Immune-related biomarkers in the neuromyelitis optica spectrum disorder; pathogenesis and therapeutic approaches DOI

Jingyong Li,

Yoshiyuki Dan,

Wei Su

et al.

Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110395 - 110395

Published: April 1, 2025

Language: Английский

Inorganic Nanoparticles and Blood-Brain Barrier Modulation: Advancing Targeted Neurological Therapies DOI
Zahra Razavi, F. S. Razavi,

Seyed Sina Alizadeh

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117357 - 117357

Published: Feb. 5, 2025

Language: Английский

Citations

7
Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives DOI Creative Commons
Virendra Kumar Yadav, Seshathiri Dhanasekaran, Nisha Choudhary

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.

Language: Английский

Citations

6
Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology DOI Creative Commons

Rupal Dhariwal,

Mukul Jain, Y. Mir

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as promising approach to enhance drug delivery across physiological barriers, particularly blood–brain barrier (BBB) blood-cerebrospinal fluid (B-CSFB). By employing nanoparticles, this research aims address critical challenges in diagnosis treatment conditions such Alzheimer’s, Parkinson’s, Huntington’s diseases. The multifactorial nature these disorders necessitates innovative solutions that leverage nanomedicine improve solubility, circulation time, targeted while minimizing off-target effects. findings underscore importance advancing applications develop effective therapeutic strategies can alleviate burden neurodegenerative diseases on individuals healthcare systems.

Language: Английский

Citations

2
Therapeutic modulation of mitochondrial dynamics by agmatine in neurodegenerative disorders DOI

Dhanshree Nibrad,

Amit Shiwal,

Manasi Tadas

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

Citations

2
Auramine O, food dye induces cognitive impairment, anxiety, alters synaptic transmission and neural growth in zebrafish model DOI

Karthikeyan Ramamurthy,

Santhanam Sanjai Dharshan,

Ashok Kumar

et al.

Journal of Environmental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging DOI
Saurabh Gupta, Muhammad Afzal, Neetu Agrawal

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 26, 2025

Language: Английский

Citations

1
Supramolecular assembly of methylthiazole derivative with β-cyclodextrin for the improvement of anti-inflammation performances: Structural insights from NBO approach DOI
Rajaram Rajamohan, Samikannu Prabu,

Agilan Balupillai

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142058 - 142058

Published: March 1, 2025

Language: Английский

Citations

1
Application of Machine Learning (ML) approach in discovery of novel drug targets against Leishmania: A computational based approach DOI
Hayat Ali Shah, Sabina Yasmin, Mohammad Yousuf Ansari

et al.

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: 117, P. 108423 - 108423

Published: March 12, 2025

Language: Английский

Citations

1
Revolutionizing Neurological Therapies: The Role of 3D-Printed Microneedles in Precision Brain-Targeted Drug Delivery DOI
Bhupendra G. Prajapati,

Lujain F. Alzaghari,

Prawez Alam

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106818 - 106818

Published: March 1, 2025

Language: Английский

Citations

1