Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(35)
Published: May 26, 2023
Cationic
photosensitizers
have
good
binding
ability
with
negatively
charged
bacteria
and
fungi,
exhibiting
broad
applications
potential
in
antimicrobial
photodynamic
therapy
(aPDT).
However,
cationic
often
display
unsatisfactory
transkingdom
selectivity
between
mammalian
cells
pathogens,
especially
for
eukaryotic
fungi.
It
is
unclear
which
biomolecular
sites
are
more
efficient
damage,
owing
to
the
lack
of
systematic
research
same
photosensitizer
system.
Herein,
a
series
aggregation-induced
emission
(AIE)
derivatives
(CABs)
(using
berberine
(BBR)
as
core)
different
length
alkyl
chains
successfully
designed
synthesized
flexible
modulation
cellular
activities.
The
BBR
core
can
efficiently
produce
reactive
oxygen
species
(ROS)
achieve
high-performance
aPDT
.
Through
precise
regulation
chain
length,
bindings,
localizations,
killing
effects
CABs
achieved
investigated
systematically
among
bacteria,
cells.
found
that
intracellular
active
substances,
not
membranes,
damage
aPDT.
Moderate
enable
effectively
kill
Gram-negative
fungi
light,
while
still
maintaining
excellent
cell
blood
compatibility.
This
study
expected
provide
theoretical
strategic
guidance
construction
selectivity.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(30), P. 34455 - 34469
Published: July 20, 2022
Engineered
wound
dressing
materials
with
excellent
injectability,
self-healing
ability,
tissue-adhesiveness,
especially
the
ones
possessing
potential
therapeutic
effects
have
great
practical
significance
in
healthcare.
Herein,
an
injectable
quaternary
ammonium
chitosan
(QCS)/tannic
acid
(TA)
hydrogel
based
on
QCS
and
TA
was
designed
fabricated
by
facile
mixing
of
two
ingredients
under
physiological
conditions.
In
this
system,
hydrogels
were
mainly
cross-linked
dynamic
ionic
bonds
hydrogen
between
TA,
which
endows
injectable,
self-healing,
adhesive
properties.
Benefitting
from
inherent
antioxidative,
antibacterial,
hemostatic
abilities
QCS,
showed
superior
reactive
oxygen
species
scavenging
activity,
broad-spectrum
antibacterial
as
well
rapid
capability.
Moreover,
QCS/TA2.5
(containing
2.5%
TA)
exhibited
biocompatibility.
The
vivo
experiments
also
that
not
only
rapidly
stopped
bleeding
arterial
deep
incompressible
wounds
mouse
tail
amputation,
femoral
artery
hemorrhage,
liver
incision
models
but
significantly
accelerated
healing
a
full-thickness
skin
model.
For
potentials
listed
above,
multifunctional
offers
promising
network
material
for
both
hemostasis
repair.
Advanced Science,
Journal Year:
2021,
Volume and Issue:
8(20)
Published: Aug. 19, 2021
The
efficacy
of
cardiac
regenerative
strategies
for
myocardial
infarction
(MI)
treatment
is
greatly
limited
by
the
microenvironment.
combination
reactive
oxygen
species
(ROS)
scavenging
to
suppress
oxidative
stress
damage
and
macrophage
polarization
M2
phenotype
in
MI
microenvironment
can
be
desirable
treatment.
Herein,
melanin
nanoparticles
(MNPs)/alginate
(Alg)
hydrogels
composed
two
marine-derived
natural
biomaterials,
MNPs
obtained
from
cuttlefish
ink
alginate
extracted
ocean
algae,
are
proposed.
Taking
advantage
antioxidant
property
mechanical
support
injectable
hydrogels,
MNPs/Alg
hydrogel
explored
repair
regulating
found
eliminate
ROS
against
injury
cardiomyocytes.
More
interestingly,
macrophages
promoted
presence
hydrogel.
An
rat
model
utilized
evaluate
feasibility
as-prepared
vivo.
antioxidant,
anti-inflammatory,
proangiogenesis
effects
investigated
detail.
present
study
opens
up
a
new
way
utilize
biomaterials
allows
rerecognize
great
value
repair.
Science Advances,
Journal Year:
2022,
Volume and Issue:
8(27)
Published: July 8, 2022
The
treatment
of
difficult-to-heal
wounds
remains
a
substantial
clinical
challenge
due
to
deteriorative
tissue
microenvironment
including
the
loss
extracellular
matrix
(ECM),
excessive
inflammation,
impaired
angiogenesis,
and
bacterial
infection.
Inspired
by
chemical
components,
fibrous
structure,
biological
function
natural
ECM,
antibacterial
environment-responsive
glycopeptide
hybrid
hydrogel
was
developed
for
chronic
wound
healing.
can
facilitate
cell
proliferation
macrophage
polarization
M2
phenotype,
show
potent
efficacy
against
both
Gram-negative
Gram-positive
bacteria.
Significantly,
accelerated
reconstruction
methicillin-resistant
Staphylococcus
aureus
(MRSA)-infected
full-thickness
diabetic
scalding
skin
orchestrating
pro-regenerative
response
indicated
abundant
M2-type
macrophages,
attenuated
promoted
angiogenesis.
Collectively,
ECM-mimetic
immunomodulatory
is
promising
multifunctional
dressing
reshape
damaged
environment
without
additional
drugs,
exogenous
cytokines,
or
cells,
providing
an
effective
strategy
repair
regeneration
cutaneous
wounds.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(5)
Published: April 3, 2023
Growth
factors
play
a
crucial
role
in
regulating
broad
variety
of
biological
processes
and
are
regarded
as
powerful
therapeutic
agents
tissue
engineering
regenerative
medicine
the
past
decades.
