Melanin-Deferoxamine Nanoparticles Targeting Ferroptosis Mitigate Acute Kidney Injury via RONS Scavenging and Iron Ion Chelation DOI
Jinghua Sun, H. F. Shen, Jie Dong

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 282 - 296

Published: Dec. 20, 2024

Rhabdomyolysis (RM)-induced acute kidney injury (AKI) involves the release of large amounts iron ions from excess myoglobin in kidneys, which mediates overproduction reactive species with onset overload via Fenton reaction, thus inducing ferroptosis and leading to renal dysfunction. Unfortunately, there are no effective treatments for AKI other than supportive care. Herein, we developed a multifunctional nanoplatform (MPD) by covalently bonding melanin nanoparticles (MP NPs) deferoxamine. The has good dispersion physiological stability, excellent chelating performance ions, broad-spectrum scavenging activity. Furthermore, cellular experiments showed that NPs possessed high biocompatibility, antiapoptotic activity, antioxidant properties, strong capacity Fe2+ mitigate overload, protecting intracellular mitochondria oxidative stress. Meanwhile, intrinsic photoacoustic imaging capability allows real-time monitoring MPD NPs' target uptake metabolic behavior healthy mice. Most importantly, led downregulation pathway targeting ferroptosis, effectively rescuing function vivo, mitigating stress inflammatory responses, inhibiting tubular cell apoptosis. offers novel therapeutic strategy RM-induced AKI.

Language: Английский

Current and promising applications of UiO-based MOFs in breast cancer therapy DOI
Jiaxin Ma, Zhi‐Min Chen,

Yingyao Diao

et al.

Reactive and Functional Polymers, Journal Year: 2024, Volume and Issue: 200, P. 105918 - 105918

Published: April 25, 2024

Language: Английский

Citations

10
Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma DOI Creative Commons
Iasmina Marcovici, Raul Chioibaş, István Zupkó

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 6, 2025

Despite its rarity, cutaneous melanoma (CM) represents the deadliest skin cancer with a high mortality rate, an incidence on rise, and limited therapeutic options at present. Melanin is polymeric pigment naturally produced within melanocytes CM cells that gained noteworthy attention due to pharmacological properties, potential for design of nanoplatforms biomedical applications. Up date, utilization melanin-like nanoparticles (MEL-NPs) in treatment has been well-documented, although their efficacy therapy remains scarcely investigated. The current study presents preclinical evaluation MEL-NPs as nanomedicine management. were through oxidative polymerization dopamine characterized via electron microscopy UV-VIS spectroscopy. antioxidant activity was determined by using DPPH method. cytotoxic, anti-migratory, anti-clonogenic, pro-oxidant pro-apoptotic properties investigated vitro applying MTT viability test, bright-field immunofluorescence microscopy, DCFDA/H2DCFDA scratch assay, colony formation RT-qPCR. irritant anti-angiogenic effects assessed ovo vascularized chorioallantoic membrane (CAM). as-made presented spherical morphology, average size 85.61 nm, broad absorption spectrum, strong activity. After 24 h treatment, exerted selective cytotoxicity SH-4 B164A5 compared HEMa, HaCaT, JB6 Cl 41-5a healthy cells, except concentration 100 µg/mL, which declined under 70%. Additionally, accumulated intracellular space forming perinuclear coating, inhibited motility clonogenic potential, increased stress, targeted epithelial-to-mesenchymal transition, induced apoptosis altering cell nuclear aspect, F-actin tubulin distribution, modulating expression pro- anti-apoptotic markers. In ovo, lacked vascular toxic effects, while exerting angio-suppressive demonstrated promising anti-melanoma showing cytotoxicity, anti-invasive effect inhibiting CAM angiogenesis, these novel findings contributing future research application this nanoplatform therapy.

Language: Английский

Citations

1
Enhancing tumor endothelial permeability using MUC18-targeted gold nanorods and mild hyperthermia DOI

Xiao Yu,

Jinyuan Liu, Aaron M. Bauer

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 676, P. 101 - 109

Published: July 14, 2024

Language: Английский

Citations

5
Isoforskolin, adenylate cyclase agonist, inhibits endothelial-to-mesenchymal transition in atherosclerosis DOI

Yiming Ma,

Yunke Shi,

Jinping Lun

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156520 - 156520

Published: Feb. 16, 2025

Language: Английский

Citations

0
Tumor Metastasis: Mechanistic Insights and Therapeutic Intervention DOI Creative Commons

Lin Tang,

Peng Shen, Xiaoying Zhuang

et al.

MedComm – Oncology, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 17, 2025

ABSTRACT Metastasis remains a leading cause of cancer‐related deaths, defined by complex, multi‐step process in which tumor cells spread and form secondary growths distant tissues. Despite substantial progress understanding metastasis, the molecular mechanisms driving this development effective therapies remain incompletely understood. Elucidating pathways governing metastasis is essential for discovery innovative therapeutic targets. The rapid advancements sequencing technologies expansion biological databases have significantly deepened our drivers associated drug resistance. This review focuses on particularly roles genetic mutations, epigenetic changes, post‐translational modifications progression. We also examine how microenvironment influences metastatic behavior explore emerging strategies, including targeted immunotherapies. Finally, we discuss future research directions, stressing importance novel treatment approaches personalized strategies to overcome improve patient outcomes. By integrating contemporary insights into basis innovation, provides comprehensive framework guide clinical cancer.

