ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 19, 2025
Photocatalytic
micro/nanomotors
(MNMs)
driven
by
electrophoresis
have
attracted
considerable
attention
virtue
of
their
active
mobility
and
versatile
functionality.
However,
the
rapid
recombination
photogenerated
electron-hole
pairs
on
light
illumination
severely
compromises
involvement
charge
species
in
catalytic
redox
reactions
fuels,
thus
hindering
both
propulsion
application
performance
photocatalytic
MNMs.
Herein,
we
report
a
facile
strategy
to
amplify
separation
incorporating
liquid
metal
(LM)
into
construction
MNMs,
thereby
strengthening
electrophoretic
MNMs
promoting
generation
reactive
oxygen
(ROS)
for
antibacterial
application.
The
are
constructed
with
gallium
(Ga)
LM
core,
coated
abundant
graphite-phase
carbon
nitride
(g-C3N4)
nanosheets
half
covered
thin
platinum
layer.
These
exhibit
self-propulsion
hydrogen
peroxide
(H2O2)
solution,
motion
dynamics
further
enhanced
irradiation.
Theoretical
calculations
simulations
reveal
that
composition
between
Ga
g-C3N4
forms
an
ohmic
junction
electronic
energy
band
structure,
which
effectively
improves
efficiency
pairs.
results
align
well
experimental
electrochemical
tests
consequently
intensify
H2O2,
as
accelerate
migration
across
contributing
enhancement
performance.
Simultaneously,
amplified
electrons
facilitates
increased
ROS
generation,
empowering
motion-enhanced
activity
against
Escherichia
coli.
Finally,
vivo
wound
healing
experiment
is
conducted,
verifying
superior
therapeutic
This
work
not
only
provides
insights
role
phoretic
but
also
gives
inspiration
developing
advanced
biomedical
applications.
National Science Review,
Journal Year:
2025,
Volume and Issue:
12(3)
Published: Jan. 10, 2025
Osteosarcoma
(OS),
a
highly
aggressive
bone
tumor,
presents
significant
challenges
in
terms
of
effective
treatment.
We
identified
that
cellular
autophagy
was
impaired
within
OS
by
comparing
clinical
samples
through
bioinformatic
analyses
and
further
validated
the
inhibition
mitochondrial
at
transcriptomic
level.
Based
on
this
finding,
we
investigated
therapeutic
potential
dual
functional
metal
nanoplatform
(MnSx)
to
facilitate
transition
from
protective
effect
low-level
killing
high-level
OS.
MnSx
facilitated
intracellular
H2S
generation
via
endocytosis,
leading
S-sulfhydration
ubiquitin-specific
peptidase
8
(USP8)
subsequent
promotion
vitro.
Additionally,
activated
cyclic
guanosine
monophosphate-adenosine
monophosphate
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway,
enhancing
autophagic
response
accelerating
tumor
cell
death.
Moreover,
it
demonstrated
vivo
MnSx,
one
hand,
mediated
activation
USP8
H2S,
while
Mn2+
promoted
maturation
dendritic
cells,
cytotoxic
T
lymphocytes
contributed
eradication.
Such
could
be
suppressed
inhibitor
chloroquine.
Importantly,
synergistic
combination
therapy
with
immune
checkpoint
inhibitors
showed
promise
for
achieving
complete
remission
This
study
highlights
as
dual-functional
platform
treatment
offers
novel
directions
future
research
field.
Nano-/microrobots
have
been
demonstrated
as
an
efficient
solution
for
environmental
remediation.
Their
strength
lies
in
their
propulsion
abilities
that
allow
active
“on-the-fly”
operation,
such
pollutant
detection,
capture,
transport,
degradation,
and
disruption.
Another
advantage
is
versatility,
which
allows
the
engineering
of
highly
functional
solutions
a
specific
application.
However,
latter
can
bring
complexity
to
applications;
versatility
dimensionality,
morphology,
materials,
surface
decorations,
other
modifications
has
crucial
effect
on
resulting
abilities,
compatibility
with
environment,
overall
functionality.
Synergy
between
decorations
its
projection
functionality
object
nanoarchitectonics.
Here,
we
scrutinize
nano-/microrobots
eyes
nanoarchitectonics:
list
general
concepts
help
assess
synergy
limitations
individual
procedures
fabrication
processes
operation
at
macroscale.
The
nanoarchitectonics
approached
from
microscopic
level,
focusing
dimensionality
through
nanoscopic
evaluating
influence
decoration
nanoparticles
quantum
dots,
moving
molecular
single-atomic
level
very
fine
tuning
presented
review
aims
lay
provide
overview
advanced
nano-/microrobot
remediation
beyond.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Engineered
modifications
of
nanomaterials
inspired
by
nature
hold
great
promise
for
disease‐specific
imaging
and
therapies.
However,
conventional
polyethylene
glycol
modification
is
limited
immune
system
rejection.
The
manipulation
gold
nanorods
(Au
NRs)
modified
endogenous
proteins
(eP@Au)
reported
as
an
engineered
biomodulator
enhanced
breast
tumor
therapy.
results
show
that
eP@Au
NRs
neither
activate
inflammatory
factors
in
vitro
nor
elicit
rejection
responses
vivo.
