Nanomotors as Therapeutic Agents: Advancing Treatment Strategies for Inflammation‐Related Diseases DOI
Min Luo,

Fukun Zhao,

Yuanmin Wang

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Inflammation is a physiological response of the body to harmful stimuli such as pathogens, damaged cells, or irritants, involving series cellular and molecular events. It associated with various diseases including neurodegenerative disorders, cancer, atherosclerosis, leading cause global mortality. Key inflammatory factors, Tumor Necrosis Factor‐alpha (TNF‐α), Interleukin‐1 (IL‐1), Interleukin‐6 (IL‐6), Monocyte Chemoattractant Protein‐1 (MCP‐1/CCL2), RANTES (CCL5), prostaglandins, play central roles in inflammation disease progression. Traditional treatments NSAIDs, steroids, biologic agents, antioxidants have limitations. Recent advancements nanomaterials present promising solutions for treating inflammation‐related diseases. Unlike that rely on passive targeting face challenges precise drug delivery, nanomotors, driven by chemical optical stimuli, offer more dynamic approach actively navigating sites, thereby enhancing delivery efficiency therapeutic outcomes. Nanomotors allow controlled release specific environmental changes, pH ensuring effective concentrations at sites. This active capability enables use smaller doses, which reduces overall usage, costs, potential side effects compared traditional treatments. By improving precision efficiency, nanomotors address limitations conventional therapies represent significant advancement treatment review summarizes latest research nanomotor‐mediated discusses future directions optimizing their clinical translation.

Language: Английский

Nano-/Microrobots for Environmental Remediation in the Eyes of Nanoarchitectonics: DOI Creative Commons
Anna Jančík Procházková, Katsuhiko Ariga

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Nano-/microrobots have been demonstrated as an efficient solution for environmental remediation. Their strength lies in their propulsion abilities that allow active “on-the-fly” operation, such pollutant detection, capture, transport, degradation, and disruption. Another advantage is versatility, which allows the engineering of highly functional solutions a specific application. However, latter can bring complexity to applications; versatility dimensionality, morphology, materials, surface decorations, other modifications has crucial effect on resulting abilities, compatibility with environment, overall functionality. Synergy between decorations its projection functionality object nanoarchitectonics. Here, we scrutinize nano-/microrobots eyes nanoarchitectonics: list general concepts help assess synergy limitations individual procedures fabrication processes operation at macroscale. The nanoarchitectonics approached from microscopic level, focusing dimensionality through nanoscopic evaluating influence decoration nanoparticles quantum dots, moving molecular single-atomic level very fine tuning presented review aims lay provide overview advanced nano-/microrobot remediation beyond.

Language: Английский

Citations

2
Penetration enhanced nanomedicine through hypoxia regulated ligand-controllable shielding DOI

Sumeng Qian,

Zhendong Ren,

Sisi Ma

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 105, P. 106604 - 106604

Published: Jan. 5, 2025

Language: Английский

Citations

1
Dual functional nanoplatforms potentiate osteosarcoma immunotherapy via microenvironment modulation DOI Creative Commons
Shunyi Lu, Yuqi Yang,

Zhuorun Song

et al.

National Science Review, Journal Year: 2025, Volume and Issue: 12(3)

Published: Jan. 10, 2025

Osteosarcoma (OS), a highly aggressive bone tumor, presents significant challenges in terms of effective treatment. We identified that cellular autophagy was impaired within OS by comparing clinical samples through bioinformatic analyses and further validated the inhibition mitochondrial at transcriptomic level. Based on this finding, we investigated therapeutic potential dual functional metal nanoplatform (MnSx) to facilitate transition from protective effect low-level killing high-level OS. MnSx facilitated intracellular H2S generation via endocytosis, leading S-sulfhydration ubiquitin-specific peptidase 8 (USP8) subsequent promotion vitro. Additionally, activated cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator interferon genes (STING) pathway, enhancing autophagic response accelerating tumor cell death. Moreover, it demonstrated vivo MnSx, one hand, mediated activation USP8 H2S, while Mn2+ promoted maturation dendritic cells, cytotoxic T lymphocytes contributed eradication. Such could be suppressed inhibitor chloroquine. Importantly, synergistic combination therapy with immune checkpoint inhibitors showed promise for achieving complete remission This study highlights as dual-functional platform treatment offers novel directions future research field.

Language: Английский

Citations

1
Endogenous Protein‐Modified Gold Nanorods as Immune‐Inert Biomodulators for Tumor‐Specific Imaging and Therapy DOI Creative Commons
Chunyan Fang, Yueming Cai,

He Cui

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract Engineered modifications of nanomaterials inspired by nature hold great promise for disease‐specific imaging and therapies. However, conventional polyethylene glycol modification is limited immune system rejection. The manipulation gold nanorods (Au NRs) modified endogenous proteins (eP@Au) reported as an engineered biomodulator enhanced breast tumor therapy. results show that eP@Au NRs neither activate inflammatory factors in vitro nor elicit rejection responses vivo. Tumor‐specific exhibit a dual‐modal capability trigger mild photothermal effect under near‐infrared light irradiation, enabling highly efficient therapy tumors. Transcriptome sequencing confirmatory experiments reveal the antitumor mainly attributed to repression PI3K‐Akt/MAPK signaling pathways at molecular level. This powerful surprising situ eP‐regulated biomodulation demonstrates advantages convenient fabrication, inert immunogenicity, biocompatibility, providing alternative strategy biomedical

