GSH-responsive and Mitochondria-targeting Multifunctional Nanoplatform for MR imaging-guided enhanced chemotherapy of Glioma by Reshaping the Tumor Immune Microenvironment DOI Creative Commons
Guangrong Zheng, Tengfei Ke, Wen Zhao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Despite considerable progress in glioma research, present therapeutic approaches continue to be insufficiently efficacious, predominantly owing challenging hindrances conveying chemotherapy drugs across the blood-brain barrier (BBB) and reshaping immunosuppressive tumor microenvironment (TME). In this study, a multifunctional nanoplatform was developed comprising poly-lactide-co-glycolide (PLGA) encapsulated with MnO2 nanoparticles, triphenylphosphonium (TPP) conjugated doxorubicin (DOX), Angiopep-2 (Ang) for magnetic resonance imaging-guided enhanced of glioma. The role Ang promotes BBB penetration cell targeting, while TPP allows an increased concentration Ang-PMT NPs mitochondria. Upon exposure high glutathione (GSH) within TME, disintegrate rapidly, resulting production Mn2+ subsequent release DOX. released DOX directly eradicates cells catalyzes mitochondrial DNA release, leading immunogenic death (ICD) activation cGAS-STING pathway. Furthermore, produced also activates pathway, thereby TME enhancing demonstrated notable inhibition growth comparison control groups. It is anticipated that innovative approach may offer promising prospects management malignant clinical management.

Language: Английский

Immunity‐Modulating Metal‐Based Nanomaterials for Cancer Immunotherapy DOI Creative Commons

Xing Sun,

Xican Xu,

Fengying Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Cancer immunotherapy, which leverages the body's immune system to combat cancer, offers promise of lower toxicity and higher therapeutic efficacy compared conventional treatments. However, current immunotherapeutic approaches face significant challenges including variable patient response, immune‐related adverse events, high costs, underscoring urgent need for innovative strategies. Metal‐based nanomaterials have emerged as a promising avenue in cancer immunotherapy due their unique physicochemical properties immune‐regulating capabilities. Despite potential, concerns about toxicity, incomplete understanding modulation mechanisms, early‐stage design strategies hinder clinical translation. This review summarizes recent advancements metal‐based elucidates mechanisms by they enhance antitumor immunity responses, explores potential synergistic effects combining multiple metals. We also discuss key future perspectives application, aiming provide theoretical foundation development immunotherapies promote broader application treatment.

Language: Английский

Citations

0
The fucoidan delivery system enhanced the anti-cervical cancer effect of caffeic acid DOI
Xintao Gao, Tao Jiang, Xiaochen Wu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 141976 - 141976

Published: March 12, 2025

Language: Английский

Citations

0
Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy DOI
Zhen Liu, Wei Hu, Yingying Cai

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 690, P. 137332 - 137332

Published: March 14, 2025

Language: Английский

Citations

0
Unleashing the Potential of Metal Ions in cGAS-STING Activation: Advancing Nanomaterial-Based Tumor Immunotherapy DOI Creative Commons

Xingyin Li,

Shaojie Xu,

Ziliang Su

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Immunotherapy is a critical modality in cancer treatment with diverse activation pathways. In recent years, the stimulator of interferon genes (STING) signaling pathway has exhibited significant potential tumor immunotherapy. This exerts notable antitumor effects by activating innate and adaptive immunity regulating immune microenvironment. Various metal ions have been identified as effective activators STING and, through design synthesis nanodelivery platforms, applied immunotherapy well combination therapies, such chemotherapy, chemodynamic therapy, photodynamic vaccines. Metal nanomaterials showcase unique advantages immunotherapy; however, there are still aspects that require optimization. review systematically examines existing metal-based nanomaterials, elaborates on mechanisms which different activate pathway, discusses their application models therapies. We also provide comparative analysis over other methods. Our exploration highlights broad prospects treatment, offering new insights directions for advancement

Language: Английский

Citations

0
Membrane‐Anchoring and Oxygen‐Generating Mediated Nanosonosensitizer for Optimizing Cancer Immunotherapy DOI Open Access
Qing Zhao,

