Metal Ion-Directed Functional Metal–Phenolic Materials

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(13), P. 11432 - 11473

Published: May 10, 2022

Metal ions are ubiquitous in nature and play significant roles assembling functional materials fields spanning chemistry, biology, science. Metal-phenolic assembled from phenolic components the presence of metal through formation metal-organic complexes. Alkali, alkali-earth, transition, noble as well metalloids interacting with building blocks have been widely exploited to generate diverse hybrid materials. Despite extensive studies on synthesis metal-phenolic materials, a comprehensive summary how guide assembly compounds is lacking. A fundamental understanding engineering will facilitate specific properties. In this review, we focus diversity function material emerging applications. Specifically, discuss range underlying interactions, including (i) cation-π, (ii) coordination, (iii) redox, (iv) dynamic covalent highlight wide properties resulting these interactions. Applications (e.g., biological, catalytic, environmental) perspectives also highlighted.

Language: Английский

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Tannic acid: a crosslinker leading to versatile functional polymeric networks: a review

RSC Advances, Journal Year: 2022, Volume and Issue: 12(13), P. 7689 - 7711

Published: Jan. 1, 2022

With the thriving of mussel-inspired chemistry and demand for low-cost analogues to polydopamine in adhesive design, tannic acid has become a research focus because its wide availability, health benefits special chemical properties.

Language: Английский

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Supramolecular Photothermal Nanomaterials as an Emerging Paradigm toward Precision Cancer Therapy

Advanced Functional Materials, Journal Year: 2018, Volume and Issue: 29(4)

Published: Nov. 30, 2018

Abstract The concept of the “supramolecular photothermal effects” refers to collection property and conversion efficiency resulting from supramolecular assembly molecular sensitizers. This review considers organic materials assembled at nanoscale via various self‐assembly strategies associated with organization multiple noncovalent interactions. In these materials, individual photosensitizer molecules are typically aggregated through in a certain form that exhibits enhanced biostability, increased photoluminescence quenching, improved therapeutic effects comparison those monomeric molecules. These controlled or influenced by intermolecular interactions, especially hydrophobic effects, which distinct mechanisms conventional sensitizer polymers inorganic agents. A focus lies on how give rise including polymer protein fabrication, small molecule self‐assembly, construction donor–acceptor binary systems. Emphases placed rational design nanomaterials, drug delivery, vivo effects. Finally, key challenges promising prospects nanomaterials terms both technical advances clinical translation discussed.

Language: Английский

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Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing

Bioactive Materials, Journal Year: 2021, Volume and Issue: 9, P. 461 - 474

Published: July 26, 2021

Bacterial infection, tissue hypoxia and inflammatory response can hinder the infected wound repair process. To mitigate above issues, tannic acid-chelated Fe-decorated molybdenum disulfide nanosheets (MoS2@TA/Fe NSs) with dual enzyme activities were developed anchored to a multifunctional hydrogel. The hydrogel exhibited excellent antibacterial ability owing combined effects of photothermal therapy (PTT), glutathione (GSH) loss, peroxidase (POD)-like activity (catalyse H2O2 into ·OH under acid condition) MoS2@TA/Fe NSs. Benefitting from catalase (CAT)-like activity, could decompose O2 at neutral pH relieve supply adequate O2. POD-like was mainly attributed MoS2 NSs, while CAT-like primarily due TA/Fe complex. Moreover, NSs endowed outstanding anti-oxidant scavenge redundant reactive oxygen species (ROS) nitrogen (RNS) environment maintain balance antioxidant systems prevent inflammation. In addition, inhibit release factors for anti-inflammatory property TA. TA retained partial phenolic hydroxyl groups, which cross-linked network structure promoted adhesion hydrogels. Due dynamic boron ester bonds between polyvinyl alcohol (PVA), dextran (Dex), MoS2@TA/Fe, borax, demonstrated fast self-healing rapid shape adaptability. This shape-adaptable adhesive fill whole closely contact wound, ensuring that it achieved its functions maximum efficiency. nanozyme-anchored showed high potential bacteria-infected healing.

Language: Английский

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Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: July 19, 2019

Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes the fused cells (FCs) derived from dendritic (DCs) as tumor vaccines. The fusion immunologically interrelated two types results strong expression whole antigen complexes immunological co-stimulatory molecules on (FMs), allowing nanoparticle-supported FM (NP@FM) to function like presenting (APCs) for T cell immunoactivation. Moreover, tumor-antigen bearing NP@FM can be bio-recognized by DCs induce DC-mediated combination these immunoactivation pathways offers powerful antitumor immunoresponse. Through mimicking both APCs this cytomembrane vaccine strategy develop various toward multiple provide chances accommodating diverse functions originating supporters.

