Next-Generation Probiotics Delivery: Innovations and Applications of Single-Cell Encapsulation DOI
Aijun Xie,

Mengge Gao,

Haishun Du

et al.

Current Opinion in Food Science, Journal Year: 2024, Volume and Issue: unknown, P. 101234 - 101234

Published: Nov. 1, 2024

Language: Английский

Combating cancer immunotherapy resistance: a nano‐medicine perspective DOI Creative Commons
Xiangyi Kong, Xintong Xie, Juan Wu

et al.

Cancer Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading resistance. Various functionalized nanoparticles (NPs), modified with cationic lipids, pH‐sensitive compounds, or photosensitizers, exhibit unique physicochemical properties facilitate targeted delivery therapeutic agents tumor microenvironment (TME). These NPs are engineered modify activity. The crucial signal transduction pathways by which counteract resistance outlined, including enhancing antigen presentation, boosting activation infiltration tumor‐specific cells, inducing immunogenic cell death, counteracting immunosuppressive conditions in TME. Additionally, review summarizes current clinical trials involving NP‐based immunotherapy. Ultimately, it highlights potential nanotechnology advance

Language: Английский

Citations

0
Extracellular vesicles as nature's nano carriers in cancer therapy: insights toward preclinical studies and clinical applications DOI Creative Commons
Xiaotong Wu,

Yuhua Meng,

Zhimeng Yao

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107751 - 107751

Published: May 1, 2025

Extracellular vesicles (EVs), which are secreted by various cell types, hold significant potential for cancer therapy. However, there several challenges and difficulties that limit their application in clinical settings. This review, integrates the work of our team recent advancements this research field, discusses EV-based treatment strategies to guide application. The following discussed: 1) leveraging inherent properties EVs development treatments; 2) modifying using EV engineering methods improve drug loading delivery; 3) targeting key molecules tumor-derived (TDE) synthesis inhibit production; 4) clearing TDEs from tumor microenvironment. Additionally, on basis into vaccines bispecific antibodies, review elaborates enhance antitumor immunity via modifications can ability stability progress AI technology targeted delivery drugs. Although limited enhancing abilities, provides an in-depth discussion prior studies. Finally, summarizes use therapy highlights need be addressed.

Language: Английский

Citations

0
A Smart All-in-one Strategy Based on Hybrid Bacteria with Targeting Drug Delivery and Spatiotemporal Drug Release to Boost the Synergistic Therapeutic Efficacy against TNBC DOI Creative Commons

Wei Yuan,

Xiaoli Jiang, Jiayang Qin

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101849 - 101849

Published: May 1, 2025

Language: Английский

Citations

0
The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication DOI Creative Commons
Xiaoming Zhang, Ye Wang,

E Qiyu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 16, 2025

Probiotics such as Lactobacillus and Bifidobacterium spp. have been shown to be critical for maintaining host homeostasis. In recent years, key compounds of postbiotics derived from probiotic metabolism cellular secretion identified their role in organ immunity regulating intestinal inflammation. particular, probiotic-derived extracellular vesicles (PEVs) can act postbiotics, almost the same functional activity probiotics. They also strong biocompatibility loading capacity carry exogenous or parental active molecules reach distal organs play roles. This provides a new direction understanding intrinsic microbiota-host communication mechanism. However, most current studies on PEVs are limited effects/benefits, specific physicochemical properties, composition, mechanisms homeostasis, possible threats remain explored. Here, we review summarize unique properties bioactivities mediating communication, elucidate limitations research potential application postbiotics.

Language: Английский

Citations

0
Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy DOI Creative Commons
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Abstract Immunotherapy represents a highly promising modality in cancer treatment, with substantial advancements therapeutic strategies. The primary challenge lies enhancing the efficacy of immunotherapy approaches. Here, novel cryo‐inactivated cells (CICC) derived magnetic micromotors (CICC@FeMnP) are reported for tumor synergistic immunotherapy. Through control, CICC@FeMnP can on‐demand target and accumulate at site. FeMnP induce ferroptosis then trigger immunogenic cell death cells. CICC containing whole antigen conduct vaccination effects. Together Mn 2+ ‐mediated cGAS‐STING pathway to stimulate immune response, anti‐tumor effects be achieved. Importantly, not only facilitate establishment collaborative network enhance effective tumoricidal immunity but also long‐lasting memory These results contribute inhibition progression, recurrence lung metastasis, thereby prolonging overall survival tumor‐bearing mice. This work underscores potential an engineered biohybrid micromotor system as alternative approach against tumors.

Language: Английский

Citations

0
Surface-Functionalized Bacteria: Frontier Explorations in Next-Generation Live Biotherapeutics DOI
Jianqing Jiang, Fanhui Kong, Qi Lei

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123029 - 123029

Published: Dec. 15, 2024

Language: Английский

Citations

3
Tumor‐Targeted Catalytic Immunotherapy DOI Open Access

En‐Li Yang,

Wuyin Wang, Yingqi Liu

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting by modulating immunosuppressive tumor microenvironment (TME) through precise biochemical reactions. Achieving optimal targeting precision and therapeutic efficacy necessitates thorough understanding of properties underlying mechanisms tumor-targeted materials. This review provides comprehensive systematic overview recent advancements their critical role enhancing immunotherapy. It highlights types reactions, construction strategies materials, fundamental targeting, including passive, bioactive, stimuli-responsive, biomimetic approaches. Furthermore, outlines various tumor-specific strategies, encompassing tissue, cell, exogenous TME-responsive, cellular TME strategies. Finally, discussion addresses challenges future perspectives transitioning into clinical applications, offering insights that pave way next-generation therapies provide substantial benefits to patients settings.

Language: Английский

Citations

1
Next-Generation Probiotics Delivery: Innovations and Applications of Single-Cell Encapsulation DOI
Aijun Xie,

Mengge Gao,

Haishun Du

et al.

Current Opinion in Food Science, Journal Year: 2024, Volume and Issue: unknown, P. 101234 - 101234

Published: Nov. 1, 2024

Language: Английский

Citations

0