Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(9), P. 855 - 855

Published: Sept. 9, 2020

Transdermal delivery systems have gained much interest in recent years owing to their advantages compared conventional oral and parenteral systems. They are noninvasive self-administered that can improve patient compliance provide a controlled release of the therapeutic agents. The greatest challenge transdermal is barrier function skin’s outermost layer. Molecules with molecular weights greater than 500 Da ionized compounds generally do not pass through skin. Therefore, only limited number drugs capable being administered by this route. Encapsulating transfersomes one potential approaches overcome problem. bilayered structure facilitates encapsulation lipophilic hydrophilic, as well amphiphilic, drug higher permeation efficiencies liposomes. Transfersomes elastic nature, which deform squeeze themselves an intact vesicle narrow pores significantly smaller its size. This review aims describe concept transfersomes, mechanism action, different methods preparation characterization factors affecting properties along applications administration drugs.

Language: Английский

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A review on recent advances in polymer and peptide hydrogels

Soft Matter, Journal Year: 2020, Volume and Issue: 16(6), P. 1404 - 1454

Published: Jan. 1, 2020

Herein, very recent advances in polymer, peptide, and hybrid hydrogels for uses photovoltaics, supercapacitor, organic electronics, drug delivery, tissue engineering, biosensing, cell culture, different optoelectronic materials are discussed.

Language: Английский

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Recent advances of self-assembling peptide-based hydrogels for biomedical applications

Soft Matter, Journal Year: 2019, Volume and Issue: 15(8), P. 1704 - 1715

Published: Jan. 1, 2019

Peptide-based hydrogels have been proven to be preeminent biomedical materials due their high water content, tunable mechanical stability, great biocompatibility and excellent injectability. The ability of peptide-based provide extracellular matrix-mimicking environments opens up opportunities for applications in fields such as drug delivery, tissue engineering, wound healing. In this review, we first describe several methods commonly used the fabrication robust hydrogels, including spontaneous hydrogelation, enzyme-controlled hydrogelation cross-linking-enhanced hydrogelation. We then introduce some representative studies on delivery antitumor therapy, antimicrobial healing materials, 3D bioprinting engineering. hope that review facilitates advances applications.

Language: Английский

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Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(3), P. 357 - 357

Published: March 8, 2021

The popularity of hydrogels as biomaterials lies in their tunable physical properties, ability to encapsulate small molecules and macromolecular drugs, water holding capacity, flexibility, controllable degradability. Functionalization strategies overcome the deficiencies conventional expand role advanced such DNA are extensively discussed this review. Different types cross-linking techniques, materials utilized, procedures, advantages, disadvantages covering tabulated. application hydrogels, particularly buccal, oral, vaginal, transdermal drug delivery systems, described. review also focuses on composite with enhanced properties that being developed meet diverse demand wound dressing materials. unique advantages hydrogel nanoparticles targeted intracellular various therapeutic agents explained. Furthermore, different hydrogel-based utilized for tissue engineering applications fabrication contact lens discussed. article provides an overview selected examples commercial products launched area oral ocular systems Hydrogels can be prepared a wide variety achieving biostable, bioresorbable, biodegradable polymer matrices, whose mechanical degree swelling tailored specific application. These features give them promising future fields applied biomedicine.

Language: Английский

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Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(42)

Published: Aug. 19, 2020

Abstract Transdermal drug delivery patches based on hydrogels are widely used for the transdermal of diverse drugs. However, most do not exhibit adequate adhesiveness to skin surface. Herein, tissue adhesive consisting polyacrylamide/polydopamine (PAM/PDA) embedded with extra‐large pore mesoporous silica nanoparticles (XL‐MSNs) proposed synergy cohesive and properties. The incorporation XL‐MSNs leads enhanced strength due an increased property derived from molecular interactions between polymer chains. application hydrogel–skin interface a further gluing role interface. optimized condition enables 4.9‐fold increase in adhesion energy porcine tissue, compared control PAM/PDA patch. Strong is achieved immediately after hydrogel patch attached onto as well surfaces other organs. Finally, through demonstrated by using patch, model loaded These observations indicate simple but highly effective strategy preparing delivery.

Language: Английский

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Hydrogel as a Biomaterial for Bone Tissue Engineering: A Review

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(8), P. 1511 - 1511

Published: July 31, 2020

Severe bone damage from diseases, including extensive trauma, fractures, and tumors, cannot self-heal, while traditional surgical treatment may bring side effects such as infection, inflammation, pain. As a new biomaterial with controllable mechanical properties biocompatibility, hydrogel is widely used in tissue engineering (BTE) scaffold for growth factor transport cell adhesion. In order to make more suitable the local of preparation methods should be combined synthetic materials excellent advanced technologies different fields better control drug release time orientation. It necessary establish complete method evaluate hydrogel’s biocompatibility human body. Moreover, establishment standard animal models defects helps studying therapeutic effect hydrogels on repair, well safety suitability hydrogels. Thus, this review aims systematically summarize current studies BTE, mechanisms promoting synthesis, design, preparation; characterization evaluation methods; explore future applications BTE.

Language: Английский

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Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale

International Journal of Pharmaceutics, Journal Year: 2019, Volume and Issue: 573, P. 118817 - 118817

Published: Nov. 2, 2019

Language: Английский

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Advancements in nanoparticle-based treatment approaches for skin cancer therapy

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Jan. 12, 2023

Skin cancer has emerged as the fifth most commonly reported in world, causing a burden on global health and economy. The enormously rising environmental changes, industrialization, genetic modification have further exacerbated skin statistics. Current treatment modalities such surgery, radiotherapy, conventional chemotherapy, targeted therapy, immunotherapy are facing several issues related to cost, toxicity, bioavailability thereby leading declined anti-skin therapeutic efficacy poor patient compliance. In context of overcoming this limitation, nanotechnological advancements been witnessed so far. Among various nanomaterials, nanoparticles endowed exorbitant advantages by acting both agents drug carriers for remarkable cancer. small size large surface area volume ratio escalate tumor uptake through their leaky vasculature resulting enhanced efficacy. context, present review provides up date information about different types pathology cancer, followed current associated drawbacks. Furthermore, it meticulously discusses role numerous inorganic, polymer, lipid-based therapy with subsequent descriptions patents clinical trials.

Language: Английский

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Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

Cancer Cell, Journal Year: 2022, Volume and Issue: 40(10), P. 1207 - 1222.e10

Published: Sept. 8, 2022

Language: Английский

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Engineering Platelet‐Rich Plasma Based Dual‐Network Hydrogel as a Bioactive Wound Dressing with Potential Clinical Translational Value

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 31(8)

Published: Nov. 30, 2020

Abstract Delayed wound healing has a profound impact on patients, healthcare, and society. Platelet‐rich plasma (PRP) gel, as preparation for regenerative medicine, proven to be of clinical value in various treatments. Nevertheless, its weak mechanical properties consequent burst release effect have restricted application efficacy. Here, an engineered PRP dual‐network hydrogel (named DN gel) based sodium alginate is constructed through simple “one‐step” activation process. Its improved gelling property sustained growth factors may beneficial use. Evaluations rats indicate that gel promote terms rapid re‐epithelialization, up‐regulated factor levels early transitions the angiogenesis stages. As proof concept, also exhibits superior efficiency porcine model. These results demonstrate great potential transforming this into next generation PRP‐based bioactive dressing.

Language: Английский

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