Macromolecular Bioscience,
Journal Year:
2020,
Volume and Issue:
21(1)
Published: Sept. 3, 2020
Abstract
Bacterial
infectious
diseases
and
bacterial‐infected
environments
have
been
threatening
the
health
of
human
beings
all
over
world.
In
view
increased
bacteria
resistance
caused
by
overuse
or
improper
use
antibiotics,
antibacterial
biomaterials
are
developed
as
substitutes
for
antibiotics
in
some
cases.
Among
them,
hydrogels
attracting
more
attention
due
to
easy
preparation
process
diversity
structures
changing
their
chemical
cross‐linkers
via
covalent
bonds
noncovalent
physical
interactions,
which
can
endow
them
with
various
specific
functions
such
high
toughness
stretchability,
injectability,
self‐healing,
tissue
adhesiveness
rapid
hemostasis,
loading
controlled
drug
release,
superior
biocompatibility
antioxidation
well
good
conductivity.
this
review,
recent
progress
hydrogel
including
fabrication
methodologies,
interior
structures,
performances,
mechanisms,
applications
is
summarized.
According
bacteria‐killing
modes
hydrogels,
several
representative
silver
nanoparticles‐based
hydrogel,
photoresponsive
photothermal
photocatalytic,
self‐bacteria‐killing
inherent
peptides
cationic
polymers,
antibiotics‐loading
focused
on.
Furthermore,
current
challenges
discussed
future
perspectives
field
also
proposed.
Advanced Materials,
Journal Year:
2019,
Volume and Issue:
31(18)
Published: March 25, 2019
Using
the
cytomembranes
(FMs)
of
hybrid
cells
acquired
from
fusion
cancer
and
dendritic
(DCs),
this
study
offers
a
biologically
derived
platform
for
combination
immunotherapy
traditional
oncotherapy
approaches.
Due
to
immunoactivation
implicated
in
cellular
fusion,
FMs
can
effectively
express
whole
antigens
immunological
co-stimulatory
molecules
robust
immunotherapy.
share
tumor's
self-targeting
character
with
parent
cells.
In
bilateral
tumor-bearing
mouse
models,
FM-coated
nanophotosensitizer
causes
durable
immunoresponse
inhibit
rebound
primary
tumors
post-nanophotosensitizer-induced
photodynamic
therapy
(PDT).
The
FM-induced
displays
ultrahigh
antitumor
effects
even
comparable
that
PDT.
On
other
hand,
PDT
toward
enhances
immunotherapy-caused
regression
irradiation-free
distant
tumors.
Consequently,
both
are
almost
completely
eliminated.
This
tumor-specific
immunotherapy-based
nanoplatform
is
potentially
expandable
multiple
tumor
types
readily
equipped
diverse
functions
owing
flexible
nanoparticle
options.
Giant,
Journal Year:
2020,
Volume and Issue:
3, P. 100022 - 100022
Published: Aug. 1, 2020
Natural
polyphenols
have
attracted
great
interests
in
medicine,
food
and
cosmetics
due
to
their
versatile
functions
such
as
antioxidant,
anticancer
antibacterial.
The
polyphenolic
structures
(i.e.
catechol,
pyrogallol)
natural
are
responsible
for
strong
noncovalent
interactions
via
multiple
hydrogen
bonding
hydrophobic
interactions,
dynamic
covalent
complexation
with
boronate
groups
metal
ions.
In
this
review,
we
focused
on
the
preparation
applications
of
polyphenol-based
coating
films,
nanoparticles,
nanocapsules,
hydrogels
emerged
from
chemical
functional
signatures.
beneficial
role
mechanism
facilitating
delivery
proteins,
nucleic
acids
conventional
drug
molecules
were
reviewed.
Finally,
challenges
systems
perspectives
rational
design
next
generation
polyphenol
biomaterials
will
be
discussed.
ACS Applied Materials & Interfaces,
Journal Year:
2019,
Volume and Issue:
11(5), P. 4745 - 4756
Published: Jan. 14, 2019
Magnetic
microrobots
can
be
actuated
in
fuel-free
conditions
and
are
envisioned
for
biomedical
applications
related
to
targeted
delivery
therapy
a
minimally
invasive
manner.
However,
mass
fabrication
of
with
precise
propulsion
performance
excellent
therapeutic
efficacy
is
still
challenging,
especially
predictable
controllable
Herein,
we
propose
facile
technique
production
magnetic
multiple
functions
using
Spirulina
(
Sp.)
as
biotemplate.
Core-shell-structured
Pd@Au
nanoparticles
(NPs)
were
synthesized
Sp.
cells
by
electroless
deposition,
working
photothermal
conversion
agents.
Subsequently,
the
Fe3O4
NPs
deposited
onto
surface
obtained
(Pd@Au)@
particles
via
sol-gel
process,
enabling
them
magnetically
actuated.
Moreover,
anticancer
drug
doxorubicin
(DOX)
was
loaded
on
(Pd@Au)/Fe3O4@
microrobots,
which
endows
additional
chemotherapeutic
efficacy.
The
as-prepared
biohybrid
Sp.-DOX
not
only
possess
efficient
highest
speed
526.2
μm/s
under
rotating
field
but
also
have
enhanced
synergistic
chemo-photothermal
Furthermore,
they
structurally
disassembled
into
individual
near-infrared
(NIR)
laser
irradiation
exhibit
pH-
NIR-triggered
release.
These
intriguing
properties
enable
very
promising
platform
loading,
delivery,
therapy.
Macromolecular Bioscience,
Journal Year:
2020,
Volume and Issue:
21(1)
Published: Sept. 3, 2020
Abstract
Bacterial
infectious
diseases
and
bacterial‐infected
environments
have
been
threatening
the
health
of
human
beings
all
over
world.
In
view
increased
bacteria
resistance
caused
by
overuse
or
improper
use
antibiotics,
antibacterial
biomaterials
are
developed
as
substitutes
for
antibiotics
in
some
cases.
Among
them,
hydrogels
attracting
more
attention
due
to
easy
preparation
process
diversity
structures
changing
their
chemical
cross‐linkers
via
covalent
bonds
noncovalent
physical
interactions,
which
can
endow
them
with
various
specific
functions
such
high
toughness
stretchability,
injectability,
self‐healing,
tissue
adhesiveness
rapid
hemostasis,
loading
controlled
drug
release,
superior
biocompatibility
antioxidation
well
good
conductivity.
this
review,
recent
progress
hydrogel
including
fabrication
methodologies,
interior
structures,
performances,
mechanisms,
applications
is
summarized.
According
bacteria‐killing
modes
hydrogels,
several
representative
silver
nanoparticles‐based
hydrogel,
photoresponsive
photothermal
photocatalytic,
self‐bacteria‐killing
inherent
peptides
cationic
polymers,
antibiotics‐loading
focused
on.
Furthermore,
current
challenges
discussed
future
perspectives
field
also
proposed.
