Implantable Immunostimulant Microneedle Patch for Post-Surgical Prevention of Cancer Recurrence and Distant Tumor Inhibition DOI
Zichao Luo, Xinchao Li,

Dandan Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Cancer recurrence after surgical resection remains a grand challenge in achieving long-term eradication. Here, we develop biocompatible and implantable immunostimulant microneedle patch designed to suppress local tumor surgery. The patch, fabricated using methacrylate-modified hyaluronic acid, incorporates 2'3'-cGAMP, STING agonist, IL-2, cytokine approved for clinical cancer immunotherapy that expands T cells. enables controlled release of cGAMP induce dendritic cell maturation, antitumor macrophage polarization (M1 macrophage), priming activation. Simultaneously, localized IL-2 activates CD8+ cells recruits immune the microenvironment. When combined with an anti-CTLA-4 antibody, checkpoint blockade, hybrid significantly reduces Treg at surgery sites, enhancing responses effectively inhibiting progression distant tumors both prophylactic therapeutic models. Compared traditional postsurgical chemotherapy radiotherapy, this patch-mediated demonstrates superior efficacy mitigating relapse while offering higher biocompatibility. Our findings suggest immunotherapeutic has potential as translational tool prevent patients resectable tumors.

Language: Английский

Emerging roles of hyaluronic acid hydrogels in cancer treatment and wound healing: A review DOI
Gang Wu,

Chunyan Zhong,

Xiaohui Tian

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140442 - 140442

Published: Jan. 1, 2025

Language: Английский

Citations

0
Recent Advances in Polysaccharide-Based Hydrogels for Tumor Immunotherapy DOI Creative Commons
Ya Zhou, Kaizhao Chen, Hongwei Cheng

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 152 - 152

Published: Feb. 20, 2025

Immunotherapy has revolutionized cancer treatment and led to a significant increase in patient survival rates quality of life. However, the effectiveness current immunotherapies is limited by various factors, including immune evasion mechanisms serious side effects. Hydrogels are type medical material with an ideal biocompatibility, variable structure, flexible synthesis method, physical properties. have long been recognized used as superior choice for biomedical applications. The fascinating results were derived from both vitro vivo models. rapid expansion this area suggests that principles uses functionalized polysaccharides transformative, motivating researchers investigate novel polysaccharide-based hydrogels wider Polysaccharide proven be practicable delivery strategy tumor immunotherapy due their biodegradability, pronounced bioactive characteristics. This study aims examine detail latest developments polysaccharide immunotherapy, focusing on design, mechanism action, potential therapeutic

Language: Английский

Citations

0
Dual-targeted alpha therapy mitigates prostate cancer and boosts immune checkpoint blockade therapy DOI
Juan Sun, Jiangtao Yang,

Jiakun Guo

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113686 - 113686

Published: April 1, 2025

Language: Английский

Citations

0
Implantable Immunostimulant Microneedle Patch for Post-Surgical Prevention of Cancer Recurrence and Distant Tumor Inhibition DOI
Zichao Luo, Xinchao Li,

Dandan Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Cancer recurrence after surgical resection remains a grand challenge in achieving long-term eradication. Here, we develop biocompatible and implantable immunostimulant microneedle patch designed to suppress local tumor surgery. The patch, fabricated using methacrylate-modified hyaluronic acid, incorporates 2'3'-cGAMP, STING agonist, IL-2, cytokine approved for clinical cancer immunotherapy that expands T cells. enables controlled release of cGAMP induce dendritic cell maturation, antitumor macrophage polarization (M1 macrophage), priming activation. Simultaneously, localized IL-2 activates CD8+ cells recruits immune the microenvironment. When combined with an anti-CTLA-4 antibody, checkpoint blockade, hybrid significantly reduces Treg at surgery sites, enhancing responses effectively inhibiting progression distant tumors both prophylactic therapeutic models. Compared traditional postsurgical chemotherapy radiotherapy, this patch-mediated demonstrates superior efficacy mitigating relapse while offering higher biocompatibility. Our findings suggest immunotherapeutic has potential as translational tool prevent patients resectable tumors.

Language: Английский

Citations

0