Language: Английский

Citations

0
Erianin Induces Apoptosis of Osteosarcoma Cells Through Ferroptosis Signaling Pathway, and Inhibits Proliferation and Migration of Osteosarcoma Cells DOI Creative Commons

Beilei Yu,

Shu Feng, Zhongzhe Li

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Purpose Erianin plays a certain role in the treatment of tumors, inflammation, diabetes nephropathy, retinopathy and other diseases. However, impact mechanism on osteosarcoma(OS) are still unclear. This article aims to investigate action OS. Methods Animal experiments were conducted using nude mice vivo effects Investigations into vitro OS through cell utilizing MG-63 U-2 human lines. Firstly, use 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay detect viability calculate IC50. Using colony-formation inhibitory effect proliferation. Use wound healing migration cells. flow cytometry apoptosis. Observe survival cells under microscope Acridine Orange/Propidium Iodide(AO/PI)‌ staining. glutathione detection kit ferroptosis signaling pathway Verify protein expression western blot. Results In vitro, inhibits proliferation by regulating cyclin apoptotic proteins, leading cells; vivo, can also tumor growth cause Conclusion The findings Erianin's induction apoptosis ferroptosis, as well its inhibition cells, point it potential therapeutic agent for that warrants further investigation.

Language: Английский

Citations

0
Poly-T-Modified Gold Nanorods Suppress Macrophage-Mediated Inflammation for Periodontitis Therapy DOI

Wanghong He,

Wei Wei, Yifan Zhao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Traditional treatments for periodontitis are limited by their inability to adequately modulate the immune response and control inflammation. Recently, nucleic acid-modified nanomaterials have attracted significant attention potential in regulating Among these, most nanomaterials, such as spherical acids, tend exhibit pro-inflammatory effects. In this study, we identified first time that poly-T sequence-modified gold nanorods (PTM AuNRs) possess anti-inflammatory properties. The PTM AuNRs demonstrated excellent biocompatibility efficacy treating ligation-induced periodontitis. responses inhibiting differentiation of M1 macrophages reducing cytokine levels through promoting AMPK activation. When administered via local injection, effectively suppress inflammatory cell infiltration, downregulate levels, mitigate collagen fiber degradation alveolar bone loss. Together, these findings highlight a promising innovative therapeutic strategy management.

Language: Английский

Citations

0
Three musketeers of PDA-based MRI contrasting and therapy DOI Creative Commons
Magdalena J. Bigaj-Józefowska, Tomasz Zalewski, Karol Załęski

et al.

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 321 - 333

Published: May 25, 2024

Polydopamine (PDA) stands as a versatile material explored in cancer nanomedicine for its unique properties, offering opportunities multifunctional drug delivery platforms. This study explores the potential of utilizing one-pot synthesis to concurrently integrate Fe, Gd and Mn ions into porous PDA-based theranostic platforms called Ferritis, Gadolinis Manganis, respectively. Our investigation spans morphology, magnetic photothermal characteristics cytotoxicity profiles those potent nanoformulations. The obtained structures showcase spherical robust response promising behaviour. All presented nanoparticles (NPs) display pronounced paramagnetism, revealing contrasting MRI imaging. Relaxivity values, key determinant contrast efficacy, demonstrated competitive or superior performance compared established, used agents. These nanoformulations also exhibited properties under near infra-red irradiation, showcasing their possible application therapy cancer. findings provide insights metal-doped PDA NPs theranostics.

Language: Английский

Citations

1
Controlled Hierarchical Construction of Ultrahomogeneous Co9S8@CoAl-LDH/NF Layered Core–Shell Heterostructures for High-Performance Asymmetric Supercapacitors DOI
Yan Yue,

Wenrui Wu,

Yang Yang

et al.

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

The rational collocation and construction of multiphase composite electrode materials with ingenious structures is a key strategic to enhance the electrochemical performance supercapacitors (SCs). Within this project, unique Co9S8@CoAl-LDH/NF core–shell heterostructure consisting CoAl-LDH/NF ultrathin nanosheets sturdily attached Co9S8/NF needle-like nanorods grown in situ on self-supported conductive substrate nickel foam (NF) by an effortless productive multistep hydrothermal method. structure can effectively capacitive properties as well mechanical strength material. Compared single-component (1769.6 mF cm–2 91.6%) (858 85.2%), composites have excellent capacitance (5052.4 cm–2) along exceptional retention (5000 cycles) 98.5% even after undergoing charging discharging. Furthermore, asymmetric SCs fabricated AC/NF exhibit energy density 0.17 mWh at 3.20 mW cm–2. Therefore, innovative presented study holds immense practical potential groundbreaking material realm SCs.

Language: Английский

Citations

1
TTK Inhibition Alleviates Postinjury Neointimal Formation and Atherosclerosis DOI Creative Commons

Jiehong Wu,

Yu‐Xiao Liu,

Jiabin Zong

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Atherosclerosis and its associated cardio-cerebrovascular complications remain the leading causes of mortality worldwide. Current lipid-lowering therapies reduce only approximately one-third cardiovascular risk. Furthermore, vascular restenosis thrombotic events following surgical interventions for severe stenosis significantly contribute to treatment failure. This highlights urgent need novel therapeutic targets manage atherosclerosis prevent thrombosis after injury. study identifies TTK protein kinase (TTK) as a key regulator smooth muscle cell (VSMC) phenotypic switching in context postinjury neointimal formation atherosclerosis. Mechanistically, upregulation VSMCs phosphorylates p120-catenin, β-catenin nuclear accumulation dissociation myocardin (MYOCD)/serum response factor (SRF) complex. Deletion specifically reduces injury models attenuates atherosclerotic lesions ApoE

Language: Английский

Citations

1