Hydrogen-Bonded Organic Framework Nanosheets with Rich Free Oxygen Atoms for NO₂ Sensing

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Hydrogen-bonded organic frameworks (HOFs) are under fast development in broad applications but have not been well explored for chemiresistive gas sensing yet primarily due to insufficient active sites. Herein, a new porphyrin-based HOF-199 is constructed by OH···O hydrogen bonds featuring layered networks and rich free oxygen (O) atoms, which further exfoliated into few-layer nonosheets with more dangling O sites through an ultrasound-assisted liquid exfoliation method (namely L-HOF-199). Benefiting from electron-donor sites, L-HOF-199 demonstrates exceptional NO2 properties ambient conditions, achieving remarkable 3.25-fold improvement sensitivity (152% toward 5 ppm of NO2) faster response speed (52 s), relative HOF-199. This work provides promising platform the rational design advanced sensors via functional HOF chemistry.

Language: Английский

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Self-Assembled Protein–Polymer Nanoparticles via Photoinitiated Polymerization-Induced Self-Assembly for Targeted and Enhanced Drug Delivery in Cancer Therapy

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 856 - 856

Published: Feb. 13, 2025

Protein-polymer bioconjugates offer numerous advantages in biomedical applications by integrating the benefits of functional proteins and tunable synthetic polymers. Developing drug-loaded protein-polymer nanoparticles, with a receptor-targeting protein forming nanoparticle shell, would be ideal for targeted delivery drugs to cancer cells that overexpress specific receptors more effective therapy. In this study, we report synthesis reduction-responsive nanoparticles photoinitiated polymerization-induced self-assembly (photo-PISA) approach. Anti-cancer can efficiently encapsulated at high concentrations within during photo-PISA process. These present transferrin (Tf) on their surfaces, capable targeting overexpressed Tf found cells. It was demonstrate enhanced cellular uptake anti-cancer drug, curcumin, via receptor-mediated endocytosis, compared control PEGylated lack capability. Moreover, release curcumin response reducing environment, characteristic health Consequently, synthesized are inducing cell death demonstrating potential as an drug system

Language: Английский

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Water‐Dispersible MXene Governs Glycolysis for Cancer Synergistic Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Targeted delivery of glucose oxidase (GOx) using MXene remains a great challenge due to its poor dispersion and susceptibility oxidation, the hypoxia high glutathione (GSH) contents make situation even more worrying. Herein, bovine serum albumin‐mediated non‐chemical modification strategy is developed, endowing titanium carbide with long‐time water‐dispersion further integrating it as glycolysis‐controllable therapy system without any chemotherapeutic agents. The also constructs an effective O 2 cycling GSH degradation pathway, which fundamentally adjusts tumor microenvironment greatly elevates both in vivo vitro effects. Reactive oxygen species are generated disrupt balance oxidative stress. Moreover, reduced efficiency mitochondrial energy production significantly inhibits level glycolysis hinders supply. study presents cancer treatment combining starvation/photothermal therapy, has superior anti‐cancer effects dual reducing levels diminishing cellular capacity.

Language: Английский

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Lanthanide-Doped Nanoparticles Anchoring on Metal–Organic Frameworks with Thermally Enhanced Upconversion Luminescence for Sensitive Nanothermometers

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58920 - 58930

Published: Oct. 17, 2024

Nanothermometers can detect changes in the local temperature living cells and vivo, revealing fundamental biological properties. Despite exploration of different temperature-responsive materials, design development temperature-sensing probes with high brightness sensitivity remain a daunting challenge. Here, we employed UiO-66 type metal-organic frameworks (MOFs) to anchor UNCPs on surface MOFs for constructing MOF@UCNPs nanohybrids. The situ composite method leads coordination interaction between ligands UCNPs, enabling controlled formation UCNPs. Remarkably, favors anomalous thermo-enhanced luminescence, achieving 35-fold enhancement UiO-66@NaYF4:Yb/Tm at 413 K. Furthermore, these nanohybrids luminescence are developed as multifunctional bioimaging intracellular sensing, demonstrating thermal 1.92% K-1 physiological range. Based findings, monitoring position was successfully carried out by designed nanoprobes vivo. These findings underscore potential nanohybrids, opening up new avenues platform analysis.

