Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(1), P. 23 - 36

Published: Aug. 19, 2020

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Thermal Atomization of Platinum Nanoparticles into Single Atoms: An Effective Strategy for Engineering High-Performance Nanozymes

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(44), P. 18643 - 18651

Published: Nov. 2, 2021

Although great progress has been made in artificial enzyme engineering, their catalytic performance is far from satisfactory as alternatives of natural enzymes. Here, we report a novel and efficient strategy to access high-performance nanozymes via direct atomization platinum nanoparticles (Pt NPs) into single atoms by reversing the thermal sintering process. Atomization Pt NPs makes metal sites fully exposed results engineerable structural electronic properties, thereby leading dramatically enhanced enzymatic performance. As expected, as-prepared thermally stable single-atom nanozyme (PtTS-SAzyme) exhibited remarkable peroxidase-like activity kinetics, exceeding nanoparticle nanozyme. The following density functional theory calculations revealed that engineered P S not only promote process PtTS-SAzyme but also endow with unique structure owing electron donation atoms, well acceptance N which simultaneously contribute substantial enhancement enzyme-like PtTS-SAzyme. This work demonstrates nanoparticle-based an effective for engineering nanozymes, opens up new way rationally design optimize enzymes mimic

Language: Английский

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An overview of the use of nanozymes in antibacterial applications

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 418, P. 129431 - 129431

Published: March 21, 2021

Language: Английский

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Nanoparticles for Oral Biofilm Treatments

ACS Nano, Journal Year: 2019, Volume and Issue: 13(5), P. 4869 - 4875

Published: April 29, 2019

Pathogenic oral biofilms are universal, chronic, and costly. Despite advances in understanding the mechanisms of biofilm formation persistence, novel effective treatment options remain scarce. Nanoparticle-mediated eradication matrix resident bacteria holds great potential. In particular, nanoparticles that target specific microbial features utilizing nontoxic materials well-suited for clinical translation. However, much work remains to characterize local systemic effects therapeutic agents topically applied chronic biofilms, such as those cause dental caries. this Perspective, we summarize pathogenesis describe current future nanoparticle-mediated approaches, highlight outstanding questions paramount answer effectively targeting treating biofilms.

Language: Английский

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Infection microenvironment-related antibacterial nanotherapeutic strategies

Biomaterials, Journal Year: 2021, Volume and Issue: 280, P. 121249 - 121249

Published: Nov. 11, 2021

Language: Английский

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Copper Clusters: An Effective Antibacterial for Eradicating Multidrug‐Resistant Bacterial Infection In Vitro and In Vivo

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(14)

Published: Jan. 29, 2021

Abstract Infections caused by multidrug‐resistant (MDR) bacteria pose a threat to human health worldwide, making new effective antibacterial agents urgently desired. To date, it is still great challenge develop antibiotics for MDR with clear mechanisms. Herein, novel alternative copper clusters (CuCs) molecule precisely synthesized utilizing an artificially designed theanine peptide. The prepared CuCs exhibit excellent broad‐spectrum activity in vitro, including gram‐positive (methicillin‐resistant Staphylococcus aureus [MRSA], aureus, and epidermidis ) gram‐negative ( Escherichia coli Pseudomonas aeruginosa ). robust effect due its ability not only destroy the bacterial wall structure, but also regulate ratio of GSH/GSSG inhibiting glutathione reductase, thus causing outbreak reactive oxygen species ultimately leading death. In addition, vivo studies demonstrate that can significantly rescue skin wound infections sepsis mice MRSA, has same therapeutic efficacy as mupirocin ointment first‐line clinically anchored anti‐MRSA drug vancomycin. Moreover, extremely low cytotoxicity normal mammalian cells compared silver platinum clusters. With further development optimization, potential class fight antibiotic‐resistant pathogens.