Tumor‐specific
exhibit
a
dual‐modal
capability
trigger
mild
photothermal
effect
under
near‐infrared
light
irradiation,
enabling
highly
efficient
therapy
tumors.
Transcriptome
sequencing
confirmatory
experiments
reveal
the
antitumor
mainly
attributed
to
repression
PI3K‐Akt/MAPK
signaling
pathways
at
molecular
level.
This
powerful
surprising
situ
eP‐regulated
biomodulation
demonstrates
advantages
convenient
fabrication,
inert
immunogenicity,
biocompatibility,
providing
alternative
strategy
biomedical
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 12, 2024
Abstract
Proteins
have
emerged
as
promising
therapeutics
in
oncology
due
to
their
great
specificity.
Many
treatment
strategies
are
developed
based
on
protein
biologics,
such
immunotherapy,
starvation
therapy,
and
pro‐apoptosis
while
some
biologics
entered
the
clinics.
However,
clinical
translation
is
severely
impeded
by
instability,
short
circulation
time,
poor
transmembrane
transportation,
immunogenicity.
Micro‐
nano‐particles‐based
drug
delivery
platforms
designed
solve
those
problems
enhance
therapeutic
efficacy.
This
review
first
summarizes
different
types
of
proteins
research
stages,
highlighting
administration
limitations.
Next,
various
micro‐
nano‐particles
described
demonstrate
how
they
can
overcome
The
potential
then
explored
efficacy
combinational
therapies.
Finally,
challenges
future
directions
carriers
discussed
for
optimized
delivery.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(27), P. 34591 - 34606
Published: June 25, 2024
Immunotherapy
has
emerged
as
a
revolutionizing
therapeutic
modality
for
cancer.
However,
its
efficacy
been
largely
limited
by
weak
immune
response
and
an
immunosuppressive
tumor
microenvironment.
Herein,
we
report
metal–organic
framework
(MOF)-derived
titanium
oxide
nanoparticle
(MCTx
NP)
booster
that
can
greatly
improve
the
immunotherapy
inducing
"immunogenic
cell
death"
(ICD)
remodeling
The
NPs,
inheriting
characteristic
structure
of
MIL-125
enriched
with
oxygen
vacancies
(OVs),
demonstrate
both
high
photothermal
conversion
efficiency
reactive
species
(ROS)
generation
yield
upon
near-infrared
(NIR)
activation.
Moreover,
NPs
release
O2
reduce
glutathione
(GSH)
in
environment,
showcasing
their
potential
to
reverse
In
vitro/vivo
results
MCTx
directly
kill
cells
effectively
eliminate
primary
tumors
exerting
dual
photodynamic/photothermal
therapy
under
single
NIR
irritation.
At
same
time,
augment
PD-L1
blockade
potently
ICDs
reversing
microenvironment,
including
promoting
dendritic
(DC)
maturation,
decreasing
regulatory
T
(Tregs)'
infiltration,
increasing
cytotoxic
lymphocytes
(CTLs)
helper
(Ths),
resulting
effective
distant
suppression.
This
work
highlights
NP-mediated
photodynamic-
photothermal-enhanced
strategy
treatment.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Glutathione
serves
as
a
common
biomarkers
in
tumor
diagnosis
and
treatment.
The
levels
of
its
intracellular
concentration
permit
detailed
investigation
the
microenvironment.
However,
low
polarization
weak
Raman
scattering
cross‐section
make
direct
indirect
detection
challenging.
This
study
designs
an
amorphous‐crystalline
urchin‐like
TiO
2
(AC‐UL‐TiO
)
for
accurate
identification
GSH
GSSG.
By
synergistically
regulating
crystalline
core
amorphous
shell,
bandgap
structure
is
optimized,
thereby
enhancing
charge
transfer
efficiency.
AC‐UL‐TiO
demonstrates
excellent
SERS
performance
detecting
dye
molecules
with
good
selectivity
mixed
analytes.
enhancement
factor
(EF)
R6G
6.89
×
10
6
,
limit
(LOD)
−10
M.
A
SERS‐colorimetric
dual‐modality
platform
developed
based
on
@DTNB
system
to
accurately
monitor
concentrations
from
0
1000
µM,
providing
robust
dual‐confirmation
result.
Importantly,
combined
principal
component
analysis
method,
can
directly
distinguish
GSSG
molecules.
Besides,
LOD
are
−8
M,
which
100
times
higher
than
that
detection.
These
findings
indicate
holds
potential
trace
microenvironments.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 11, 2025
Biomolecular
motors
are
dynamic
systems
found
in
organisms
with
high
energy
conversion
efficiency.
FOF1-ATPase
is
a
rotary
biomolecular
motor
known
for
its
near
100%
It
utilizes
the
synthesis
and
hydrolysis
of
ATP
to
induce
conformational
changes
proteins,
thereby
converting
chemical
into
mechanical
motion.
Given
their
efficiency,
autonomous
propulsion
capability,
modifiable
structures,
have
attracted
significant
attention
potential
biomedical
applications.
This
Review
aims
introduce
detailed
structure
FOF1-ATPase,
explore
various
motility
manipulation
strategies,
summarize
applications
biological
detection
cargo
delivery.
Additionally,
innovative
research
methods
proposed
analyze
motion
mechanism
more
comprehensively,
goal
advancing
Finally,
this
concludes
key
insights
future
perspectives.
