Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 17, 2024
Currently,
pulmonary
complications
such
as
lung
infections
during
the
perioperative
period
are
still
main
cause
of
prolonged
hospitalization
and
death
in
patients
with
injury
due
to
lack
effective
drugs.
Clusterzyme,
a
kind
artificial
enzyme
high
enzyme-like
activity
safety
profile,
exhibits
good
effects
on
reducing
oxidative
stress
immunomodulation.
Here,
we
present
functionalized
patches
that
is
administered
airways
rescues
injured
organ
via
clusterzymes.
The
long-term
antioxidant
capacity
significantly
ameliorated
lipopolysaccharide-induced
function
impairment
significant
reduction
goblet
cell
metaplasia
stress.
inflammatory
factors
cytokines
interleukin-1β,
interleukin-6,
tumor
necrosis
factor-α
levels
decreased
by
50%,
while
mtDNA
copy
number
increased
50%
ATP
production
100%.
Mice
was
improved,
suggesting
can
rescue
modulating
immune
responses
well
protecting
mitochondria,
providing
an
avenue
for
intervention
injury.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Spinal
cord
injury
(SCI)
is
a
severe
clinical
disease
usually
accompanied
by
activated
glial
scar,
neuronal
axon
rupture,
and
disabled
motor
function.
To
mimic
the
microenvironment
of
SCI
site,
hydrogel
system
with
comparable
mechanical
property
to
spinal
desirable.
Therefore,
novel
elastic
bovine
serum
albumin
(BSA)
fabricated
excellent
adhesive,
injectable,
biocompatible
properties.
The
used
deliver
paclitaxel
(PTX)
together
basic
fibroblast
growth
factor
(bFGF)
inhibit
scar
formation
as
well
promote
regeneration
function
for
repair.
Due
specific
interaction
BSA
both
drugs,
bFGF,
PTX
can
be
controllably
released
from
achieve
an
effective
concentration
at
wound
site
during
process.
Moreover,
benefiting
combination
this
bFGF/PTX@BSA
significantly
aided
repair
promoting
elongation
axons
across
reduced
reactive
astrocyte
secretion.
In
addition,
remarkable
anti-apoptosis
nerve
cells
evident
system.
Subsequently,
multi-functionalized
drug
improved
rats
after
SCI.
These
results
reveal
that
ideal
functionalized
material
in
Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 17, 2024
Currently,
pulmonary
complications
such
as
lung
infections
during
the
perioperative
period
are
still
main
cause
of
prolonged
hospitalization
and
death
in
patients
with
injury
due
to
lack
effective
drugs.
Clusterzyme,
a
kind
artificial
enzyme
high
enzyme-like
activity
safety
profile,
exhibits
good
effects
on
reducing
oxidative
stress
immunomodulation.
Here,
we
present
functionalized
patches
that
is
administered
airways
rescues
injured
organ
via
clusterzymes.
The
long-term
antioxidant
capacity
significantly
ameliorated
lipopolysaccharide-induced
function
impairment
significant
reduction
goblet
cell
metaplasia
stress.
inflammatory
factors
cytokines
interleukin-1β,
interleukin-6,
tumor
necrosis
factor-α
levels
decreased
by
50%,
while
mtDNA
copy
number
increased
50%
ATP
production
100%.
Mice
was
improved,
suggesting
can
rescue
modulating
immune
responses
well
protecting
mitochondria,
providing
an
avenue
for
intervention
injury.