Language: Английский

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Zinc-based metal–organic frameworks as efficient carriers in combination therapy for hepatocellular carcinoma treatment

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: 174, P. 113921 - 113921

Published: Jan. 10, 2025

Language: Английский

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TiN Boosting the Oxygen Reduction Performance of Fe–N–C through the Relay-Catalyzing Mechanism for Metal–Air Batteries

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Metal–air batteries desire highly active, durable, and low-cost oxygen reduction catalysts to replace expensive platinum (Pt). The Fe–N–C catalyst is recognized as the most promising candidate for Pt; however, its durability hindered by carbon corrosion, while activity restricted due limited reaction. Herein, TiN creatively designed be hybridized with (TiN/Fe–N–C) relieve corrosion absorb more when catalyzing reduction. half-wave potential of TiN/Fe–N–C 0.915 V vs reverse hydrogen electrode 15 mV lost after 30,000 cycles accelerated test, higher than 0.893 26 Pt/C. solid zinc–air battery achieves a peak power density 238 mW/cm2, 2100 cycle stability at 30 °C, long-term 1100 h under −20 superior 150 mW/cm2 500 (−20 °C) Both calculations experiments indicate that has dual functions which not only relay abundant reaction but also strengthen adsorption force intermediates reaction, thus, enhancing Fe–N–C. Therefore, proposed catalytic strategy offers an efficient energy conversion devices.

Language: Английский

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Rigid rhombus Al(bpdc) metal-organic framework for efficient and reversible ammonia adsorption: Synthesis, performance and mechanism

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 131860 - 131860

Published: Jan. 1, 2025

Language: Английский

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Preparation, Coating, and Multimodal Therapeutic Properties of an Anticancer System Based on UiO-66(Ce)

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: 64(6), P. 2809 - 2814

Published: Jan. 31, 2025

UiO-66(Ce) was prepared from cerium metal, which could trigger Fenton-like reactions. A system DOX@UiO-66(Ce)@TA-Fe constructed by coating a metal polyphenol layer (TA-Fe) on the surface of DOX@UiO-66(Ce), loaded with anticancer drug doxorubicin hydrochloride (DOX). It produce reactive oxygen species to realize chemodynamic therapy and show stimuli-responsive release behaviors chemotherapy. In addition, displayed biocompatibility normal cells (L929 cells) toxicity cancer (MCF-7 cells), implying an ideal effect for multimodal therapy.

Language: Английский

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Core‐Shell Structure‐Based Smart Hydrogel Wound Dressing with Endogenous and Exogenous Dual Adhesion Dynamic Response to Promote Wound Healing

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract Herein, MIL‐88b‐NH 2 nanocage is designed with adenine inside the cage and tannins as gating outside cage. Based on this core‐shell structure, polyvinyl alcohol/carboxymethyl chitosan/MIL/adenine/tannic acid (PCMAT) hydrogels are able to respond endogenously exogenously at different stages of wound healing. The engineered hydrogel have tunable adhesion intelligence. optimal PCMAT‐0.3 reduced pore size ≈13.5 µm under endogenous response conditions, antimicrobial performance reached more than 80% within 6 h. Tensile strength strain break by 8.47% 60.52% respectively exogenous conditions. Evaluation healing effect mouse back tissue shows that rate significantly better control group without incorporation day 14. It provides an idea for development smart dressing integrates multifunctionality.

Language: Английский

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A Multifunctional Fe‐Based Metal–Organic Framework With Ferroptosis for Synergistic Therapy

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 8, 2025

ABSTRACT Generally, single cancer treatment is insufficient to achieve ideal therapeutic effect. Multimodal therapy has the potential overcome efficacy challenges and reveals great promise in enhancing Herein, a combination system (DOX@Fe‐PBC) based on chemotherapy, chemodynamic (CDT), ferroptosis was constructed by loading anticancer drug doxorubicin hydrochloride (DOX) into Fe‐based metal–organic framework (Fe‐PBC). In simulated tumor microenvironment, released DOX be DNA intercalator topoisomerase II inhibitor realize chemotherapy (CT) iron ions were delivered induce Fenton reaction, which boost generation of •OH, resulting enhancement effect (CDT). Meantime, could consume glutathione (GSH) reduce expression peroxidase 4 (GPX4); then, lipid peroxides (LPO) accumulated ferroptosis. DOX@Fe‐PBC provided an effective strategy CDT, treatment.

Language: Английский

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