Language: Английский

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Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(7), P. 4432 - 4483

Published: Jan. 1, 2021

Phenolics are ubiquitous in nature and have gained immense research attention because of their unique physiochemical properties widespread industrial use. In recent decades, accessibility, versatile reactivity, relative biocompatibility catalysed phenolic-enabled nanotechnology (PEN) particularly for biomedical applications which been a major benefactor this emergence, as largely demonstrated by polydopamine polyphenols. Therefore, it is imperative to overveiw the fundamental mechanisms synthetic strategies PEN state-of-the-art provide timely comprehensive summary. review, we will focus on principles involved summarize use toolkit particle engineering bottom-up synthesis nanohybrid materials. Specifically, discuss attractive forces between phenolics complementary structural motifs confined systems synthesize high-quality products with controllable size, shape, composition, well surface chemistry function. Additionally, phenolic's numerous biosensing, bioimaging, disease treatment be highlighted. This review aims guidelines new scientists field serve an up-to-date compilation what has achieved area, while offering expert perspectives PEN's translational research.

Language: Английский

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Tannic acid-based metal phenolic networks for bio-applications: a review

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(20), P. 4098 - 4110

Published: Jan. 1, 2021

Strategic design for the fabrication of tannic acid-based metal phenolic networks. Various applications networks in biomedical fields.

Language: Английский

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Ferroptosis Promotes Photodynamic Therapy: Supramolecular Photosensitizer-Inducer Nanodrug for Enhanced Cancer Treatment

Theranostics, Journal Year: 2019, Volume and Issue: 9(11), P. 3293 - 3307

Published: Jan. 1, 2019

The noninvasive nature of photodynamic therapy (PDT) enables the preservation organ function in cancer patients.However, PDT is impeded by hypoxia tumor microenvironment (TME) caused high intracellular oxygen (O 2 ) consumption and distorted blood vessels.Therefore, increasing generation TME would be a promising methodology for enhancing PDT.Herein, we proposed concept ferroptosis-promoted based on biochemical characteristics cellular ferroptosis, which improved efficacy significantly producing reactive species (ROS) supplying O sustainably through Fenton reaction.In contrast to traditional strategies that increase decomposition limited concentration hydrogen peroxide (H ), our could maintain H reaction.Methods: For its association with sensitivity solute carrier family 7 member 11 (SLC7A11) expression was characterized bioinformatics analysis immunohistochemistry oral tongue squamous cell carcinoma (OTSCC) specimens.Afterwards, photosensitizer chlorin e6 (Ce6) ferroptosis inducer erastin were self-assembled into novel supramolecular Ce6-erastin nanodrug bonding π-π stacking.Then, obtained extensively anti-tumor towards OTSCC evaluated both vitro vivo.Results: SLC7A11 found upregulated OTSCC, potential target ferroptosis-mediated treatment.Ce6-erastin nanoparticles exhibited low cytotoxicity normal tissues.More significantly, over-accumulated ROS, increased inhibited lead enhanced toxicity CAL-27 cells satisfactory antitumor effects xenograft tumour mouse model upon irradiation.Conclusion: Our promoted approach markedly enhances anticancer actions relieving promoting ROS production, thereby work provides new overcoming hypoxia-associated resistance treatment.

Language: Английский

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In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS‐Mediated Anticancer Therapy

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 30(4)

Published: Nov. 4, 2019

The combination of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic (CDT) holds great promise for enhancing ROS-mediated cancer treatment. Herein, we reported an in situ polymerized hollow mesoporous organosilica nanoparticle (HMON) biocatalysis nanoreactor to integrate the synergistic effect PDT/CDT pancreatic ductal adenocarcinoma HPPH photosensitizer was hybridized within framework HMON via "in growth" approach. Then, cavity HMONs exploited as a polymerization" synthesize polymer containing thiol groups, thereby enabling immobilization ultrasmall gold nanoparticles, which behave like glucose oxidase-like nanozyme, converting into H2O2 provide self-supplied CDT. Meanwhile, Cu2+-tannic acid complexes were further deposited on surface (HMON-Au@Cu-TA) initiate Fenton-like reaction covert •OH, highly toxic ROS. Finally, collagenase (Col), can degrade collagen I fiber extracellular matrix (ECM), loaded HMON-Au@Cu-TA enhance penetration O2 infiltration enhanced PDT. This study provides good paradigm anti-tumor efficacy. this research offers new method broaden application silica based nanotheranostics.

Language: Английский

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Facile fabrication of hydroxyapatite-magnetite-bentonite composite for efficient adsorption of Pb(II), Cd(II), and crystal violet from aqueous solution

Journal of Cleaner Production, Journal Year: 2019, Volume and Issue: 247, P. 119088 - 119088

Published: Nov. 3, 2019

Language: Английский

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