Navigating the Brain: Harnessing Endogenous Cellular Hitchhiking for Targeting Neoplastic and Neuroinflammatory Diseases

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101040 - 101040

Published: Feb. 1, 2025

Language: Английский

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Recent Treatment Strategies and Molecular Pathways in Resistance Mechanisms of Antiangiogenic Therapies in Glioblastoma

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2975 - 2975

Published: Aug. 27, 2024

Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.

Language: Английский

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Exosomes in the Chemoresistance of Glioma: Key Point in Chemoresistance

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(4)

Published: Feb. 1, 2025

ABSTRACT Gliomas are the most ordinary primary virulent brain tumours and commonly used clinical treatments include tumour resection, radiation therapy chemotherapy. Although significant progress has been made in recent years progression‐free survival (PFS) overall (OS) for patients with high‐grade gliomas, prognosis remains poor. Chemoresistance refers to phenomenon of decreased sensitivity cells drugs, resulting reduced or ineffective drug efficacy, is an important cause failure Exosomes, a type extracellular vesicle, secreted by cancer various stromal microenvironment (TME) transfer their inclusions cells, increasing chemoresistance. Furthermore, depletion exosomes reverses certain detrimental effects on metabolism restores chemotherapeutic agents. Here, we summarised correlation between resistance agents glioma patients, mechanisms action involved value. We aimed afford new thoughts research, diagnosis intervention chemoresistance patients.

Language: Английский

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The potential of exosomes as a new therapeutic strategy for glioblastoma

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 203, P. 114460 - 114460

Published: Aug. 31, 2024

Glioblastoma (GBM) stands for the most common and aggressive type of brain tumour in adults. It is highly invasive, which explains its short rate survival. Little known about risk factors, current therapy still ineffective. Hence, efforts are underway to develop novel effective treatment approaches against this cancer. Exosomes being explored as a promising strategy conveying delivering therapeutic cargo GBM cells. They can fuse with cell membrane and, consequently, serve delivery systems context. Due their nanoscale size, exosomes cross blood-brain barrier (BBB), constitutes significant hurdle chemotherapeutic drugs used GBM. subsequently inhibit oncogenes, activate suppressor genes, induce immune responses, control growth. However, despite representing tool GBM, further research clinical studies regarding exosome biology, engineering, applications need be completed. Here, we sought review application through an in-depth analysis scientific on entire process, from isolation purification design transformation into anti-oncogenic drug systems. Surface modification enhance BBB penetration GBM-cell targeting also topic discussion.

Language: Английский

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Hierarchically Engineered Self-Adaptive Nanoplatform Guided Intuitive and Precision Interventions for Deep-Seated Glioblastoma

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Glioblastoma multiforme (GBM), particularly the deep-seated tumor where surgical removal is not feasible, poses great challenges for clinical treatments due to complicated biological barriers and risk of damaging healthy brain tissue. Here, we hierarchically engineer a self-adaptive nanoplatform (SAN) that overcomes delivery by dynamically adjusting its structure, surface charge, particle size, targeting moieties precisely distinguish between parenchyma cells. We further devise

Language: Английский

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Core-Shell Hybrid Liposomes: Transforming Imaging Diagnostics and Therapeutic Strategies

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114597 - 114597

Published: Feb. 1, 2025

Language: Английский

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Polypeptide nanomicelles co-deliver PLK1 and BCL-2/xL inhibitors for synergetic therapy of brain tumor

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102712 - 102712

Published: March 10, 2025

Language: Английский

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Hierarchical Targeting Nanoplatform for NIR‐II Photoacoustic Imaging and Photo‐Activated Synergistic Immunotherapy of Glioblastoma

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Glioblastoma (GBM) stands as the most aggressive malignant brain tumor, characterized by poor prognosis, high recurrence rate, and resistance to multiple therapies, posing a significant clinical challenge. Here, hierarchical targeting platform is presented for NIR‐II photoacoustic (PA) imaging‐guided photo‐chemo synergistic immunotherapy of GBM. A new molecular probe developed with exceptional light‐harvesting capabilities enhanced motion, boosting both photothermal conversion PA signal. This probe, combined thermo‐responsive prodrug, assembled into nanoparticles that are further camouflaged tumor cell membranes bioorthogonally modified transferrin‐mimicking peptide, facilitating blood‐brain barrier penetration GBM targeting. High‐contrast imaging allows precise detection delineation GBM, providing accurate guidance subsequent treatment. The light‐triggered effect, coupled hyperthermia‐activated significantly induces immunogenic death, enhancing tumor‐killing efficiency amplifying anti‐tumor immune response. self‐synergistic not only stimulates robust immunity inhibits primary growth but also prevents post‐surgical recurrence, prolonging survival time. work exemplifies novel paradigm tackling diagnostic therapeutic challenges posed deeply seated poorly tumors.

Language: Английский

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A switch-on chemo-photothermal nanotherapy impairs glioblastoma

Materials Horizons, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Judiciously combined modality approaches have proved highly effective for treating most forms of cancer, including glioblastoma. Created in BioRender. Mendes, M. (2025) https://BioRender.com/z98a881.

Language: Английский

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Effects of Asiatic acid on brain cancer by altering astrocytes and the AKT1-PRKCB signaling pathway: A genomic and network pharmacology perspective

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149652 - 149652

Published: April 1, 2025

Language: Английский

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