Cited by Advances in biomaterial-based tissue engineering for peripheral nerve injury repair

Liquid Metal‐Based Conductive Nerve Guidance Conduit Combined With Electrical Stimulation Boosts Peripheral Nerve Repair DOI

Yujie Zhu, Chenchen Song, Dongdong Yao

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2025, Volume and Issue: 113(2)

Published: Feb. 1, 2025

The combination of nerve guide conduits (NGCs) and electrical stimulation (ES) is an effective treatment for peripheral injury (PNI). Flexible conductive materials with mechanical properties similar to those biological tissues have been shown better long-term biointegration functionality than rigid materials. In this study, liquid metal (LM)-based polycaprolactone/gelatin/polypyrrole/LM (PCL/Gel/PPy/LM, PGPL) NGC was combined exogenous ES repair PNI. PGPL membranes had good hydrophilicity, degradability, properties, its conductivity reached 0.66 ± 0.02 S/m. vitro studies showed that the (2 Hz, 100 mV/cm, 30 min/d) could significantly increase expression neuromarkers a pro-neural differentiation effect. vivo demonstrated NGCs in 200 mV/mm, effectively promote morphological reconstruction functional recovery sciatic rats. At 3 months post-surgery, restored conduction velocity 73.85% 5.45% normal value. LM-based prepared study long defects, which may further expand application LM field tissue engineering.

Language: Английский

Citations

Reduce electrical overload via threaded Chinese acupuncture in nerve electrical therapy DOI

Yupu Liu, Yawei Du, Juan Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 476 - 493

Published: Jan. 5, 2025

Language: Английский

Citations

Exogenous Electron Generation Techniques for Biomedical Applications: Bridging Fundamentals and Clinical Practice DOI

Yufei Tang, Shuqi Feng, Keyi Yao

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123083 - 123083

Published: Jan. 5, 2025

Language: Английский

Citations

Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future DOI

Chundi Liu,

Mouyuan Sun,

Lining Lin

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101503 - 101503

Published: Feb. 6, 2025

Peripheral nerve injuries are a prevalent global issue that has garnered great concern. Although autografts remain the preferred clinical approach to repair, their efficacy is hampered by factors like donor scarcity. The emergence of guidance conduits as novel tissue engineering tools offers promising alternative strategy. This review aims interpret and commercialization from both laboratory perspectives. To enhance comprehension situations, this article provides comprehensive analysis approved United States Food Drug Administration. It proposes initial six months post-transplantation critical window period for evaluating efficacy. Additionally, study conducts systematic discussion on research progress conduits, focusing biomaterials add-on strategies pivotal regeneration, supported literature analysis. conduit materials prospective optimal thoroughly discussed. strategies, together with distinct obstacles potentials deeply analyzed. Based above evaluations, development path manufacturing strategy envisioned. conclusion promoting summarized follows: 1) optimization fundamental means; 2) phased application additional emphasized direction; 3) additive techniques necessary tools. As result, findings provide academic practitioners valuable insights may facilitate future endeavors conduits.

Language: Английский

Citations

Microneedles in diabetic wound care: multifunctional solutions for enhanced healing DOI

Xichao Jian,

Y Deng,

Shune Xiao

et al.

Burns & Trauma, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

Abstract Diabetic wounds present a significant challenge in clinical treatment and are characterized by chronic inflammation, oxidative stress, impaired angiogenesis, peripheral neuropathy, heightened risk of infection during the healing process. By creating small channels surface skin, microneedle technology offers minimally invasive efficient approach for drug delivery treatment. This article begins outlining biological foundation normal skin wound unique pathophysiological mechanisms diabetic wounds. It then delves into various types, materials, preparation processes microneedles. The focus is on application multifunctional microneedles treatment, highlighting their antibacterial, anti-inflammatory, immunomodulatory, antioxidant, angiogenic neural repair properties. These demonstrate synergistic therapeutic effects directly influencing microenvironment, ultimately accelerating advancement not only holds promise enhancing outcomes but also new strategies addressing other

Language: Английский

Citations

Self-assembled Nanostructures of Noncovalent Giant Amphiphilic Molecules Composed of Hydrophobic Isobutyl BPOSS and Hydrophilic POM in Different Cosolvents DOI

Fengfeng Feng,

Dongcheng Xiao,

Fan Yang

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

The self-assembly of giant amphiphilic molecules with diverse topological structures has been widely investigated in bulk, solution, and interfacial environments because it can lead to interesting geometric patterns. However, many or their self-assembling units are built by covalent bonds, which may limit the movement molecular blocks, affecting process microstructure. In contrast, noncovalent interactions nanomorphologies nanostructures. this study, we (BPOSS&POM) forming electrostatic between hydrophobic isobutyl polyhedral oligomeric silsesquioxanes (BPOSSs) hydrophilic polyoxometalates (POMs) investigate behavior water/acetone, water/THF, hexane/acetone cosolvents. By controlling solvent parameters, BPOSS&POM self-assembled into nanosheet, nanobelt, nanosphere, nanocrumb structures. morphology detailed nanostructure different self-assemblies were revealed performing transmission electron microscopy (TEM), scanning (SEM), small-angle X-ray scattering (SAXS) measurements. TEM SAXS results indicated that microphase exhibited a lamellar structure an interlayer distance about 3 nm. was alternatively organized layers BPOSS POM according size dimension. polarity solvents substantially affected nanoassemblies but not aggregation POM. This research offers insights preparation nanomaterials micromorphologies simply adjusting solution components.

Language: Английский

Citations

Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration DOI

Hongjian Zhang, Ziyi Zhao, Chengtie Wu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination

Language: Английский

Citations

Integrated implantable triboelectric charge collector for nerve repair DOI

Chenglong Cai,

Ting Wang, Yixin Zhang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111087 - 111087

Published: March 1, 2025

Language: Английский

Citations

Magnetic Field‐Assisted Conductive Nerve Guidance Conduit Enabling Peripheral Nerve Regeneration with Wireless Electrical Stimulation DOI

Shiheng Liu,

Lifang Zhu,

Ming‐Wei Chang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Nerve guidance conduits capable of wireless stimulation represent a promising approach for addressing peripheral nerve defects. However, traditional electrical methods are not sufficiently convenient and may cause secondary damage. In this study, conductive conduit combined with using alternating magnetic fields is presented. The coated nanographene incorporated Fe 3 O 4 nanoparticles induces currents creates supportive microenvironment enhancing regeneration. Finite element analysis confirms that the generates electromotive force under an external field. exhibits improved morphology, physicochemical properties, conductivity by six orders magnitude. vitro experiments demonstrate promotes Schwann cell proliferation, migration, intercellular communication through microcurrents, as well neuronal axon extension. TEM images confirm extension myelin sheath thickness, indicating its high efficiency in promoting regeneration across vivo studies show generated microcurrent electromagnetic stimulation, significantly restoration, gastrocnemius muscle regeneration, motor function recovery, tissue growth, achieving results comparable to gold‐standard autograft method. Overall, work highlights effectiveness induction repair presents new, non‐invasive

Language: Английский

Citations

Progressive Microneedles For Targeting And Intelligent Drug Delivery DOI

Jiaqi Li,

Qing Xia, Shuwen Ma

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101051 - 101051

Published: March 1, 2025

Language: Английский

Citations