Language: Английский

Citations

1
MOF-Derived Oxygen-Deficient Titania-Mediated Photodynamic/Photothermal-Enhanced Immunotherapy for Tumor Treatment DOI
Xin Jiang, Zhengjie Huang, Zhuqing Liu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(27), P. 34591 - 34606

Published: June 25, 2024

Immunotherapy has emerged as a revolutionizing therapeutic modality for cancer. However, its efficacy been largely limited by weak immune response and an immunosuppressive tumor microenvironment. Herein, we report metal–organic framework (MOF)-derived titanium oxide nanoparticle (MCTx NP) booster that can greatly improve the immunotherapy inducing "immunogenic cell death" (ICD) remodeling The NPs, inheriting characteristic structure of MIL-125 enriched with oxygen vacancies (OVs), demonstrate both high photothermal conversion efficiency reactive species (ROS) generation yield upon near-infrared (NIR) activation. Moreover, NPs release O2 reduce glutathione (GSH) in environment, showcasing their potential to reverse In vitro/vivo results MCTx directly kill cells effectively eliminate primary tumors exerting dual photodynamic/photothermal therapy under single NIR irritation. At same time, augment PD-L1 blockade potently ICDs reversing microenvironment, including promoting dendritic (DC) maturation, decreasing regulatory T (Tregs)' infiltration, increasing cytotoxic lymphocytes (CTLs) helper (Ths), resulting effective distant suppression. This work highlights NP-mediated photodynamic- photothermal-enhanced strategy treatment.

Language: Английский

Citations

4
Amorphous/Crystalline Urchin‐Like TiO2 SERS Platform for Selective Recognition and Efficient Identification of Glutathione DOI Open Access
Xiaoyu Song, Lei Xu, Li Li

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Glutathione serves as a common biomarkers in tumor diagnosis and treatment. The levels of its intracellular concentration permit detailed investigation the microenvironment. However, low polarization weak Raman scattering cross‐section make direct indirect detection challenging. This study designs an amorphous‐crystalline urchin‐like TiO 2 (AC‐UL‐TiO ) for accurate identification GSH GSSG. By synergistically regulating crystalline core amorphous shell, bandgap structure is optimized, thereby enhancing charge transfer efficiency. AC‐UL‐TiO demonstrates excellent SERS performance detecting dye molecules with good selectivity mixed analytes. enhancement factor (EF) R6G 6.89 × 10 6 , limit (LOD) −10 M. A SERS‐colorimetric dual‐modality platform developed based on @DTNB system to accurately monitor concentrations from 0 1000 µM, providing robust dual‐confirmation result. Importantly, combined principal component analysis method, can directly distinguish GSSG molecules. Besides, LOD are −8 M, which 100 times higher than that detection. These findings indicate holds potential trace microenvironments.

Language: Английский

Citations

0
FOF1-ATPase Biomolecular Motor: Structure, Motility Manipulations, and Biomedical Applications DOI
Xuhui Zhou, Miao Sun,

Xiu De Yang

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Biomolecular motors are dynamic systems found in organisms with high energy conversion efficiency. FOF1-ATPase is a rotary biomolecular motor known for its near 100% It utilizes the synthesis and hydrolysis of ATP to induce conformational changes proteins, thereby converting chemical into mechanical motion. Given their efficiency, autonomous propulsion capability, modifiable structures, have attracted significant attention potential biomedical applications. This Review aims introduce detailed structure FOF1-ATPase, explore various motility manipulation strategies, summarize applications biological detection cargo delivery. Additionally, innovative research methods proposed analyze motion mechanism more comprehensively, goal advancing Finally, this concludes key insights future perspectives.

Language: Английский

Citations

0
A novel Nitrogen-Doped Water-Soluble carbon dot for highly selective Recognition of Mg2+ by chelation conjugation enhancement effect (CCE) and its application in Synergistically enhanced photodynamic antibacterial DOI
Kezhen Zhang,

Xiaoyong Tian,

Peipei Xu

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112842 - 112842

Published: Jan. 1, 2025

Language: Английский

Citations

0
NIR-II Photoresponsive Antibacterial Coatings on Titanium Implants Using Strontium Titanate Metastructures DOI
Feiyang Hong, Honglian Wang, Xiaoyi Ma

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dual-Ligand Assisted Anisotropic Assembly for the Construction of NIR-II Light-Propelled Mesoporous Nanomotors DOI
Jia Jia, Runfeng Lin, Minchao Liu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

The advent of autonomous nanomotors presents exciting opportunities for nanodrug delivery. However, significant potential remains enhancing the asymmetry and advancing development second near-infrared (NIR-II) light-propelled capable operating within deep tissues. Herein, we developed a dual-ligand assisted anisotropic assembly strategy that enables precise regulation interfacial energy between selenium (Se) nanoparticle periodic mesoporous organosilica (PMO). This facilitates controllable growth PMO on Se nanoparticle, leading to formation Se&PMO Janus nanohybrids. exposure ratio subunit nanohybrids can be finely tuned from 0% 75%. Leveraging transformability subunit, variety functional MxSe&PMO nanocomposites (MxSe denotes metal selenide) were further derived. As proof concept, CuSe&PMO nanohybrids, with NIR-II photothermal properties, employed as light-driven nanomotors. By precisely controlling CuSe nanostructure, these achieved optimal self-propulsion, thus cellular uptake promoting tumor penetration. Furthermore, high loading capacity hydrophobic framework enabled incorporation disulfiram, thereby significantly boosting efficacy synergistic active-motion therapy.

Language: Английский

Citations

0