Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors

Biomaterials, Journal Year: 2020, Volume and Issue: 268, P. 120537 - 120537

Published: Nov. 17, 2020

Language: Английский

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Recent progress in ferroptosis: inducers and inhibitors

Cell Death Discovery, Journal Year: 2022, Volume and Issue: 8(1)

Published: Dec. 29, 2022

Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous interest in disease treatment research communities pursuit to reveal the mechanism key targets because closely related pathophysiological processes many diseases. Recent studies have shown some targets, such as glutathione peroxidase 4 (GPX4) System Xc-, several inducers inhibitors been developed regulate these targets. With emergence on made developments. The selection use are very important for work. This paper briefly introduces regulatory metabolic pathway, lists categorizes commonly used recently inhibitors, discusses their medical application. ends with potential future direction ferroptosis.

Language: Английский

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Ferroptosis-driven nanotherapeutics for cancer treatment

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 319, P. 322 - 332

Published: Jan. 7, 2020

Language: Английский

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Expandable Immunotherapeutic Nanoplatforms Engineered from Cytomembranes of Hybrid Cells Derived from Cancer and Dendritic Cells

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(18)

Published: March 25, 2019

Using the cytomembranes (FMs) of hybrid cells acquired from fusion cancer and dendritic (DCs), this study offers a biologically derived platform for combination immunotherapy traditional oncotherapy approaches. Due to immunoactivation implicated in cellular fusion, FMs can effectively express whole antigens immunological co-stimulatory molecules robust immunotherapy. share tumor's self-targeting character with parent cells. In bilateral tumor-bearing mouse models, FM-coated nanophotosensitizer causes durable immunoresponse inhibit rebound primary tumors post-nanophotosensitizer-induced photodynamic therapy (PDT). The FM-induced displays ultrahigh antitumor effects even comparable that PDT. On other hand, PDT toward enhances immunotherapy-caused regression irradiation-free distant tumors. Consequently, both are almost completely eliminated. This tumor-specific immunotherapy-based nanoplatform is potentially expandable multiple tumor types readily equipped diverse functions owing flexible nanoparticle options.

Language: Английский

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Which cell death modality wins the contest for photodynamic therapy of cancer?

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(5)

Published: May 13, 2022

Abstract Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed the treatment of several types cancer. Traditionally, cell death induced by categorized into three types: apoptosis, associated with autophagy, necrosis. However, discovery other regulated modalities in recent years, it has become clear that this is a rather simple understanding mechanisms action PDT. New observations revealed cancer cells exposed to can pass through various non-conventional pathways, such as paraptosis, parthanatos, mitotic catastrophe, pyroptosis, necroptosis, ferroptosis. Nowadays, immunogenic (ICD) one most promising ways eradicate tumor activation T-cell adaptive immune response induction long-term immunological memory. ICD be triggered anti-cancer methods, including In review, we critically discuss findings on Next, emphasize role contribution these PDT-induced modalities. Finally, obstacles propose areas research will help overcome challenges lead development highly effective based

Language: Английский

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