MOF‐Based Guided Bone Regeneration Membrane for Promoting Osteogenesis by Regulating Bone Microenvironment through Cascade Effects DOI

Chunyu Liu,

Yajuan Xie,

Yunfan Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Regulation of bone microenvironment (BME) including innate pH values and metal ions affects cellular functions activities osteoblasts osteoclasts, thereby significantly influencing the process regeneration. How to achieve multiple effective regulations BME through cascade effects via facile material design fabrication facilitate osteogenesis remains a challenge. Herein, facilely‐designed resorbable guided regeneration membrane (PCL/DEX@Ca‐Zol) based on drug‐loaded metal‐organic framework is reported. Thereinto, calcium ions, zoledronic acid, dexamethasone embedded in can be responsively released specifically inside defect an acid‐triggered manner synergistically regulate by neutralization value, enhancement osteogenic differentiation mineralization, inhibition osteoclasts one‐go. Along with polycaprolactone as structural support for fully utilized components composite material, enhances minimized side accordingly achieved assistance modulation effects.

Language: Английский

Three‐dimensional bioprinting biphasic multicellular living scaffold facilitates osteochondral defect regeneration DOI Creative Commons

Xingge Yu,

Mazaher Gholipourmalekabadi, Xudong Wang

et al.

Interdisciplinary materials, Journal Year: 2024, Volume and Issue: 3(5), P. 738 - 756

Published: June 2, 2024

Abstract Due to tissue lineage variances and the anisotropic physiological characteristics, regenerating complex osteochondral tissues (cartilage subchondral bone) remains a great challenge, which is primarily due distinct requirements for cartilage bone regeneration. For regeneration, significant amount of newly generated chondrocytes required while maintaining their phenotype. Conversely, regeneration necessitates inducing stem cells differentiate into osteoblasts. Additionally, construction interface crucial. In this study, we fabricated biphasic multicellular bioprinted scaffold mimicking natural employing three‐dimensional (3D) bioprinting technology. Briefly, gelatin‐methacryloyl (GelMA) loaded with articular marrow mesenchymal (ACs/BMSCs), serving as layer, preserved phenotype ACs promoted differentiation BMSCs through interaction between BMSCs, thereby facilitating GelMA/strontium‐substituted xonotlite (Sr‐CSH) regulated osteoblasts enhanced secretion matrix by in layer slow release bioactive ions from Sr‐CSH. GelMA, material, contributed reconstruction interface. Ultimately, demonstrated satisfactory simultaneous defects. promising strategy application 3D technology was proposed.

Language: Английский

Citations

18
A moldable hydrogel based on sericin and Zn2+/F- dual-doped hydroxyapatite promotes skull defect repair through the synergistic effects of immunoregulation, enhanced angiogenesis and osteogenesis DOI
Jiaxin Yao, Changjin Huang, Jialing Yao

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 491, P. 151789 - 151789

Published: April 29, 2024

Language: Английский

Citations

8
Synergistic Functions of the Janus Fibrous Membrane for Enhanced Bone Repair DOI
Tingting Zhang, Jinghong Yang, Yu Lu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

The treatment of bone defects presents significant challenges in clinical practice. Guided regeneration (GBR) strategies offer a new approach, but existing commercial GBR membranes still lack optimal barrier and osteogenic functions. This study the design Janus fibrous membrane using classic amphiphilic block copolymers gelatin methacryloyl containing unsaturated double bonds through gradient electrospinning process. Specifically, by controlling parameters, self-assembly copolymers, secondary photo-cross-linking, differential composition, topological structure, properties between different layers were achieved, thereby realizing synergistic physiological repair-promoting By leveraging effect, it effectively blocks adverse effects soft tissue cell ingrowth on repair while guiding proliferation differentiation. Furthermore, membrane's functionality is optimized incorporating antimicrobial component ε-poly-l-lysine niobium. In vivo studies demonstrate excellent biocompatibility, antibacterial activity, remarkable potential both normal infectious defect animal models. developed serves as versatile platform for biomedical applications, offering vast to address limitations current treatment.

Language: Английский

Citations

1
Low-Intensity Pulsed Ultrasound Responsive Scaffold Promotes Intramembranous and Endochondral Ossification via Ultrasonic, Thermal, and Electrical Stimulation DOI

Wanru Jia,

Tianlong Wang, Feng Chen

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: 19(4), P. 4422 - 4439

Published: Jan. 21, 2025

Multiple physical stimuli are expected to produce a synergistic effect promote bone tissue regeneration. Low-intensity pulsed ultrasound (LIPUS) has been clinically used in repair for the mechanical stimulation that it provides. In addition, LIPUS can also excite biomaterials generate other such as thermal or electrical stimuli. this study, scaffold based on decellularized adipose (DAT) is established by incorporating polydopamine-modified multilayer black phosphorus nanosheets (pDA-mBP@DAT). Their under and potential mechanisms further investigated. This possesses piezoelectric properties generates mild thermogenic stimulus when stimulated LIPUS. With superior properties, demonstrated have good cytocompatibility vitro vivo. Simultaneously, promotes cell attachment, migration, osteogenic differentiation pDA-mBP@DAT scaffold. Furthermore, combined use of significantly affects regenerative rat models critical-sized calvarial defects. The possible include promoting osteogenesis neovascularization activating Piezo1. study presents insight into speeding up regeneration combination scaffolds.

