Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors DOI Creative Commons
Elena Catanzaro, Manuel Beltrán‐Visiedo, Lorenzo Galluzzi

et al.

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

While immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the clinical management of various malignancies, a large fraction patients are refractory to ICIs employed as standalone therapeutics, necessitating development combinatorial treatment strategies. Immunogenic cell death (ICD) inducers have attracted considerable interest partners for ICIs, at least in part owing their ability initiate tumor-targeting adaptive response. However, compared either approach alone, regimens involving ICD and not always shown superior activity. Here, we discuss accumulating evidence on therapeutic interactions between oncological settings, identify key factors that may explain discrepancies preclinical findings, propose strategies address existing challenges increase efficacy these combinations cancer.

Language: Английский

Engineering of BODIPY-based theranostics for cancer therapy DOI
Zhiqiang Mao, Ji Hyeon Kim, Jieun Lee

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

Citations

101
Enzyme-Responsive Double-Locked Photodynamic Molecular Beacon for Targeted Photodynamic Anticancer Therapy DOI Creative Commons
Leo K. B. Tam, Jacky C. H. Chu,

Lin He

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(13), P. 7361 - 7375

Published: March 24, 2023

An advanced photodynamic molecular beacon (PMB) was designed and synthesized, in which a distyryl boron dipyrromethene (DSBDP)-based photosensitizer Black Hole Quencher 3 moiety were connected via two peptide segments containing the sequences PLGVR GFLG, respectively, of cyclic peptide. These short are well-known substrates matrix metalloproteinase-2 (MMP-2) cathepsin B, both overexpressed wide range cancer cells either extracellularly (for MMP-2) or intracellularly B). Owing to efficient Förster resonance energy transfer between components, this PMB fully quenched native form. Only upon interaction with MMP-2 buffer solution cells, cleaved specifically, components could be completely separated, thereby restoring activities DSBDP moiety. This also activated tumors, it effectively suppressed tumor growth A549 tumor-bearing nude mice laser irradiation without causing notable side effects. In particular, did not cause skin photosensitivity, is very common effect therapy (PDT) using conventional "always-on" photosensitizers. The overall results showed that "double-locked" functioned as biological AND logic gate only unlocked by coexistence tumor-associated enzymes, greatly enhance specificity PDT.

Language: Английский

Citations

71
Paraptosis: a unique cell death mode for targeting cancer DOI Creative Commons

Sweata Hanson,

Aiswarya Dharan,

P. V. Jinsha

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 15, 2023

Programmed cell death (PCD) is the universal process that maintains cellular homeostasis and regulates all living systems' development, health disease. Out of all, apoptosis one major PCDs was found to play a crucial role in many disease conditions, including cancer. The cancer cells acquire ability escape apoptotic death, thereby increasing their resistance towards current therapies. This issue has led need search for alternate forms programmed mechanisms. Paraptosis an alternative pathway characterized by vacuolation damage endoplasmic reticulum mitochondria. Many natural compounds metallic complexes have been reported induce paraptosis lines. Since morphological biochemical features are much different from other PCDs, it understand modulators governing it. In this review, we highlighted factors trigger specific mediating pathway. Recent findings include inducing anti-tumour T-cell immunity immunogenic responses against A significant played also scaled its importance knowing mechanism. study xenograft mice, zebrafish model, 3D cultures, novel paraptosis-based prognostic model low-grade glioma patients broad aspect potential involvement field therapy. co-occurrence modes with photodynamic therapy combinatorial treatments tumour microenvironment summarized here. Finally, growth, challenges, future perspectives research discussed review. Understanding unique PCD would help develop combat chemo-resistance various

Language: Английский

Citations

55
Different types of cell death and their shift in shaping disease DOI Creative Commons

Sikou Shen,

Yina Shao,

Chenghua Li

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Aug. 4, 2023

Abstract Cell death is the irreversible stop of life. It also basic physiological process all organisms which involved in embryonic development, organ maintenance and autoimmunity body. In recent years, we have gained more comprehension mechanism cell basically clarified different types "programmed death", such as apoptosis, necroptosis, autophagy, pyroptosis, identified some key genes these processes. However, previous studies, conversion between modes their application diseases are rarely explored. To sum up, although many valued discoveries been discovered field there still unknown problems to be solved this field. Facts proved that a very complex game, series core players ability destroy delicate balance environment, from survival death, anti-inflammatory pro-inflammatory. With thorough research regulatory will certainly exciting new next few years. The sake paper emphasize overturning fates provide relevant theoretical basis for connection transformation disease treatment future.

Language: Английский

Citations

55
Trial watch: chemotherapy-induced immunogenic cell death in oncology DOI Creative Commons
Jenny Sprooten, Raquel S. Laureano, Isaure Vanmeerbeek

et al.

OncoImmunology, Journal Year: 2023, Volume and Issue: 12(1)

Published: June 3, 2023

Immunogenic cell death (ICD) refers to an immunologically distinct process of regulated that activates, rather than suppresses, innate and adaptive immune responses. Such responses culminate into T cell-driven immunity against antigens derived from dying cancer cells. The potency ICD is dependent on the immunogenicity cells as defined by antigenicity these their ability expose immunostimulatory molecules like damage-associated molecular patterns (DAMPs) cytokines type I interferons (IFNs). Moreover, it crucial host’s system can adequately detect adjuvanticity Over years, several well-known chemotherapies have been validated potent inducers, including (but not limited to) anthracyclines, paclitaxels, oxaliplatin. ICD-inducing chemotherapeutic drugs serve important combinatorial partners for anti-cancer immunotherapies highly immuno-resistant tumors. In this Trial Watch, we describe current trends in preclinical clinical integration chemotherapy existing immuno-oncological paradigms.

