Degradability and Clearance of Inorganic Nanoparticles for Biomedical Applications

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(10)

Published: Jan. 7, 2019

Inorganic nanoparticles with tunable and diverse properties hold tremendous potential in the field of nanomedicine, while having non-negligible toxicity concerns healthy tissues/organs that have resulted their restricted clinical translation to date. In past decade, emergence biodegradable or clearable inorganic has made it possible completely solve this long-standing conundrum. A comprehensive understanding design these metabolic performance body is crucial importance advance trials expand biological applications disease diagnosis. Here, a variety regarding considerations size, morphology, surface chemistry, doping strategy are highlighted. Their pharmacokinetics, pathways metabolism body, time required for excretion discussed. Some materials intrinsically responsive various conditions tumor microenvironment also introduced. Finally, an overview encountered challenges provided along outlook applying toward future translations.

Language: Английский

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Inorganic nanomaterials with rapid clearance for biomedical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8669 - 8742

Published: Jan. 1, 2021

Inorganic nanomaterials that have inherently exceptional physicochemical properties (e.g., catalytic, optical, thermal, electrical, or magnetic performance) can provide desirable functionality drug delivery, diagnostics, imaging, therapy) considerable potential for application in the field of biomedicine. However, toxicity be caused by long-term, non-specific accumulation these inorganic healthy tissues, preventing their large-scale clinical utilization. Over past several decades, emergence biodegradable and clearable has offered to prevent such long-term toxicity. In addition, a comprehensive understanding design metabolic pathways within body is essential enabling expansion theranostic applications various diseases advancing trials. Thus, it critical importance develop biomedical applications. This review systematically summarizes recent progress nanomaterials, particularly cancer theranostics other disease therapies. The future prospects opportunities this rapidly growing are also discussed. We believe timely will stimulate guide additional in-depth studies area nanomedicine, as rapid vivo clearance degradation likely prerequisite translation with unique functionality.

Language: Английский

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Ultrasound-Augmented Mitochondrial Calcium Ion Overload by Calcium Nanomodulator to Induce Immunogenic Cell Death

Nano Letters, Journal Year: 2021, Volume and Issue: 21(5), P. 2088 - 2093

Published: Feb. 17, 2021

Immunogenic cell death (ICD), a manner of tumor that can trigger antitumor immune responses, has received extensive attention as potential synergistic modality for cancer immunotherapy. Although many calcium ion (Ca2+) nanomodulators have been developed therapy through mitochondrial Ca2+ overload, their ICD-inducing properties not explored. Herein, an acid-sensitive PEG-decorated carbonate (CaCO3) nanoparticle incorporating curcumin (CUR; enhancer) (PEGCaCUR) was prepared using simple one-pot strategy. PEGCaCUR served only nanomodulator inducing efficient overload but also ICD inducer during improved therapy. Combination with ultrasound (US), PEGCaCUR+US, led to enhanced effect attributable the along subsequent upregulation reactive oxygen species levels. facilitates photoacoustic/fluorescence dual-mode imaging, well effectively suppressing growth and metastasis, indicating promising theranostic properties.

Language: Английский

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Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress

Chem, Journal Year: 2020, Volume and Issue: 6(6), P. 1391 - 1407

Published: March 20, 2020

Language: Английский

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A Multichannel Ca²⁺ Nanomodulator for Multilevel Mitochondrial Destruction‐Mediated Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(15)

Published: March 6, 2021

Subcellular organelle-targeted nanoformulations for cancer theranostics are receiving increasing attention owing to their benefits of precise drug delivery, maximized therapeutic index, and reduced off-target side effects. Herein, a multichannel calcium ion (Ca

Language: Английский

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Light: A Magical Tool for Controlled Drug Delivery

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(49)

Published: Sept. 9, 2020

Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal spatial control. Great progress has been achieved in the development novel light-driven strategies with both breadth depth. Light-controlled platforms can be generally categorized into three groups: photochemical, photothermal, photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, sulfides oxides, metal-organic frameworks, carbon nanomaterials, upconversion semiconductor stimuli-responsive micelles, polymer- liposome-based nanoparticles have applied light-stimulated delivery. In view increasing interest targeted delivery, we review light-responsive systems focus on recent advances, key limitations, future directions.

Language: Английский

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Transformable Nanosensitizer with Tumor Microenvironment‐Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(25), P. 14051 - 14059

Published: April 2, 2021

Abstract Despite the promise of sonodynamic processes in cancer therapy, existing sonosensitizers often fail to regulate generation reactive oxygen species (ROS) against tumors, potentially leading off‐target toxicity normal tissues. We report a transformable core‐shell nanosonosensitizer (TiO 2 @CaP) that reinvigorates ROS and dissolves its CaP shell release Ca 2+ an acidic tumor microenvironment (TME) under ultrasound activation. Thus, TiO @CaP acts as smart specifically induces mitochondrial dysfunction via overloading intracellular ions synergize with process TME. substantially enhances immunogenic cell death, resulting enhanced T‐cell recruitment infiltration into cold (4T1). In conjunction checkpoint blockade therapy (anti‐PD 1), @CaP‐mediated elicits systemic antitumor immunity, regression non‐treated distant tumors inhibition lung metastasis. This work paves way development “smart” TME‐activatable temporospatial control over responses.

Language: Английский

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The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

Advanced Science, Journal Year: 2020, Volume and Issue: 7(21)

Published: Aug. 16, 2020

As an essential trace element in the human body, transitional metal copper (Cu) ions are bioactive components within body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology nanomedicine promote emerging distinctive Cu-involved biomaterial nanoplatforms with intriguing theranostic performances biomedicine, which originated from Cu species physiochemical attributes Cu-composed nanoparticles. Based on very-recent significant progresses nanotheranostics, this work highlights discusses principles, progresses, prospects elaborate design rational construction functional for a diverse array biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, bioimaging. engineering Cu-based nanocomposites synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biosafety revolutionizing clinical translation. Finally, underlying critical concerns, unresolved hurdles, future uses analyzed outlook provided. By entering "Copper Age," these nanotherapeutic modalities expected to find more broad applications preclinical phases, despite current research developments still being infancy.

Language: Английский

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RBC membrane camouflaged prussian blue nanoparticles for gamabutolin loading and combined chemo/photothermal therapy of breast cancer

Biomaterials, Journal Year: 2019, Volume and Issue: 217, P. 119301 - 119301

Published: June 25, 2019

Language: Английский

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Biodegradable Ca²⁺ Nanomodulators Activate Pyroptosis through Mitochondrial Ca²⁺ Overload for Cancer Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(36)

Published: June 10, 2022

Abstract Pyroptosis provides a new direction and broad prospects for cancer immunotherapy. However, the development of nanoplatform as pyroptosis inducer is limited, discovery type nano‐pyroptosis immunotherapy still imminent. Herein, biodegradable Ca 2+ nanomodulators (CaNMs) are prepared inducers via mitochondrial overload. The obtained CaNMs can decompose under low pH to release curcumin, leading sudden surge in ions, eventually resulting pyroptosis. We not only confirm occurrence overload‐triggered first time but also reveal robust immune responses CaNMs, along with remarkably suppressing tumor proliferation lung metastasis. This work will provide strategies inspiration pyroptosis‐mediated treatments, greatly contributing further nanomodulators.

Language: Английский

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