GSH-responsive and Mitochondria-targeting Multifunctional Nanoplatform for MR imaging-guided enhanced chemotherapy of Glioma by Reshaping the Tumor Immune Microenvironment DOI Creative Commons
Guangrong Zheng, Tengfei Ke, Wen Zhao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Despite considerable progress in glioma research, present therapeutic approaches continue to be insufficiently efficacious, predominantly owing challenging hindrances conveying chemotherapy drugs across the blood-brain barrier (BBB) and reshaping immunosuppressive tumor microenvironment (TME). In this study, a multifunctional nanoplatform was developed comprising poly-lactide-co-glycolide (PLGA) encapsulated with MnO2 nanoparticles, triphenylphosphonium (TPP) conjugated doxorubicin (DOX), Angiopep-2 (Ang) for magnetic resonance imaging-guided enhanced of glioma. The role Ang promotes BBB penetration cell targeting, while TPP allows an increased concentration Ang-PMT NPs mitochondria. Upon exposure high glutathione (GSH) within TME, disintegrate rapidly, resulting production Mn2+ subsequent release DOX. released DOX directly eradicates cells catalyzes mitochondrial DNA release, leading immunogenic death (ICD) activation cGAS-STING pathway. Furthermore, produced also activates pathway, thereby TME enhancing demonstrated notable inhibition growth comparison control groups. It is anticipated that innovative approach may offer promising prospects management malignant clinical management.

Language: Английский

STING Drives Pyroptosis and Exacerbates Intestinal Ischemia-Reperfusion Injury DOI Creative Commons
Ke Ding, Yiguo Zhang, Lele Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 15, 2024

Abstract This study aimed to investigate the role of STING (Stimulator Interferon Genes) in intestinal ischemia-reperfusion (IIR) injury, focusing on its impact mitochondrial function, pyroptosis, and inflammation. The utilized both vivo vitro models, including a mouse model IIR organoids subjected hypoxia-reoxygenation (HR). We assessed effects pharmacological inhibition using H.151 knockout injury markers, histological damage, pro-inflammatory cytokine levels, morphology pyroptosis markers. Our findings revealed that significantly upregulated expression epithelium, coinciding with increased permeability, elevated production (IL-1β) (p < 0.05), evidence dysfunction, characterized by reduced ATP disrupted 0.01). Importantly, treatment attenuated IIR-induced damage 0.01), levels preserved function Furthermore, we observed significant reduction as evidenced decreased cleaved gasdermin D H.151-treated groups 0.05). identifies critical mediator likely through activation pathways leading dysfunction pyroptosis. suggest targeting represents promising therapeutic strategy for mitigating following ischemia-reperfusion.

Language: Английский

Citations

0
Micro- and Macronutrients in Endometrial Cancer—From Metallomic Analysis to Improvements in Treatment Strategies DOI Open Access
Gabriela Hunek, Julita Zembala, Jacek Januszewski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9918 - 9918

Published: Sept. 14, 2024

Endometrial cancer is reported to be one of the most prevalent cancers female reproductive organs worldwide, with increasing incidence and mortality rates over past decade. Early diagnosis critical for effective treatment. Recently, there has been a growing focus on role nutrition micronutrient macronutrient status in patients gynecologic cancers, including endometrial cancer. In following paper, we have conducted an in-depth narrative literature review aim evaluating results metallomic studies specifically concerning micro- The main objective paper was analyze regarding nutritional describe chosen elements onset progression carcinogenesis. Further, focused evaluation usage described potential treatment abovementioned cancer, as well possible prevention considering proper supplementation healthy individuals. Calcium proposed reduce risk although some offer conflicting evidence. Deficiencies phosphorus, selenium, zinc inversely associated risk, suggesting they may play protective role, whereas excessive levels iron, copper, cadmium positively correlated increased risk. However, molecular mechanisms by which these affect carcinogenesis are not fully understood, current findings often contradictory. Further research needed clarify relationships evaluate interventions

Language: Английский

Citations

0
Manganese-based nano-delivery system for sensitized anti-tumor immunotherapy via combined autophagy inhibition DOI
Huijuan Zhang, Chenglin Liang, X. H. Ding

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110525 - 110525

Published: Oct. 1, 2024

Language: Английский

Citations

0
Advancements in nano-immunotherapy for gynecological cancers: A new frontier DOI Open Access

Gu Xiao,

Cuicui Wang

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117553 - 117553

Published: Oct. 13, 2024

Language: Английский

Citations

0
GSH-responsive and Mitochondria-targeting Multifunctional Nanoplatform for MR imaging-guided enhanced chemotherapy of Glioma by Reshaping the Tumor Immune Microenvironment DOI Creative Commons
Guangrong Zheng, Tengfei Ke, Wen Zhao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Despite considerable progress in glioma research, present therapeutic approaches continue to be insufficiently efficacious, predominantly owing challenging hindrances conveying chemotherapy drugs across the blood-brain barrier (BBB) and reshaping immunosuppressive tumor microenvironment (TME). In this study, a multifunctional nanoplatform was developed comprising poly-lactide-co-glycolide (PLGA) encapsulated with MnO2 nanoparticles, triphenylphosphonium (TPP) conjugated doxorubicin (DOX), Angiopep-2 (Ang) for magnetic resonance imaging-guided enhanced of glioma. The role Ang promotes BBB penetration cell targeting, while TPP allows an increased concentration Ang-PMT NPs mitochondria. Upon exposure high glutathione (GSH) within TME, disintegrate rapidly, resulting production Mn2+ subsequent release DOX. released DOX directly eradicates cells catalyzes mitochondrial DNA release, leading immunogenic death (ICD) activation cGAS-STING pathway. Furthermore, produced also activates pathway, thereby TME enhancing demonstrated notable inhibition growth comparison control groups. It is anticipated that innovative approach may offer promising prospects management malignant clinical management.

Language: Английский

Citations

0