Language: Английский

Citations

43
Nanoplatform-enhanced photodynamic therapy for the induction of immunogenic cell death DOI
Xu Liu,

Yichao Lu,

Xiang Li

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 365, P. 1058 - 1073

Published: Jan. 1, 2024

Language: Английский

Citations

27
Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer DOI Creative Commons
Yun Zhou, Wenyao Zhang,

Boda Wang

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2024, Volume and Issue: 12(3), P. e008054 - e008054

Published: March 1, 2024

Background The effectiveness of immune checkpoint inhibitors in colorectal cancer (CRC) is limited due to the low tumor neoantigen load and infiltration most microsatellite-stable (MSS) tumors. This study aimed develop a mitochondria-targeted photodynamic therapy (PDT) approach provoke host antitumor immunity MSS-CRC elucidate underlying molecular mechanisms. Methods role mechanism PDT inhibiting CRC progression inducing pyroptosis were evaluated both vitro vivo. effects sensitization on PD-1 blockade also assessed CT26 4T1 tumor-bearing mouse models. Results Here, we report that using IR700DX-6T, photosensitizer targeting mitochondrial translocation protein, may trigger an response initiated by CRC. Mechanistically, IR700DX-6T-PDT produced reactive oxygen species light irradiation promoted downstream p38 phosphorylation active caspase3 (CASP3)-mediated cleavage gasdermin E (GSDME), subsequently pyroptosis. Furthermore, enhanced sensitivity cells blockade. Decitabine, demethylation drug used treat hematologic neoplasms, disrupted abnormal methylation pattern GSDME cells, efficacy IR700DX-6T-PDT, elicited potent combination with IR700DX-6T-PDT. Conclusion Our work provides clear understanding immunogenic cell death triggered PDT, offering new for enhancing

Language: Английский

Citations

20
Zero-dimensional nano-carbons: Synthesis, properties, and applications DOI
Darwin Kurniawan, Zhenhai Xia, Liming Dai

et al.

Applied Physics Reviews, Journal Year: 2024, Volume and Issue: 11(2)

Published: April 19, 2024

Zero-dimensional (0D) nano-carbons, including graphene quantum dots, nanodiamonds, and carbon represent the new generation of carbon-based nanomaterials with exceptional properties arising from diverse phenomena, such as surface, size, edge effects, which strongly depend on carbon–carbon bond configuration (sp2, sp3, a mixture sp2 sp3) particle size. Their unique physicochemical properties, optical, electronic, magnetic, reactivity, catalytic are valuable for energy conversion storage, sensing, catalysis, optoelectronic devices, modern nanotechnologies, biomedical, many other applications. This review aims to provide insights into distinctive effects 0D nano-carbon microstructures their that crucial cutting-edge fundamental studies broad range multifunctional The key synthesis methods different types nano-carbons current advances characterization computational techniques study structures structure–property relationships also discussed. concludes status, challenges, future opportunities in this rapidly developing research field.

Language: Английский

Citations

19
Near-infrared-driven upconversion nanoparticles with photocatalysts through water-splitting towards cancer treatment DOI
Pranjyan Dash, Pradeep Kumar Panda,

Chaochin Su

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(16), P. 3881 - 3907

Published: Jan. 1, 2024

Water splitting is promising, especially for energy and environmental applications; however, there are limited studies on the link between water cancer treatment. Upconversion nanoparticles (UCNPs) can be used to convert near-infrared (NIR) light ultraviolet (UV) or visible (Vis) have great potential biomedical applications because of their profound penetration ability, theranostic approaches, low self-fluorescence background, reduced damage biological tissue, toxicity. UCNPs with photocatalytic materials enhance activities that generate a shorter wavelength increase tissue depth in microenvironment under NIR irradiation. Moreover, photosensitizer absorb it into UV/vis emit upconverted photons, which excite photoinitiator create H

Language: Английский

Citations

17
Cell death: The underlying mechanisms of photodynamic therapy for skin diseases DOI Creative Commons

H.Y. Li,

Jingjie Shen,

Chunfu Zheng

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Photodynamic therapy (PDT) has significant potential in the treatment of dermatological, oncological, and nonneoplastic conditions through induction cell death, immune regulation, antimicrobial effects, etc. However, response some patients is unsatisfactory, there a lack an ideal protocol for multiple specific diseases (subtypes) to choose proper photosensitizer (PS), light source, dose. A thorough understanding underlying mechanism integral solving these problems, death gained much attention. In addition apoptosis, autophagy, necrosis, several novel pathways, such as necroptosis, mitotic catastrophe, paraptosis pyroptosis, have been reported PDT treatment. The type induced depends on dose PDT, subcellular location PSs, regulation signaling pathways. addition, different types by same apoptosis may interact with each other. Some can also trigger immunogenic (ICD), which ignite against antigens derived from dying/dead cells present improved antitumor effects. On basis mechanisms, strategies, targeted combined immunotherapy ICD‐based vaccines, proposed improve therapeutic efficacy. Future studies are needed elucidate relationship between effects shed new exploration precise patients.

Language: Английский

Citations

2