ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(6), P. 2266 - 2276
Published: June 5, 2023
Fruits
are
safe,
toxin-free,
and
biomolecule-rich
raw
materials
that
may
be
utilized
to
decrease
metal
ions
stabilize
nanoparticles.
Here,
we
demonstrate
the
green
synthesis
of
magnetite
nanoparticles
which
were
first
capped
with
a
layer
silica,
followed
by
decoration
silver
nanoparticles,
termed
Ag@SiO2@Fe3O4,
using
lemon
fruit
extract
as
reducing
agent
in
size
range
∼90
nm.
The
effect
stabilizer
on
characteristics
was
examined
via
different
spectroscopy
techniques,
elemental
composition
multilayer-coated
structures
verified.
saturation
magnetization
bare
Fe3O4
at
room
temperature
recorded
78.5
emu/g,
whereas
it
decreased
56.4
43.8
emu/g
for
silica
coating
subsequent
All
displayed
superparamagnetic
behavior
almost
zero
coercivity.
While
further
processes,
specific
surface
area
increased
from
67
180
m2
g–1
after
addition
reached
98
g–1,
can
explained
organization
an
island-like
model.
Zeta
potential
values
also
−18
−34
mV
coating,
indicating
enhanced
stabilization
silver.
antibacterial
tests
against
Escherichia
coli
(E.
coli)
Staphylococcus
aureus
(S.
aureus)
revealed
SiO2@Fe3O4
did
not
show
sufficient
effect,
while
even
low
concentrations
(≤
200
μg/mL),
high
activity
due
existence
atoms
Furthermore,
vitro
cytotoxicity
assay
Ag@SiO2@Fe3O4
toxic
HSF-1184
cells
μg/mL
concentration.
Antibacterial
during
consecutive
magnetic
separation
recycling
steps
investigated,
offered
more
than
10
cycles
recycling,
making
them
potentially
useful
biomedical
fields.
Journal of Controlled Release,
Journal Year:
2022,
Volume and Issue:
351, P. 50 - 80
Published: Sept. 20, 2022
The
site-specific
delivery
of
antitumor
agents
is
importance
for
providing
effective
cancer
suppression.
Poor
bioavailability
anticancer
compounds
and
the
presence
biological
barriers
prevent
their
accumulation
in
tumor
sites.
These
obstacles
can
be
overcome
using
liposomal
nanostructures.
challenges
chemotherapy
stimuli-responsive
nanocarriers
are
first
described
current
review.
Then,
liposomes
including
pH-,
redox-,
enzyme-,
light-,
thermo-
magneto-sensitive
nanoparticles
discussed
potential
drugs
emphasized.
pH-
or
redox-sensitive
based
on
internal
stimulus
release
drug
response
to
a
mildly
acidic
pH
GSH,
respectively.
pH-sensitive
mediate
endosomal
escape
via
proton
sponge.
multifunctional
responsive
both
redox
have
more
capacity
at
site
compared
alone.
magnetic
field
NIR
irradiation
exploited
external
stimulation
liposomes.
light-responsive
when
they
exposed
irradiation;
thermosensitive-liposomes
temperature
>40
°C
there
hyperthermia;
magneto-responsive
field.
smart
nanoliposomes
also
co-delivery
genes
synergistic
therapy.
Due
lack
long-term
toxicity
liposomes,
utilized
near
future
treatment
patients.
Medicinal Research Reviews,
Journal Year:
2023,
Volume and Issue:
43(6), P. 2115 - 2176
Published: May 11, 2023
Abstract
Breast
cancer
is
the
most
malignant
tumor
in
women,
and
there
no
absolute
cure
for
it.
Although
treatment
modalities
including
surgery,
chemotherapy,
radiotherapy
are
utilized
breast
cancer,
it
still
a
life‐threatening
disease
humans.
Nanomedicine
has
provided
new
opportunity
treatment,
which
focus
of
current
study.
The
nanocarriers
deliver
chemotherapeutic
agents
natural
products,
both
increase
cytotoxicity
against
cells
prevent
development
drug
resistance.
efficacy
gene
therapy
boosted
by
nanoparticles
delivery
CRISPR/Cas9,
Noncoding
RNAs,
RNAi,
promoting
their
potential
expression
regulation.
codelivery
can
exert
synergistic
impact
on
tumors
enhance
cellular
uptake
via
endocytosis.
