Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(20)
Published: March 10, 2023
The
development
of
covalent
organic
framework
(COF)
sonosensitizers
with
intrinsic
sonodynamic
effects
is
highly
desirable.
However,
such
COFs
are
generally
constructed
using
small-molecule
photosensitizers.
Herein,
we
report
that
the
reticular
chemistry-based
synthesis
from
two
inert
monomers
yields
a
COF-based
sonosensitizer
(TPE-NN)
inherent
activity.
Subsequently,
nanoscale
COF
TPE-NN
fabricated
and
embedded
copper
(Cu)-coordinated
sites
to
obtain
TPE-NN-Cu.
Results
show
Cu
coordination
can
enhance
effect
TPE-NN,
whereas
ultrasound
(US)
irradiation
for
therapy
augment
chemodynamic
efficacy
Consequently,
TPE-NN-Cu
upon
US
shows
high-performance
anticancer
based
on
mutually
reinforced
sono-/chemo-nanodynamic
therapy.
This
study
reveals
backbone-originated
activity
proposes
paradigm
nanodynamic
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: May 25, 2023
Abstract
Blood–brain
barrier
(BBB)
is
a
natural
protective
membrane
that
prevents
central
nervous
system
(CNS)
from
toxins
and
pathogens
in
blood.
However,
the
presence
of
BBB
complicates
pharmacotherapy
for
CNS
disorders
as
most
chemical
drugs
biopharmaceuticals
have
been
impeded
to
enter
brain.
Insufficient
drug
delivery
into
brain
leads
low
therapeutic
efficacy
well
aggravated
side
effects
due
accumulation
other
organs
tissues.
Recent
breakthrough
materials
science
nanotechnology
provides
library
advanced
with
customized
structure
property
serving
powerful
toolkit
targeted
delivery.
In-depth
research
field
anatomical
pathological
study
on
further
facilitates
development
brain-targeted
strategies
enhanced
crossing.
In
this
review,
physiological
different
cells
contributing
are
summarized.
Various
emerging
permeability
regulation
crossing
including
passive
transcytosis,
intranasal
administration,
ligands
conjugation,
coating,
stimuli-triggered
disruption,
overcome
obstacle
highlighted.
Versatile
systems
ranging
organic,
inorganic,
biologics-derived
their
synthesis
procedures
unique
physio-chemical
properties
summarized
analyzed.
This
review
aims
provide
an
up-to-date
comprehensive
guideline
researchers
diverse
fields,
offering
perspectives
system.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(18), P. 3226 - 3226
Published: Sept. 16, 2022
Nanomaterials
are
materials
with
one
or
more
nanoscale
dimensions
(internal
external)
(i.e.,
1
to
100
nm).
The
nanomaterial
shape,
size,
porosity,
surface
chemistry,
and
composition
controlled
at
the
nanoscale,
this
offers
interesting
properties
compared
bulk
materials.
This
review
describes
how
nanomaterials
classified,
their
fabrication,
functionalization
techniques,
growth-controlled
mechanisms.
First,
history
of
is
summarized
then
different
classification
methods,
based
on
dimensionality
(0–3D),
(carbon,
inorganic,
organic,
hybrids),
origin
(natural,
incidental,
engineered,
bioinspired),
crystal
phase
(single
phase,
multiphase),
dispersion
state
(dispersed
aggregated),
presented.
Then,
synthesis
methods
discussed
classified
in
function
starting
material
(bottom-up
top-down),
reaction
(gas,
plasma,
liquid,
solid),
nature
dispersing
forces
(mechanical,
physical,
chemical,
physicochemical,
biological).
Finally,
challenges
synthesizing
for
research
commercial
use
highlighted.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(49)
Published: Oct. 4, 2022
The
development
of
efficient
organic
sonosensitizers
is
crucial
for
sonodynamic
therapy
(SDT)
in
the
field
cancer
treatment.
Herein,
a
new
strategy
based
on
triarylboron-doped
acenethiophene
scaffolds
presented.
attachment
boron
to
linear
acenethiophenes
lowers
lowest
unoccupied
molecular
orbital
(LUMO)
energy,
resulting
redshifted
absorptions
and
emissions.