Language: Английский

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Space-Selective Chemodynamic Therapy of CuFe₅O₈ Nanocubes for Implant-Related Infections

ACS Nano, Journal Year: 2020, Volume and Issue: 14(10), P. 13391 - 13405

Published: Sept. 15, 2020

Implant-related infections (IRIs) are a serious complication after orthopedic surgery, especially when biofilm develops and establishes physical chemical barriers protecting bacteria from antibiotics the hosts local immune system. Effectively eliminating biofilms is essential but difficult, as it requires not only breaking barrier also changing that induces an immunosuppressive microenvironment. Herein, tailored to microenvironment (BME), we proposed space-selective chemodynamic therapy (CDT) strategy combat IRIs using metastable CuFe5O8 nanocubes (NCs) smart Fenton-like reaction catalysts whose activity can be regulated by pH H2O2 concentration. In biofilm, extracellular DNA (eDNA) was cleaved high levels of hydroxyl radicals (•OH) catalyzed NCs, thereby disrupting rigid biofilm. Outside with relatively higher lower concentration, generated •OH effectively reversed inducing pro-inflammatory macrophage polarization. Biofilm fragments exposed were then persistently eliminated through collaboration immunity •OH. The spatially selective activation CDT synergistic immunomodulation exerted excellent effects on treatment in vitro vivo. anti-infection expected provide method conquer IRIs.

Language: Английский

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Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications

Clinical Oral Investigations, Journal Year: 2020, Volume and Issue: 24(12), P. 4237 - 4260

Published: Oct. 27, 2020

Abstract Background All soft and solid surface structures in the oral cavity are covered by acquired pellicle followed bacterial colonization. This applies for natural as well restorative or prosthetic materials; adherent biofilm is associated among others with development of caries, periodontal diseases, peri-implantitis, denture-associated stomatitis. Accordingly, there a considerable demand novel materials coatings that limit modulate attachment and/or propagation microorganisms. Objectives findings The present paper depicts current knowledge on impact different physicochemical characteristics bioadsorption cavity. Furthermore, it was carved out which strategies were developed dental research general science to inhibit colonization delay formation low-fouling “easy-to-clean” surfaces. These include modulation properties such periodic topographies, roughness, free energy, hardness. In recent years, large emphasis laid micro- nanostructured surfaces liquid repellent superhydrophic superhydrophilic interfaces. Materials incorporating mobile bound nanoparticles promoting bacteriostatic bacteriotoxic also used. Recently, chemically textured interfaces gained increasing interest could represent promising solutions innovative antibioadhesion Due unique conditions cavity, mainly vivo situ studies considered review. Conclusion Despite many approaches ubiquitous phenomenon adhesion challenging milieu masks therewith hampers strategies. Clinical relevance Improved easy-to-clean have potential improve health, but extensive systematic required this field develop biocompatible effective substances.

Language: Английский

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Repurposing ferumoxytol: Diagnostic and therapeutic applications of an FDA-approved nanoparticle

Theranostics, Journal Year: 2021, Volume and Issue: 12(2), P. 796 - 816

Published: Dec. 15, 2021

Ferumoxytol is an intravenous iron oxide nanoparticle formulation that has been approved by the U.S. Food and Drug Administration (FDA) for treating anemia in patients with chronic kidney disease. In recent years, ferumoxytol also demonstrated to have potential many additional biomedical applications due its excellent inherent physical properties, such as superparamagnetism, biocatalytic activity, immunomodulatory behavior. With good safety clearance profiles, extensively utilized both preclinical clinical studies. Here, we first introduce medical needs value of current formulations market. We then focus on nanoparticles their physicochemical, diagnostic, therapeutic properties. include examples describing use various applications, including magnetic resonance imaging (MRI), multimodality imaging, deficiency treatment, immunotherapy, microbial biofilm treatment drug delivery. Finally, provide a brief conclusion offer our perspectives limitations emerging biomedicine. Overall, this review provides comprehensive summary developments agent therapeutic, theranostic functionalities.

Language: Английский

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