Inorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 14, 2025
The
accurate
monitoring
of
gallic
acid
(GA)
in
foodstuffs
is
crucial
for
safeguarding
human
health.
application
nanozymes
colorimetric
assays
offers
a
promising
route
assessing
the
GA
level.
However,
development
high-efficiency
and
cost-effective
quick
detection
holds
substantial
challenge.
In
this
study,
copper
(Cu)
nanoparticles
(NPs)
immobilized
on
N-doped
carbon
nanotubes
(NCNTs)
have
been
prepared,
exhibiting
exceptional
peroxidase
(POD)-like
activity
food.
anchoring
Cu
with
NCNTs
enables
their
excellent
antioxidant
capacity.
Then,
obtained
NPs/NCNTs
show
remarkable
POD-like
catalyzing
TMB
oxidation,
attributes
long-term
storage
stability
reproducibility.
Electrochemical
radical
scavenging
experiments
reveal
dual
mechanism
action
(involving
reactive
oxygen
species
electron
transfer)
POD-mimicking
activity.
Furthermore,
developed
catalytic
platform
applied
to
detect
actual
tea
samples,
demonstrating
high
reliability
potential
utility
food
industry.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
The
catalytic
activity
of
carbon
dots
(CDs)
has
generated
significant
interest
regarding
their
potential
applications
within
the
biomedical
field.
However,
structure‐activity
relationship
CDs
and
pharmacological
mechanisms
in
disease
treatment
have
yet
to
be
comprehensively
elucidated.
In
this
study,
two
distinct
types
exhibiting
superoxide
dismutase
(SOD)‐like
enzymatic
activities
are
synthesized
through
hydrothermal
(Hy‐CDs)
carbonization
(Ca‐CDs)
methods,
utilizing
Honeysuckle
as
common
material
precursor.
Through
comparative
analysis,
surface
group
modifications,
theoretical
calculations,
it
is
determined
that
SOD‐like
primarily
originated
from
stabilizing
influence
amino
on
(•O
2
−
)
intermediate
its
conjugation
π‐system,
facilitating
electron
transfer.
vitro
experiments
demonstrated
Hy‐CDs
effectively
alleviated
cellular
oxidative
stress
inhibited
secretion
pro‐inflammatory
cytokines.
Furthermore,
bioactivity
properties
contribute
pronounced
therapeutic
efficacy
acute
lung
injury
(ALI)
ischemia/reperfusion
(LIRI).
Guided
by
transcriptomic
analysis
Western
blotting,
inhibit
Caspase11/GSDMD‐dependent
non‐classical
pyroptosis
down‐regulating
GBP2
protein
expression,
thereby
contributing
inflammation.
This
study
elucidates
underlying
biological
applications.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
Periodontitis
is
a
chronic
inflammatory
condition
driven
by
plaque-associated
microorganisms,
where
uncontrolled
bacterial
invasion
and
proliferation
impair
host
immune
responses,
leading
to
localized
periodontal
tissue
inflammation
bone
destruction.
Conventional
therapies
face
challenges,
including
incomplete
microbial
clearance
the
rise
of
antibiotic
resistance,
limiting
their
precision
effectiveness
in
managing
periodontitis.
Recently,
nanotherapies
based
on
polymeric
materials
have
introduced
advanced
approaches
antimicrobial
therapy
through
diverse
mechanisms.
This
review
explored
specific
mechanisms,
emphasizing
design
polymer-based
agents
that
employ
individual
or
synergistic
actions,
evaluated
innovations
limitations
current
strategies
while
forecasting
future
trends
development
for
How
to
accurately
diagnose
and
treat
bacterial
infections
in
vivo
remains
a
huge
challenge.
Therefore,
we
have
developed
targeted
delivery
nanosystem
by
coextruding
the
pretreated
macrophage
membrane
of
S.
aureus
with
carbon
dots
(M@CD).
The
M@CD
demonstrates
potent
antibacterial
effects
both
vitro
through
generation
reactive
oxygen
species
(ROS).
Furthermore,
exhibits
enhanced
targeting
ability
stable
fluorescence
properties,
addressing
issues
such
as
poor
efficiency
high
immunogenicity
vivo.
This
innovative
approach
enables
infection
site
specific
aggregation
elimination
infections,
thereby
providing
promising
strategy
for
integrated
diagnosis,
treatment,
monitoring
infections.
Theranostics,
Journal Year:
2025,
Volume and Issue:
15(8), P. 3474 - 3489
Published: Feb. 24, 2025
Background:
Diabetic
wounds
infected
with
methicillin-resistant
Staphylococcus
aureus
(MRSA)
are
challenging
to
heal
due
biofilm
formation,
which
impairs
conventional
antibiotics
limited
penetration
and
severe
side
effects.
Near-infrared
(NIR)-driven
nanomotors
autonomous
motion
photothermal
effects
show
promise
for
antibacterial
therapy
but
often
lack
targeted
specificity.
Lysostaphin
(Ly),
an
enzyme
targeting
bacterial
cell
walls,
offers
excellent
potential
against
drug-resistant
MRSA.
Methods:
A
novel
NIR-driven
CSIL
nanomotor
has
fabricated
by
co-loading
indocyanine
green
(ICG)
lysostaphin
onto
spinous
yolk-shell
structured
C/SiO2@C
nanoparticles.
The
motion,
penetration,
efficacy
of
evaluated
in
vitro,
while
their
eradication
wound
healing
performance
assessed
MRSA-infected
diabetic
mouse
model
using
a
cascade
photodynamic
(CPDT)
strategy.
Results:
exhibit
properties
MRSA-targeting
They
can
effectively
eradicate
MRSA
biofilms
both
vitro
vivo,
suppress
virulence
biofilm-related
genes,
thus
promoting
shaping
microenvironment
dominated
M2
macrophages.
CPDT
strategy
is
able
avoid
excessive
ROS
production
thermal
damage,
enabling
safe
effective
therapy.
Conclusion:
nanomotors,
integrated
photothermal,
photodynamic,
properties,
represent
novel,
efficient
approach
wounds,
offering
significant
advantages
over
antibiotics.
The Analyst,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Carbon
dots
(CDs)
are
a
type
of
carbon-based
nanoparticle
(NP)
that
have
risen
in
popularity
due
to
their
unique
tuneable
physicochemical
and
optical
properties.
