IRI through synergistic anti‐apoptotic effects. Upon injection into ischemic myocardium, PMA aqueous solution undergoes sol‐to‐gel phase transition gradually degrades response reactive oxygen species (ROS), releasing on demand. acts synergistically inhibit cardiomyocyte apoptosis modulate pro‐inflammatory M1 macrophage polarization toward M2 macrophages clearing ROS, thereby mitigating inflammatory promoting vascular regeneration. In rat model, PMA/FTY720 reduces apoptotic cell ratio 81.8%, increases density 34.0%, enhances left ventricular ejection fraction (LVEF) 12.8%. rabbit gel‐based sustained release enhanced LVEF an additional 7.2% compared individual treatment. summary, engineered effectively alleviates anti‐apoptosis anti‐inflammation actions, offering valuable treating IRI.

Language: Английский

Citations

3
Magnetic Field Driven Ceria Nanosystems for Mitochondria Targeted Therapy of Ischemic Stroke DOI Open Access
Jun Liao, Wenxiu He, Shiming Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Nanomedicine based brain targeting strategies have emerged as a promising avenue for ischemic stroke (IS) treatment. However, conventional approaches face significant challenges in manipulating biodistribution and achieving efficient to attain adequate therapeutic effects. Here, this limitation is overcame by developing magnetic field driven, mitochondria‐targeted ceria nanosystem (MMTCe) nanosystem. By anchoring nanoparticles the cell membrane, targeted delivery of achieved through use an external field, which turn targets damaged mitochondria repairs microenvironment. MMTCe exhibits superior accumulation within vitro blood barrier (BBB) model rat stroke. This mediates mitochondrial function, thereby inhibiting oxidative stress aberrant activation microglial cells, ultimately inducing rebalancing Complemented favorable biosafety profile, top‐down fabrication provides general strategy diseases informs development magnetically driven systems.

Language: Английский

Citations

3
Impact of symmetry and chain length on the excitonic, electronic, and optical characteristics of Dion-Jacobson phase perovskites DOI
Zhonghai Lin,

Ruiyang Zeng,

Pingjian Wang

et al.

Chemical Physics Letters, Journal Year: 2025, Volume and Issue: unknown, P. 142032 - 142032

Published: March 1, 2025

Language: Английский

Citations

1
Stimuli-responsive polymer-based nanosystems for cardiovascular disease theranostics DOI

Yuying Liu,

Congcong Li, Xiao Yang

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(15), P. 3805 - 3825

Published: Jan. 1, 2024

Stimuli-responsive polymer-based nanosystems have gained significant attention for cardiovascular disease theranostics. This review summarizes various stimuli-responsive used diagnosing and treating diseases.

Language: Английский

Citations

6
Blood‐Brain Barrier‐Penetrating Metal‐Organic Framework Antioxidant Nanozymes for Targeted Ischemic Stroke Therapy DOI Open Access
Qing Chen, Jin Wang, Xiaoxing Xiong

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Overproduction of reactive oxygen species (ROS) during reperfusion in ischemic stroke (IS) severely impedes neuronal survival and results high rates morbidity disability. The effective blood‐brain barrier (BBB) penetration brain delivery antioxidative agents remain the biggest challenge treating reperfusion‐induced cerebrovascular neural injury. In this study, a metal‐organic framework (MOF) nanozyme (MIL‐101‐NH 2 (Fe/Cu)) with ROS scavenging activities to encapsulate neuroprotective agent rapamycin is fabricated decorating exterior BBB‐targeting protein ligands (transferrin), thereby realizing enhanced drug retention controlled release within lesions for synergistic treatment IS. Through receptor‐mediated transcellular pathway, transferrin‐coated MOF nanoparticles achieved efficient transport across BBB targeted accumulation at cerebral injury site mice middle artery occlusion/reperfusion (MCAO/R), wherein nanocarrier exhibited catalytic decomposition into O H ‐responsive release. By its BBB‐targeting, antioxidative, anti‐inflammatory, antiapoptotic properties, nanosystem addressed multiple pathological factors IS realized remarkable effects, leading substantial reduction infarction volume accelerated recovery nerve functions MCAO/R mouse model. This MOF‐based nanomedicine provides valuable design principles therapy multi‐mechanism synergies.

Language: Английский

Citations

6
Impact of Symmetry and Chain Length on the Excitonic, Electronic, and Optical Characteristics of Dion-Jacobson Phase Perovskites DOI
Zhonghai Lin,

Ruiyang Zeng,

Pingjian Wang

et al.

Published: Jan. 1, 2025

Dion-Jacobson (DJ) phase halide perovskites have garnered significant attention for their excellent chemical stability, and charge transfer properties. As the ligand asymmetry increases, band gap increases (PDA-DMPD-N-MPDA). The partial density of states indicates that contribution is related [PbI6]4- octahedrons. distribution excitons closely linked to near CBM VBM. excitonic properties reveal maximum exciton binding energies (PDAPbI4-DMPDPbI4-N-MPDAPbI4, 0.048-0.259-0.273 eV), which are consistent with changes in organic chain length. absorption spectra shows asymmetric ligands exhibit better light visible region.

Language: Английский

Citations

0
Biomimetic Cerium‐Assisted Supra‐Carbon Dots Assembly for Reactive Oxygen Species‐Activated Atherosclerosis Theranostic DOI Open Access

Qiao Chen,

Yang Xu,

Yao Yu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Theranostic applications in atherosclerosis plaque microenvironment‐triggered nanoplatforms are significantly compromised by the complex synthesis procedure, non‐specific distribution, and limited therapeutic function. Therefore, development of a facile feasible method to construct pathology‐based stimuli‐responsive nanoplatform with satisfactory theranostic performance remains demanding highly anticipated goal. Herein, novel class multifunctional supra‐carbon dots (CDs), denoted as MM@Ce‐CDs NPs, simple nanoassembly subsequent coating macrophage membrane (MM), is developed for targeted reactive oxygen species‐trigged positive regulation pathological microenvironment AS. The harvested NPs exhibit activatable fluorescence properties, photoacoustic characteristics, cascade enzyme performances, which can be effectively activated under ROS stimulation microenvironment, enabling precise control over functions, while markedly enhancing diagnostic accuracy efficacy AS management. Besides, manipulate reducing levels inflammation, alleviating M1 infiltration, inhibiting foam cell formation, all together suppressing through synergistic mechanisms. In addition, inherit biomimetic biological functions from MM, facilitating specific target delivery

Language: Английский

Citations

0
A balanced view of ion migration in halide perovskite electronics DOI
Feng Li, Yuhang Liang, Rongkun Zheng

et al.

Newton, Journal Year: 2025, Volume and Issue: 1(3), P. 100096 - 100096

Published: May 1, 2025

Language: Английский

Citations

0