Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
Fungal
infections
pose
a
significant
global
public
health
threat,
particularly
candidemia
and
biofilm
formation.
Current
antifungal
drugs
have
limitations
due
to
their
toxicity
drug
resistance.
Ion
interference
therapy,
cuproptosis,
shows
potential
for
disease
treatment.
Herein,
nano
copper-chelate
Cu(DDC)2@BSA
(CDB)
is
synthesized
research
the
mechanism
of
cuproptosis-like
death
investigated.
Initially,
CDB
demonstrates
strong
inhibitory
effect
on
multiple
fungi
exhibits
activity
against
two
fluconazole-resistant
clinical
isolates.
The
decrease
in
ATPase
mitochondrial
membrane
indicates
that
may
involve
dysfunction.
Subsequently,
transcriptome
analysis
reveals
alterations
genes
related
copper
ions
transport
regulation,
oxidative
phosphorylation,
function.
Additionally,
overload
observed,
along
with
an
increase
heat
shock
protein
70
levels
lipoic
acid
synthetase
expression.
Given
biofilms
hinder
penetration,
quaternary
ammonium
chitosan
microneedles
are
employed
combination
penetrate
barrier
enhance
effect.
Overall,
this
study
provides
new
insight
into
presents
promising
strategy
fungal
infection
treatment
through
microneedle
delivery
system.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Abstract
Bacterial
infections
are
a
significant
obstacle
to
the
healing
of
acute
and
chronic
wounds,
such
as
diabetic
ulcers
burn
injuries.
Traditional
antibiotics
primary
treatment
for
bacterial
infections,
but
they
present
issues
antibiotic
resistance,
limited
efficacy,
potential
side
effects.
This
challenge
leads
exploration
nanozymes
alternative
therapeutic
agents.
Nanozymes
nanomaterials
with
enzyme‐like
activities.
Owing
their
low
production
costs,
high
stability,
scalability,
multifunctionality,
have
emerged
prominent
focus
in
antimicrobial
research.
Among
various
types
nanozymes,
metal‐based
offer
several
benefits,
including
broad‐spectrum
activity
robust
catalytic
properties.
Specifically,
copper‐based
(CuNZs)
shown
considerable
promoting
wound
healing.
They
exhibit
strong
effects,
reduce
inflammation,
enhance
tissue
regeneration,
making
them
highly
advantageous
use
care.
review
describes
dual
functions
CuNZs
combating
infection
facilitating
repair.
Recent
advancements
design
synthesis
CuNZs,
evaluating
promotion,
biosafety
both
vitro
vivo
on
basis
core
components,
critically
important.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Abstract
Extracellular
vesicles
(EVs)
are
heterogeneous
membrane-like
secreted
by
living
cells
that
involved
in
many
physiological
and
pathological
processes
act
as
intermediaries
of
intercellular
communication
molecular
transfer.
Recent
studies
have
shown
EVs
from
specific
sources
regulate
tissue
repair
regeneration
delivering
proteins,
lipids,
nucleic
acids
to
target
signaling
molecules.
Nanotechnology
breakthroughs
facilitated
the
development
exploration
engineered
for
repair.
Enhancements
through
gene
editing,
surface
modification,
content
modification
further
improved
their
therapeutic
efficacy.
This
review
summarizes
potential
regeneration,
mechanisms
action,
research
progress
regenerative
medicine.
highlights
design
logic
typical
examples
explores
prospects
The
aim
this
is
provide
new
insights
into
applications,
thereby
expanding
use
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 9, 2024
Bacterial
infection
and
an
excessive
inflammatory
response
are
two
major
factors
that
affect
the
healing
of
infected
wounds.
The
zinc
oxide/copper
sulfide
(ZnO-CuS)
microspheres
(MSs)
developed
in
this
work
can
kill
bacteria
resist
inflammation.
ZnO-CuS
exhibits
different
enzyme-like
activities
depending
on
pH.
In
acidic
environments,
peroxidase-like
(POD-like)
activity
convert
hydrogen
peroxide
(H
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 16, 2024
Abstract
Implant‐related
infections
are
characterized
by
the
formation
of
bacterial
biofilms.
Current
treatments
have
various
drawbacks.
Nanozymes
with
enzyme‐like
activity
can
produce
highly
toxic
substances
to
kill
bacteria
and
remove
biofilms
without
inducing
drug
resistance.
However,
it
is
difficult
for
current
monometallic
nanozymes
function
well
in
complex
biofilm
environments.
Therefore,
development
multimetallic
efficient
multienzyme
activities
crucial.
In
present
study,
bimetallic
nanozyme,
ZnO‐CuS
nanoflowers
peroxidase
(POD),
glutathione
oxidase
(GSH‐Px),
catalase
(CAT)
successfully
synthesized
via
calcination
loaded
into
F127
hydrogels
treatment
implant‐related
infections.
The
ability
bind
key
antimicrobial
activity.
addition,
H
2
O
disrupt
metabolism
MRSA
,
including
arginine
synthesis,
nucleotide
excision
repair,
energy
metabolism,
protein
synthesis.
ZnO‐CuS/F127
hydrogel
combination
has
been
demonstrated
be
effective
clearing
infection
facilitating
switch
M1
macrophages
M2‐repairative
phenotype
implant
mice.
Furthermore,
favorable
biosafety,
their
toxicity
negligible.
provided
a
promising
biomedical
strategy
healing
infections,
highlighting
potential
clinical
applications.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 21, 2025
Treatment
of
osteoarthritis
(OA)
remains
challenging
owing
to
its
complex
pathological
microenvironment,
which
involves
reactive
oxygen
species,
chronic
inflammation,
mitochondrial
dysfunction,
energy
deficiency,
and
cartilage
degeneration.
Herein,
we
report
for
extracellular
vesicles
(SP-EVs)
derived
from
the
photosynthetic
microorganism
Spirulina
platensis
contain
antioxidative
ATP-dependent
active
metabolic-related
compounds
OA
treatment.
SP-EVs
were
effectively
delivered
chondrocytes,
demonstrating
potential
modulating
cellular
communication
homeostasis.
To
facilitate
sustained
delivery
SP-EVs,
rhein
hydrogel
system
was
used
intra-articular
injection
(Rh
Gel@SP-EVs),
demonstrated
pH
responsiveness
under
mildly
acidic
conditions
synergistic
anti-inflammatory
effects.
Rh
Gel@SP-EVs
significantly
rescued
dysfunction
by
ameliorating
inflammation-mediated
oxidative
stress
restoring
membrane
in
chondrocytes.
Improved
function
facilitates
replenishment
ATP
levels,
further
contributing
balance
anabolic
catabolic
processes
within
matrix,
eventually
decelerating
progression.
also
modulated
Janus
kinase-signal
transducer
activator
transcription
3
signaling
pathway,
implicated
suppressing
inflammatory
responses.
This
therapeutic
strategy
utilized
a
microalgae-based
herbal
modulate
release
offering
an
effective
approach
treating
regulating
metabolism
mechanisms.
