Small,
Journal Year:
2025,
Volume and Issue:
21(9)
Published: Jan. 22, 2025
Abstract
Nanomaterials
with
unparalleled
physical
and
chemical
attributes
have
become
a
cornerstone
in
the
field
of
nanomedicine
delivery.
These
materials
can
be
engineered
into
various
functionalized
nanocarriers,
which
focus
research.
Stimulus‐responsive
nanodrug
delivery
systems
(SRDDS)
stand
out
as
sophisticated
class
nanocarriers
that
release
drugs
response
to
environmental
cues.
Due
complex
pathogenesis
multifaceted
pathological
environment
nervous
system,
developing
accurate
effective
drug
therapy
low
side‐effects
is
formidable
task.
In
recent
years,
SRDDS
been
widely
used
treatment
neurological
diseases.
By
customizing
align
specific
microenvironment
system
tissues
or
external
stimulation,
efficacy
enhanced.
This
review
provides
an
in‐depth
look
at
characteristics
diseases
highlights
case
studies
tailored
treat
these
disorders
based
on
unique
stimulation
criteria
triggers.
Additionally,
this
comprehensive
overview
progress
future
prospects
technology
diseases,
providing
valuable
guidance
for
its
transition
from
fundamental
research
clinical
application.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 22, 2025
Parkinson’s
disease
is
a
progressive
neurodegenerative
that
destroys
substantia
nigra
dopaminergic
neurons,
causing
tremors,
bradykinesia,
rigidity,
and
postural
instability.
Current
treatment
approaches
primarily
focus
on
symptom
management,
employing
pharmacological,
non-pharmacological,
surgical
methods.
However,
these
treatments
often
result
in
fluctuating
symptoms,
side
effects,
progression.
Here,
the
authors
have
reviewed
emerging
field
of
nanomedicine
as
promising
path
for
treatment,
emphasizing
its
potential
to
overcome
limitations
traditional
therapies.
Nanomedicine
utilizes
nanoparticles
targeted
drug
delivery,
leveraging
their
small
size
high
surface
area
volume
ratio
cross
blood-brain
barrier
deliver
therapeutic
agents
directly
affected
brain
regions.
Various
nanoparticles,
including
lipid-based,
polymeric,
metallic,
carbon-based,
shown
treatment.
Additionally,
nanocarrier
systems
like
liposomes,
nanogels,
dendrimers,
solid
lipid
offer
controlled
sustained
release
agents,
enhancing
bioavailability
reducing
effects.
This
review
provides
insights
into
pathophysiology
disease,
highlighting
mechanisms
neurodegeneration,
role
alpha-synuclein,
disruption
pathways.
It
further
discusses
application
gene
therapy
conjunction
with
interventions.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Extracellular
vesicles
(EVs)
are
critical
mediators
of
intercellular
communication,
carrying
bioactive
cargo
and
displaying
diverse
surface
components
that
reflect
their
cellular
origins
functions.
The
EV
surface,
composed
proteins,
lipids,
glycocalyx
elements,
plays
a
pivotal
role
in
targeting
recipient
cells,
mediating
biological
interactions,
enabling
selective
delivery.
This
review
comprehensively
examined
the
molecular
architecture
surfaces,
linking
biogenesis
to
functional
diversity,
highlights
therapeutic
diagnostic
potential
diseases
such
as
cancer
cardiovascular
disorders.
Additionally,
we
explore
emerging
applications
EVs,
including
machine-learning-assisted
analysis,
chemical
integration,
cross-system
combinations.
also
discusses
some
key
challenges
clinical
translation
EV-related
technologies.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13302 - 13302
Published: Dec. 11, 2024
This
review
aims
to
address
the
significant
challenges
of
treating
central
nervous
system
(CNS)
disorders
such
as
neurodegenerative
diseases,
strokes,
spinal
cord
injuries,
and
brain
tumors.
These
are
difficult
manage
due
complexity
disease
mechanisms
protective
blood–brain
barrier
(BBB),
which
restricts
drug
delivery.
Recent
advancements
in
nanoparticle
(NP)
technologies
offer
promising
solutions,
with
potential
applications
delivery,
neuroprotection,
neuroregeneration.
By
examining
current
research,
we
explore
how
NPs
can
cross
BBB,
deliver
medications
directly
targeted
CNS
regions,
enhance
both
diagnostics
treatment.
Key
NP
strategies,
passive
targeting,
receptor-mediated
transport,
stimuli-responsive
systems,
demonstrate
encouraging
results.
Studies
show
that
may
improve
minimize
side
effects,
increase
therapeutic
effectiveness
models
Alzheimer’s,
Parkinson’s,
stroke,
glioblastoma.
thus
represent
a
approach
for
disorder
management,
combining
delivery
diagnostic
capabilities
enable
more
precise
effective
treatments
could
significantly
benefit
patient
outcomes.
Chemical & Biomedical Imaging,
Journal Year:
2025,
Volume and Issue:
3(3), P. 137 - 168
Published: Feb. 2, 2025
Mesenchymal
stem-cell-derived
extracellular
vesicles
(MSC-EVs)
are
nanoscale
lipid
bilayer
secreted
by
mesenchymal
stem
cells.
They
inherit
the
parent
cell's
attributes,
facilitating
tissue
repair
and
regeneration,
promoting
angiogenesis,
modulating
immune
response,
while
offering
advantages
like
reduced
immunogenicity,
straightforward
administration,
enhanced
stability
for
long-term
storage.
These
characteristics
elevate
MSC-EVs
as
highly
promising
in
cell-free
therapy
with
notable
clinical
potential.
It
is
critical
to
delve
into
their
pharmacokinetics
thoroughly
elucidate
intracellular
vivo
trajectories.
A
detailed
summary
evaluation
of
existing
tracing
strategies
needed
establish
standardized
protocols.
Here,
we
have
summarized
anticipated
research
progress
various
biomedical
imaging
techniques,
including
fluorescence
imaging,
bioluminescence
nuclear
(PET,
SPECT),
tomographic
(CT,
MRI),
photoacoustic
imaging.
The
challenges
prospects
MSC-EV
strategies,
particular
emphasis
on
translation,
been
analyzed,
solutions
proposed.
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Extracellular
vesicles
have
been
deemed
as
potential
drug
carriers
for
treatment
of
various
diseases.
Recent
advances
summarized,
including
the
sources,
delivery
function,
extraction
and
cargo-loading
technology
extracellular
vesicles.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 9, 2025
Neurodegenerative
diseases
are
caused
by
the
progressive
degeneration
of
neurons
and/or
their
myelin
sheaths,
ultimately
leading
to
cognitive
and
motor
dysfunction.
Due
complex
pathogenesis
limited
efficacy
therapeutic
drugs,
these
have
attracted
significant
attention.
Achyranthes
aspera,
belongs
family
Amaranthaceae,
has
been
extensively
used
in
traditional
folk
medicines
for
treatment
various
ailments.
Modern
research
revealed
that
aspera
possesses
pharmacological
effects,
including
cardiocerebrovascular
protection,
immune
regulation,
antioxidation,
anti-aging.
Furthermore,
neuroprotective
effects
confirmed
numerous
scientific
studies.
This
review
focuses
on
primary
mechanisms
prevention
neurodegenerative
diseases,
as
well
potential
application
prospects.
aims
provide
insights
into
clinical
applications
directions
diseases.
