Cited by Research progress and prospect of tumor nanovaccine combination therapy strategy

Advances in Polymer‐Based Self‐Adjuvanted Nanovaccines DOI

Xiaoli Ling,

Ziyan Dong,

Jiao He

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Nanovaccines, as a new generation of vaccines, have garnered significant interest due to their exceptional potential in enhancing disease prevention and treatment. Their unique features, such high stability, antigens protection, prolonged retention, targeted delivery lymph nodes, immune cells, tumors, set them apart promising candidates the field immunotherapy. Polymers, with superior degradability, capacity mimic pathogen characteristics, surface functionality that facilitates modifications, serve ideal carriers for vaccine components. Polymer‐based self‐adjuvanted nanovaccines remarkable ability augment responses. The inherent adjuvant‐like properties polymers themselves offer pathway toward more efficient exploitation nanomaterials optimization nanovaccines. This review article aims summarize categorization elucidate mechanisms action adjuvants. Additionally, it delves into advantages limitations polymer‐based management prevention, providing valuable insights design application. comprehensive analysis could contribute development effective tailored wide range diseases.

Language: Английский

Citations

Cold Exposure Therapy Enhances Single-Atom Nanozyme-Mediated Cancer Vaccine Therapy DOI

Jinjun Ye, Hongwei Wang,

Jingzhi Zheng

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Single-atom nanozymes are highly effective in the preparation of tumor vaccines (TV) due to their superior peroxidase (POD) activity and excellent biocompatibility. However, immunosuppressive environment within tumors can diminish efficacy these vaccines. Cold exposure (CE) therapy, a noninvasive straightforward antitumor method, not only suppresses metabolism but also ameliorates milieu. In this study, we developed personalized TV using copper single-atom nanozyme (Cu SAZ) enhanced long-term by introducing CE. We initially synthesized Cu SAZ via high-temperature carbonization, which demonstrated robust POD photothermal characteristics. Upon 808 nm laser irradiation, generated reactive oxygen species (ROS) heat, inducing immunogenic cell death 4T1 breast cancer cells or CT26 colon facilitating production. our vivo prevention treatment model, noted that CE significantly boosted TV. The primary mechanism involves CE's ability lower ratio myeloid-derived suppressor (MDSCs), decrease glucose cells, increase proportions CD8+ T memory cells. Collectively, findings offer promising avenues for designing innovative systems.

Language: Английский

Citations

Light/Ultrasound Dual Responsive Carbon Dots‐Based Nanovaccines for Multimodal Activation Tumor Immunotherapy of Melanoma DOI

Aijia Yang,

Li Chen, Shunxin Tang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Melanoma is a highly aggressive and metastatic tumor, immunotherapy has become the current solution. However, conventional nanovaccines do not strongly activate T cell immune responses. Therefore, development of effective therapeutic to systemic antitumor immunity urgently required. Herein, light/ultrasound (US) dual‐responsive carbon dot‐based (Cu‐N‐CDs@OVA) are designed using copper‐nitrogen‐coordinated dots composited with ovalbumin. Under 650‐nm laser irradiation, Cu‐N‐CDs@OVA exhibited superior photothermal ablation primary tumors, induced immunogenic death released antigens by phototherapy, facilitating maturation dendritic cells (DCs). More importantly, stably penetrated diffused upon US treatment, eradicating tumors generating low‐dose reactive oxygen species DCs. By integrating model antigen OVA, combined multimodal treatment promotes DC systematic immunity. This first example light/US nanovaccine that provides paradigm for production personalized against malignant tumors.

Language: Английский

Citations

Designed amino acid-based deep eutectic solvents as a platform to functionalize biomedical elastomers by polyaddition reactions DOI

Ao Zhen,

Ao Wang,

Xirui Long

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162605 - 162605

Published: April 1, 2025

Language: Английский

Citations

Research progress and prospect of tumor nanovaccine combination therapy strategy DOI

Yanyan Yin, Jun Guo, Shuo Zhang

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110771 - 110771

Published: Dec. 1, 2024

Language: Английский

Citations