Nanostructures
able
to
induce
photothermal
photodynamic
ablation
cell
death
induction.
provide
microenvironment
remodeling
repolarization
macrophages
antitumor
immunity.
stimuli‐responsive
nanocarriers,
pH‐,
redox‐,
light‐sensitive,
mediate
targeted
suppression
tumors.
Besides,
diagnosis
detect
biomarkers.
Various
kinds
have
been
employed
therapy,
carbon‐,
lipid‐,
polymeric‐
metal‐based
nanostructures,
different
terms
biocompatibility
efficiency.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(3)
Published: Jan. 17, 2024
Abstract
Reactive
oxygen
species
play
a
crucial
role
in
cell
signaling
pathways
during
wound
healing
phases.
Treatment
strategies
to
balance
the
redox
level
deep
tissue
are
emerging
for
management.
In
recent
years,
reactive
scavenging
agents
including
natural
antioxidants,
(ROS)
nanozymes,
and
antioxidant
delivery
systems
have
been
widely
employed
inhibit
oxidative
stress
promote
skin
regeneration.
Here,
importance
of
different
phases
is
critically
analyzed.
Various
cutting‐edge
bioactive
ROS
nanoscavengers
platforms
discussed.
This
review
also
highlights
future
directions
therapies
via
scavenging.
comprehensive
offers
map
research
on
scavengers
with
balancing
mechanisms
action
process,
which
benefits
development
clinical
applications
next‐generation
scavenging‐based
nanomaterials
Advanced Composites and Hybrid Materials,
Journal Year:
2023,
Volume and Issue:
6(1)
Published: Jan. 31, 2023
Abstract
Bio-responsive
nanocomposites
with
facile
fabrication
and
rational
design
are
of
great
importance
in
the
diagnosis
treatment
cancer.
Herein,
combination
bioimaging
due
to
presence
QD
controlled
drug
delivery
via
nanogel
was
employed
for
cancer
treatment.
To
this
aim,
we
fabricated
a
traceable
bioresponsive
fluorescent
active
composite
by
integrating
creatinine-functionalized
carbon
dots
(QD)
into
lecithin-inulin
nanogel.
Subsequently,
PEGylation
integration
herceptin
on
were
carried
out
improve
biofate
its
ability
target
HER2-positive
breast
The
assessment
cellular
uptake
demonstrated
that
effectively
internalized
SK-BR-3
cells
production
reactive
oxygen
species
significantly
boosted.
Moreover,
led
high
expression
P53
Bax
genes
along
low
Bcl-2
gene
(as
promotors
apoptosis
signaling
pathway).
enhanced.
It
inhibiting
proliferation
as
well
reduction
viability
(HER-2
positive)
compared
MDA-MB-231
(triple-negative).
intraperitoneal
injection
developed
formulation
MCF-7
cell-bearing
BALB/c
mice
supported
observation
tumor
growth
inhibition.
Overall,
herceptin-adorned
PEGylated
can
be
promising
theranostic
candidate
targeting
HER-2-positive
Graphical
Small,
Journal Year:
2024,
Volume and Issue:
20(30)
Published: March 7, 2024
Abstract
In
recent
years,
there
has
been
growing
interest
in
developing
innovative
materials
and
therapeutic
strategies
to
enhance
wound
healing
outcomes,
especially
for
chronic
wounds
antimicrobial
resistance.
Metal–organic
frameworks
(MOFs)
represent
a
promising
class
of
next‐generation
dressings.
Their
high
surface
area,
pore
structures,
stimuli‐responsiveness,
antibacterial
properties,
biocompatibility,
potential
combination
therapies
make
them
suitable
complex
care
challenges.
MOF‐based
composites
promote
cell
proliferation,
angiogenesis,
matrix
synthesis,
acting
as
carriers
bioactive
molecules
promoting
tissue
regeneration.
They
also
have
stimuli‐responsivity,
enabling
photothermal
skin
cancer
infections.
Herein,
critical
analysis
the
current
state
research
on
MOFs
dressings
is
provided,
offering
valuable
insights
into
applications,
challenges,
future
directions
this
field.
This
literature
review
targeted
multifunctionality
nature
wound‐disease
therapy
from
different
aspects
discussed
most
advancements
made
context,
reader
will
find
how
contributed
field
yield
more
effective,
functional,
they
lead
next
generation
biomaterials