Language: Английский

Citations

0
Dose-dependent enhancement of in vitro osteogenic activity on strontium-decorated polyetheretherketone DOI Creative Commons
Yongheng Zhang,

Lvhua Liu,

Mengqi Li

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 24, 2025

Polyetheretherketone (PEEK) is widely used in orthopedic and dental implants due to its excellent mechanical properties, chemical stability, biocompatibility. However, inherently bioinert nature makes it present weak osteogenic activity, which greatly restricts clinical adoption. Herein, strontium (Sr) incorporated onto the surface of PEEK using mussel-inspired polydopamine coating improve activity. X-ray photoelectron spectroscopy ion release assay results confirm that different concentrations Sr are substrate surfaces. The strontium-modified samples show a stable 35 days detection. Better MC3T3-E1 pre-osteoblasts adhesion, spreading, proliferation can be observed groups, demonstrates with improved compatibility. boosted activity has been demonstrated by better performed ALP extracellular matrix mineralization, collagen secretion, remarkable up-regulation ALP, OCN, OPN, Runx2, Col-I, BSP, OSX pre-osteoblasts. Additionally, exhibit dose-dependent enhancement osteoblasts compatibility PEEK-Sr10 group shows best. These findings indicate strontium-decorated promising application implants.

Language: Английский

Citations

0
A Coordinated Cascade Therapy‐Based Janus Fibrous Membrane Drives Bone Regeneration through Mediating the Transformation of Energy Metabolism Pathway DOI Open Access

X. Cheng,

Na Xu,

Hao Wu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Bone regeneration is synergistically regulated by growth factors, which are expressed in a coordinated cascade of events. An ideal guided bone membrane (GBRM) shall present barrier and antibacterial functions, promote osteogenesis through time‐controlled release factors. In this study, therapy‐based Janus fibrous fabricated coaxial electrospinning layer‐by‐layer self‐assembly technology (LBL). Specifically, the oriented PCL/PLGA fibers loaded with zinc oxide nanoparticles (ZnO NPs) designed as outer layer, randomly arranged core‐shell Gelatin/PLLA nanofibers employed inner layer to rapidly aFGF sustainedly BMP‐2. Results demonstrated that achieved multiple functions satisfy essential requirement regeneration, exhibited remarkable ability, function, osteoinductive ability. Interestingly, significant enhancement oxidative phosphorylation (OXPHOS) major energy supply pathway decisive factor drive osteogenic differentiation BMSCs induced membranes. This study provides novel strategy fabricate multifunctional membranes/scaffolds, displaying great potential applications tissue engineering. Besides, understanding synergistic mechanism factors on cellular metabolism process can provide deeper insights into factors‐mediated optimizing healing outcomes.

Language: Английский

Citations

0
Advances in Shape‐Memory Polymers and Composites for Biomedical Device Applications DOI Open Access

Chengjun Zeng,

Liwu Liu, Wei Zhao

et al.

Advanced Engineering Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Over the past two decades, remarkable advancements have been achieved in stimulus‐responsive shape‐memory polymers (SMPs), which exhibit desirable properties such as characteristics, deformability, and biocompatibility, while responding to external stimuli. The development of polymer composites (SMPCs) leads high recovery forces novel functionalities, including electrical actuation, magnetic biocompatibility. enhanced remotely controllable functionality further expand application SMPs biomedical areas, surgical applications for replacing handheld instruments drug delivery systems. In this review, device SMPCs are focused on their recent bone tissue scaffolds, lumen stents, carriers examined. Furthermore, bottlenecks challenges encountered by devices elucidated. future trend is also discussed, aiming provide valuable insights broadening fields.

Language: Английский

Citations

0
Osteomimix: A Multidimensional Biomimetic Cascade Strategy for Bone Defect Repair DOI Open Access
Xiaoyi Wu,

Yang Hongye,

Gufeng Liu

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Despite advancements in biomimetic mineralization techniques, the repair of large-scale bone defects remains a significant challenge. Inspired by formation process, multidimensional cascade strategy is developed replicating biomineralization cascade, emulating hierarchical structure bone, and biomimicking its biological functions for efficient regeneration. This involves photocrosslinking sodium methacrylate carboxymethyl cellulose-stabilized amorphous magnesium-calcium phosphate with methacrylate-modified type I collagen to create self-mineralizing hydrogel. The hydrogel then integrated either naturally derived or synthetic oriented bulk scaffolds. resulting composite, named Osteomimix, provides excellent mechanical support can be customized irregular using CAD/CAM technology. Through vitro vivo studies, this work finds that Osteomimix exhibits spontaneous situ cell-free environment, while modulating immune responses promoting vascularized cell-dependent manner. Built on bone-specific insights, achieves biomimicry across temporal, spatial, functional dimensions, facilitating seamless integration artificial constructs natural tissue dynamics.

Language: Английский

Citations

0
Recent advances in tailored chitosan-based hydrogels for bone regeneration and repair DOI
Peipei Feng,

Chaonan He,

Guanrong Li

et al.

Materials Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This paper summarizes the preparation processes of tailored chitosan-based hydrogels, along with their specific applications in bone regeneration, aiming to inspire innovative designs for hydrogels and foster expanded applications.

Language: Английский

Citations

0
Implantable Dental Barrier Membranes as Regenerative Medicine in Dentistry: A Comprehensive Review DOI Creative Commons
Siyuan Chen, Zhenzhen Wu, Ziqi Huang

et al.

Tissue Engineering and Regenerative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Abstract Background: Periodontitis and bone loss in the maxillofacial dental areas pose considerable challenges for both functional aesthetic outcomes. To date, implantable barrier membranes, designed to prevent epithelial migration into defects create a favorable environment targeted cells, have garnered significant interest from researchers. Consequently, variety of materials fabrication methods been explored extensive research on regenerative membranes. Methods: This review focuses summarizing various biomaterials used membrane manufacturing, methods, state-of-the-art applications tissue regeneration. Based discussion pros cons current strategies, future directions improved designs are proposed. Results conclusion: endow membranes with biological properties that accommodate different clinical situations, numerous manufacturing These approaches provide theoretical support hold promise advancements

Language: Английский

Citations

0