However,
their
application
is
limited
by
short
half-lives
potential
side
effects
physiological
environments.
Hydrogels
identified
having
promising
to
prolong
growth
mitigate
adverse
restricting
them
within
matrix
reduce
rapid
proteolysis,
burst
release,
unwanted
diffusion.
This
review
discusses
recent
progress
development
factor-containing
hydrogels
for
various
biomedical
applications,
including
wound
healing,
brain
repair,
cartilage
bone
regeneration,
spinal
cord
injury
repair.
In
addition,
introduces
strategies
optimizing
factor
release
affinity-based
delivery,
carrier-assisted
stimuli-responsive
spatial
structure-based
cellular
system-based
delivery.
Finally,
presents
current
limitations
future
research
directions
factor-delivering
hydrogels.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(13)
Published: March 2, 2023
Abstract
Macrophages
are
highly
heterogeneous
and
exhibit
a
diversity
of
functions
phenotypes.
They
can
be
divided
into
pro‐inflammatory
macrophages
(M1)
anti‐inflammatory
(M2).
Diabetic
wounds
characterized
by
prolonged
inflammatory
phase
difficulty
in
healing
due
to
the
accumulation
wound.
Therefore,
hydrogel
dressings
with
macrophage
heterogeneity
regulation
function
hold
great
promise
promoting
diabetic
wound
clinical
applications.
However,
precise
conversion
M1
M2
simple
biosafe
approaches
is
still
challenge.
Here,
an
all‐natural
ability
regulate
developed
promote
angiogenesis
healing.
The
protocatechuic
aldehyde
hybridized
collagen‐based
exhibits
good
bioadhesive
antibacterial
properties
as
well
reactive
oxygen
species
scavenging
ability.
More
importantly,
able
convert
without
need
for
any
additional
ingredients
or
external
intervention.
This
safe
immunomodulatory
approach
shows
application
potential
shortening
repair
accelerating
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(7), P. 11346 - 11359
Published: July 18, 2022
The
development
of
natural
hydrogels
with
sufficient
strength
and
self-healing
capacity
to
accelerate
skin
wound
healing
is
still
challenging.
Herein,
a
hyaluronic
acid
nanocomposite
hydrogel
was
developed
based
on
aldehyde-modified
sodium
hyaluronate
(AHA),
hydrazide-modified
(ADA),
cellulose
nanocrystals
(oxi-CNC).
This
formed
in
situ
using
dynamic
acylhydrazone
bonds
via
double-barreled
syringe.
exhibited
improved
excellent
ability.
Furthermore,
platelet-rich
plasma
(PRP)
can
be
loaded
the
(ADAC)
imine
between
amino
groups
PRP
(e.g.,
fibrinogen)
aldehyde
AHA
or
oxi-CNC
promote
synergistically.
As
expected,
ADAC
could
protect
release
sustainably.
In
animal
experiments,
ADAC@PRP
significantly
promoted
full-thickness
through
enhancing
formation
granulation
tissue,
facilitating
collagen
deposition,
accelerating
re-epithelialization
neovascularization.
loading
appears
promising
candidate
for
therapy.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(5), P. 5068 - 5143
Published: Dec. 28, 2021
Recent
advances
in
nanostructured
materials
and
unconventional
device
designs
have
transformed
the
bioelectronics
from
a
rigid
bulky
form
into
soft
ultrathin
brought
enormous
advantages
to
bioelectronics.
For
example,
mechanical
deformability
of
thus
its
conformal
contact
onto
curved
organs
such
as
brain,
heart,
skin
allowed
researchers
measure
high-quality
biosignals,
deliver
real-time
feedback
treatments,
lower
long-term
side-effects
vivo.
Here,
we
review
various
materials,
fabrication
methods,
strategies
for
flexible
stretchable
electronics,
especially
focusing
on
biointegrated
electronics
using
nanomaterials
their
composites.
First,
summarize
top-down
material
processing
bottom-up
synthesis
methods
nanomaterials.
Next,
discuss
state-of-the-art
technologies
intrinsically
nanocomposites
composed
incorporated
elastomers
or
hydrogels.
We
also
briefly
design
Then
individual
components
bioelectronics,
biosensing,
data
storage,
display,
therapeutic
stimulation,
power
supply
devices,
are
introduced.
Afterward,
representative
application
examples
described.
A
brief
summary
with
discussion
remaining
challenges
concludes
review.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
19, P. 360 - 375
Published: April 26, 2022
The
high
demand
for
rapid
wound
healing
has
spurred
the
development
of
multifunctional
and
smart
bioadhesives
with
strong
bioadhesion,
antibacterial
effect,
real-time
sensing,
wireless
communication,
on-demand
treatment
capabilities.
Bioadhesives
bio-inspired
structures
chemicals
have
shown
unprecedented
adhesion
strengths,
as
well
tunable
optical,
electrical,
bio-dissolvable
properties.
Accelerated
been
achieved
via
directly
released
growth
factors,
material
or
drug-induced
host
immune
responses,
delivery
curative
cells.
Most
recently,
integration
biosensing
modules
units
in
a
closed-loop
system
yielded
bioadhesives,
allowing
sensing
physiological
conditions
(e.g.,
pH,
temperature,
uric
acid,
glucose,
cytokine)
iterative
feedback
drastically
enhanced,
stage-specific
by
triggering
drug
to
avoid
infection
prolonged
inflammation.
Despite
advances
burgeoning
field,
challenges
still
exist
design
fabrication
integrated
systems,
particularly
chronic
wounds,
presenting
significant
opportunities
future
next-generation
materials
systems.