After
encapsulation
with
amphiphilic
polymer
DSPE-mPEG2000
,
it
found
that
nanostructured
BAnTh-NPs
BTeTh-NPs
(nanoparticles
BAnTh
BTeTh)
shows
hydroxyl
radical
(•
OH)
generation
under
ultrasound
(US)
irradiation
aqueous
solution
almost
no
phototoxicity,
which
can
overcome
shortcomings
O2
-dependent
SDT
avoid
potential
cutaneous
phototoxicity
issue.
In
vitro
vivo
therapeutic
results
validate
boron-doped
as
enable
high
efficiency
low
good
biocompatibility,
indicating
boron-functionalization
acenes
promising
toward
SDT.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(6), P. 2031 - 2081
Published: Jan. 1, 2023
Bioactive
materials
are
a
special
class
of
biomaterials
that
can
react
in
vivo
to
induce
biological
response
or
regulate
functions,
thus
achieving
better
curative
effect
than
traditional
inert
biomaterials.
For
cancer
theranostics,
compared
with
organic
polymer
nanomaterials,
inorganic
nanomaterials
possess
unique
physical
and
chemical
properties,
have
stronger
mechanical
stability
on
the
basis
maintaining
certain
bioactivity,
easy
be
compounded
various
carriers
(polymer
carriers,
etc.),
so
as
achieve
specific
antitumor
efficacy.
After
entering
nanoscale,
due
nano-size
effect,
high
surface
area
nanostructures,
exhibit
effects,
which
significantly
influence
interaction
organisms.
Therefore,
research
applications
bioactive
theranostics
attracted
wide
attention.
In
this
review,
we
mainly
summarize
recent
progress
also
introduce
definition,
synthesis
modification
strategies
nanomaterials.
Thereafter,
tumor
imaging
therapy,
including
microenvironment
(TME)
regulation,
catalytic
gas
regulatory
cell
death
immunotherapy,
discussed.
Finally,
biosafety
challenges
mentioned,
their
future
development
opportunities
prospected.
This
review
highlights
bioapplication
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(29)
Published: March 3, 2022
Abstract
Atherosclerosis
is
considered
one
of
the
primary
causes
cardiovascular
diseases
(CVDs).
Unpredictable
rupture
vulnerable
atherosclerotic
plaques
triggers
adverse
events
such
as
acute
myocardial
syndrome
and
even
sudden
cardiac
death.
Therefore,
assessing
vulnerability
early
intervention
are
significance
in
reducing
CVD
mortality.
Nanomedicine
possesses
tremendous
advantages
achieving
integration
diagnosis
therapy
because
its
magnetic,
optical,
thermal,
catalytic
properties.
Based
on
pathological
characteristics
plaques,
stimuli‐responsive
nanoplatforms
surface‐functionalized
nanoagents
designed
have
drawn
great
attention
for
accomplishing
precise
imaging
treatment
due
to
their
superior
properties,
high
bioavailability,
lesion‐targeting
specificity,
on‐demand
cargo
release,
low
off‐target
damage.
Here,
generalized,
some
targeted
strategies
boosting
accuracy
plaque
evaluation
by
efficacy
stabilization
(including
antioxidant
therapy,
macrophage
depletion
regulation
lipid
metabolism
anti‐inflammation
etc.)
systematically
summarized.
In
addition,
existing
challenges
prospects
this
field
discussed,
it
believed
provide
new
thinking
CVDs
near
future.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
32(4)
Published: Oct. 23, 2021
Abstract
Surface‐independent
smart
antibacterial
coatings
with
on‐demand
antibiotics
release
profiles
have
attracted
increasing
attention
in
medical
instruments,
delivery
platforms,
and
implanted
devices.
Although
several
approaches
been
well
documented,
the
facile
preparation
of
onto
universal
substrates
high
loading
efficiencies,
tunable
drug
profiles,
excellent
performances
is
still
met
many
challenges,
especially
related
to
redundant
coating
material
synthesis
selective
substrate
fabrication
process.