Ye ji Han,

Wushuang Gong

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Despite its antitumor promise, sonodynamic therapy (SDT)'s efficacy in immune activation requires enhancement, primarily due to the hypoxic tumor microenvironment (TME) and insufficient targeting of sonosensitizers specific subcellular regions. Herein, we developed macrophage membrane (MM)-intermingled fusogenic liposomes (MFL) optimize sonoimmunotherapy that encapsulate catalase (CAT) within core incorporate sonosensitizer chlorin e6 (Ce6) outer shell (CAT@MM-MFL-Ce6). The MM confers evasion properties promotes nanoparticles' targeted accumulation tissue. fusion effect enables Ce6 anchor onto cancer cell facilitates direct delivery CAT into cytoplasm, bypassing endosomal degradation. Upon ultrasound stimulation, generated reactive oxygen species directly damage plasma membrane, initiating Caspase 3/Gasdermin E-mediated pyroptosis pathway. Concurrently, encapsulated efficiently decompose H₂O₂ thus enhancing local levels tumors. Contributed by these effects, combination nanosonosensitizer-augmented SDT checkpoint agent successfully reverse immunosuppressive TME, driving a potent response inhibits primary growth, distant metastasis, lung metastases an orthotopic triple-negative breast model. This study demonstrates potential novel SDT-based combinatorial approach modulate immune-cold TMEs, advancing proof-of-concept therapeutics.

Language: Английский

Citations

0
Engineering Mild‐Photothermal Responsive and NO Donor Prussian Blue Nanozymes Using Mild Synthesis for Inflammation Regulation and Bacterial Eradication in Periodontal Disease DOI Open Access
Zheng Li,

Xiaowan Fan,

Ying Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Periodontitis, an infectious disease of periodontal tissues caused by oral bacterial biofilms, is characterized reactive oxygen species (ROS) accumulation and immune microenvironment imbalance. Multifunctional nanozymes, leveraging their physiochemical properties enzymatic activities, offer promising antibacterial anti-inflammatory strategies for managing periodontitis. In particular, Prussian blue nanozymes (PBzymes) exhibit exceptional ROS control due to robust catalytic activity, diverse antioxidant functions, high biocompatibility. However, the practical application traditional high-temperature synthesis methods limited. This study introduces a class metal-engineered PBzymes synthesized at room temperature, identified potent antioxidative activity excellent photothermal performance mild temperatures. Nitric oxide (NO) gas therapy offers targeting deep infections in tissues. Thus, sodium nitroprusside introduced into PBzyme create SPBzyme via situ loading method. NO release enhances effects overcomes resistance linked resulting mild-photothermal synergistic effects. vitro assays demonstrate superior efficacy under temperature conditions near-infrared light exposure. Furthermore, effectively reduces inflammation has positive therapeutic animal models. Overall, mild-temperature nanozyme represents novel approach treating

Language: Английский

Citations

2
A Poly‐prodrug Nanosphere for Modulating Janus‐faced Nature of Pyroptosis to Launch an Immune Offensive and Defensive Warfare Reigniting the Cancer‐immunity Cycle DOI Open Access

Linlin Han,

Meng‐Jie Zhang,

Mengjie Ye

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Pyroptosis provides a novel perspective for the design of anti‐tumor strategies. However, when pyroptosis reaches plateau, its negative role becomes “defense” signaling to evade immune surveillance. Herein, triblock polymeric micelles TPT@PIO NPs are reported, including hydrophobic block backbone poly (propylene sulfide) (PPS), side chain disulfide bond‐bearing indomethacin (MABHD‐IND), hydrophilic poly(ethylene glycol) methyl ether methacrylate (OEGMA), and an encapsulated drug topotecan (TPT) through forces, exhibit excellent stability responsiveness oxidation‐reduction microenvironment. This dual treatment mode utilizes TPT trigger activation process uses IND eliminate escape by inhibiting COX‐2/PGE 2 pathway, ultimately making growth tumors being inhibited via synergy chemotherapy immunotherapy. Furthermore, failure immunosuppressive network accelerates infiltration CD8 + T cells into lungs impedes generation tumor nodules. The changes in levels cytokines caused memory effect enhance defense transfer as well. In general, ability regulate Janus‐faced nature acts indispensable suppressing proliferation metastasis.

Language: Английский

Citations

2
Engineering of calcium overload for state-of-the-art tumor therapy DOI
Xinping Liu, Hui Hu, Jinjin Chen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 501, P. 157747 - 157747

Published: Nov. 17, 2024

Language: Английский

Citations

1
2D manganese-doped calcium carbonate nanosheets as activable MRI/US imaging Guided enhanced calcium influx for Boosted regulatory cell death DOI

Mingya Tan,

Linlin Huo,

Jie Zeng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158309 - 158309

Published: Dec. 1, 2024

Language: Английский

Citations

1
Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy DOI Creative Commons
Ying‐Li Luo,

Maoyuan Linghu,

Xianyu Luo

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1