Recent Advances in Nanoenzymes Based Therapies for Glioblastoma: Overcoming Barriers and Enhancing Targeted Treatment

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor originating from glial cells, characterized by high recurrence rates poor patient prognosis. The heterogeneity complex biology of GBM, coupled with the protective nature blood–brain barrier (BBB), significantly limit efficacy traditional therapies. rapid development nanoenzyme technology presents promising therapeutic paradigm for rational targeted treatment GBM. In this review, underlying mechanisms GBM pathogenesis are comprehensively discussed, emphasizing impact BBB on strategies. Recent advances in nanoenzyme‐based approaches therapy explored, highlighting how these nanoenzymes enhance various modalities through their multifunctional capabilities potential precise drug delivery. Finally, challenges prospects translating laboratory research to clinical application, including issues stability, targeting efficiency, safety, regulatory hurdles critically analyzed. By providing thorough understanding both opportunities obstacles associated therapies, future directions aimed be informed contribute more effective treatments

Language: Английский

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Cell Membrane-derived Nanovesicles as Extracellular Vesicle-mimetics in Wound Healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101595 - 101595

Published: Feb. 19, 2025

Language: Английский

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Mitochondria in brain diseases: Bridging structural-mechanistic insights into precision-targeted therapies

Published: Feb. 1, 2025

Language: Английский

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Magnetic Field Driven Ceria Nanosystems for Mitochondria Targeted Therapy of Ischemic Stroke

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Nanomedicine based brain targeting strategies have emerged as a promising avenue for ischemic stroke (IS) treatment. However, conventional approaches face significant challenges in manipulating biodistribution and achieving efficient to attain adequate therapeutic effects. Here, this limitation is overcame by developing magnetic field driven, mitochondria‐targeted ceria nanosystem (MMTCe) nanosystem. By anchoring nanoparticles the cell membrane, targeted delivery of achieved through use an external field, which turn targets damaged mitochondria repairs microenvironment. MMTCe exhibits superior accumulation within vitro blood barrier (BBB) model rat stroke. This mediates mitochondrial function, thereby inhibiting oxidative stress aberrant activation microglial cells, ultimately inducing rebalancing Complemented favorable biosafety profile, top‐down fabrication provides general strategy diseases informs development magnetically driven systems.

Language: Английский

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Nanoodor Particles Deliver Drugs to Central Nervous System via Olfactory Pathway

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Central nervous system (CNS) disorders confront significant challenges in drug delivery due to the blood-brain barrier (BBB). Inspired by rapid and precise binding of odor molecules olfactory receptors (ORs), this research uses thiolated HPMA construct nanoparticles (nanoodors) capable delivering drugs CNS via olfacto-cerebral pathway overcome obstruction. The nanoodor core is used encapsulate agomelatine (AGO), a CNS-targeting antidepressant, encapsulation efficiency exceeded 80%. A series thiol-presenting nanoscale structures with different surface densities thiol groups are constructed, effectiveness positively correlated density on their surface. Notably, nanoodors enable brain-targeted delivery, outperforming commercially available oral formulations terms accumulation brain antidepressant effects. study transport action mechanisms revealed that after ORs, rapidly delivered pathway. Nanoodors, first design deliver mimicking natural smells for treatment disorders, expected achieve clinical transformation, benefiting human health.

Language: Английский

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Application of biomimetic nanovaccines in cancer immunotherapy: A useful strategy to help combat immunotherapy resistance

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 75, P. 101098 - 101098

Published: June 1, 2024

Language: Английский

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Advanced Nano Delivery System for Stem Cell Therapy for Alzheimer's Disease

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122852 - 122852

Published: Sept. 30, 2024

Language: Английский

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Apelin-13-Loaded Macrophage Membrane-Encapsulated Nanoparticles for Targeted Ischemic Stroke Therapy via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9175 - 9193

Published: Sept. 1, 2024

Ischemic stroke is a refractory disease wherein the reperfusion injury caused by sudden restoration of blood supply main cause increased mortality and disability. However, current therapeutic strategies for inflammatory response induced cerebral ischemia-reperfusion (I/R) are unsatisfactory. This study aimed to develop functional nanoparticle (MM/ANPs) comprising apelin-13 (APNs) encapsulated in macrophage membranes (MM) modified with distearoyl phosphatidylethanolamine-polyethylene glycol-RVG29 (DSPE-PEG-RVG29) achieve targeted therapy against ischemic stroke.

Language: Английский

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Nano-enhanced nature medicine for ischemic stroke: Opportunities and challenges

Biomedical Technology, Journal Year: 2024, Volume and Issue: 7, P. 32 - 45

Published: July 16, 2024

Ischemic stroke (IS), a major cause of death and disability globally, requires innovative therapeutic approaches due to its complex pathology. Nature medicine (NM) offers promising treatments through bioactive compounds, which target the multifaceted nature stroke-induced damage. However, clinical application NM is limited by challenges in bioavailability specificity. This review article presents an advanced perspective on integrating nanotechnology with create potent nanodelivery systems for ischemic treatment. We highlight pathological underpinnings stroke, including oxidative stress, inflammation, apoptosis, discuss how compounds offer targeted mitigation strategies. By incorporating platforms, such as liposomes nanoparticles, these -based can achieve enhanced targeting, solubility, controlled release, significantly improving outcomes while reducing side effects. Despite developments, translation nano-enhanced into practice faces obstacles, manufacturing scalability, regulatory approval, safety evaluations. emphasizes potential combining advance therapy, calling integrated research efforts overcome existing barriers fully realize benefits this approach.

Language: Английский

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Carcinoma–Astrocyte Gap Junction Interruption by a Dual-Targeted Biomimetic Liposomal System to Attenuate Chemoresistance and Treat Brain Metastasis

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Brain metastasis contributes substantially to the morbidity and mortality of various malignancies is characterized by high chemoresistance. Intracellular communication between carcinoma cells astrocytes through gap junctions, which are assembled mainly connexin 43 protein, has been shown play a vital role in this process. However, effectively blocking junctions two cell types remains extremely challenging because insufficient drug delivery target site. Herein, we designed blocker-carbenoxolone (CBX)-loaded biomimetic liposomal system with artificial liposomes fused brain metastatic reactive astrocyte membranes (LAsomes) block attenuate LAsomes penetrated blood–brain barrier via semaphorin 4D (SEMA 4D)─Plexin B1 interactions actively migrated their source homotypic recognition. Consequently, inhibited material transfer Ca2+ flow from thereby markedly increasing sensitivity tumor chemotherapy. These results reveal that closing may be promising therapeutic strategy for intractable metastasis.

Language: Английский

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