To
resolve
this
issue,
authors
report
a
robust
method
towards
surfaces
on
various
via
one‐pot
integration
two
types
naturally
occurring
building
blocks,
aminoglycosides
protocatechualdehyde
presence
plant
enzyme
horseradish
peroxidase.
The
simultaneous
dynamic
imine
bonds
formation
enzymatic
polymerization
within
system
during
reaction
enable
diverse
surface‐independent
coatings,
which
can
demonstrate
promising
features
including
(i.e.,
pH‐responsive)
properties,
behaviors,
efficient
activities
both
vitro
vivo.
This
work
may
offer
new
opportunities
materials
by
bioinspired
all
natural
blocks.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
13, P. 100197 - 100197
Published: Jan. 1, 2022
Photothermal
(PT)-enhanced
Fenton-based
chemodynamic
therapy
(CDT)
has
attracted
a
significant
amount
of
research
attention
over
the
last
five
years
as
highly
effective,
safe,
and
tumor-specific
nanomedicine-based
therapy.
CDT
is
new
emerging
nanocatalyst-based
therapeutic
strategy
for
in
situ
treatment
tumors
via
Fenton
reaction
or
Fenton-like
reaction,
which
got
fast
progress
recent
because
its
high
specificity
activation
by
endogenous
substances.
A
variety
multifunctional
nanomaterials
such
metal-,
metal
oxide-,
metal-sulfide-based
nanocatalysts
have
been
designed
constructed
to
trigger
within
tumor
microenvironment
(TME)
generate
cytotoxic
hydroxyl
radicals
(•OH),
efficient
killing
cells.
However,
still
required
enhance
curative
outcomes
minimize
side
effects.
Specifically,
efficiency
certain
CDTs
hindered
TME,
including
low
levels
hydrogen
peroxide
(H2O2),
overexpression
reduced
glutathione
(GSH),
catalytic
efficacy
reactions
(pH
5.6-6.8),
makes
it
difficult
completely
cure
cancer
using
monotherapy.
For
this
reason,
photothermal
(PTT)
utilized
combination
with
efficacy.
More
interestingly,
heating
during
PTT
not
only
causes
damage
cells
but
can
also
accelerate
generation
•OH
reactions,
thus
enhancing
efficacy,
providing
more
effective
when
compared
Currently,
synergistic
PT-enhanced
both
PT
properties
made
enormous
theranostics.
there
no
comprehensive
review
on
subject
published
date.
In
review,
we
first
summarize
treatment.
We
then
discuss
potential
challenges
future
development
nanocatalytic
clinical
application.
Nano-Micro Letters,
Journal Year:
2022,
Volume and Issue:
14(1)
Published: July 18, 2022
As
the
indispensable
second
cellular
messenger,
calcium
signaling
is
involved
in
regulation
of
almost
all
physiological
processes
by
activating
specific
target
proteins.
The
importance
ions
(Ca
Small,
Journal Year:
2022,
Volume and Issue:
18(25)
Published: May 9, 2022
Heteroatom
doping
can
endow
MXenes
with
various
new
or
improved
electromagnetic,
physicochemical,
optical,
and
structural
properties.
This
greatly
extends
the
arsenal
of
materials
their
potential
for
a
spectrum
applications.
article
comprehensively
critically
discusses
syntheses,
properties,
emerging
applications
growing
family
heteroatom-doped
materials.
First,
strategies,
synthesis
methods,
theoretical
simulations
high-performance
are
summarized.
In
order
to
achieve
materials,
mechanism
atomic
element
from
three
aspects
lattice
optimization,
functional
substitution,
interface
modification
is
analyzed
summarized,
aiming
provide
clues
developing
controllable
synthetic
routes.
The
mechanisms
underlying
advantageous
uses
energy
storage,
catalysis,
sensors,
environmental
purification
biomedicine
highlighted.
Finally,
future
opportunities
challenges
study
application
multifunctional
presented.
work
could
open
up
prospects
development
MXenes.