Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window DOI Creative Commons

Xunzhi Wu,

Yongkuan Suo,

Hui Shi

et al.

Nano-Micro Letters, Journal Year: 2020, Volume and Issue: 12(1)

Published: Jan. 24, 2020

Abstract Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, second (NIR-II; 1000–1700 especially NIR-IIa (1300–1400 is considered much more promising diagnosis superiority penetration depth maximum permissible exposure over NIR-I window. Hereby, we propose use laser excitation at 1275 nm, which approved by Food Drug Administration physical therapy, an attractive technique to balance tissue absorption scattering with water absorption. Specifically, CuS-PEG nanoparticles similar values 808 a conventional PTT, were synthesized agents comparison platform, explore potential nm deep-tissue settings. results showed that was practicable PTT. It exhibited desirable outcomes cell ablation vitro antitumor capabilities vivo compared laser. illumination superior shows high improve outcome.

Language: Английский

Progress in ATRP-derived materials for biomedical applications DOI Creative Commons
Mohsen Khodadadi Yazdi,

Payam Zarrintaj,

Mohammad Reza Saeb

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 143, P. 101248 - 101248

Published: Feb. 11, 2024

Language: Английский

Citations

19
NIR-II-excited off-on-off fluorescent nanoprobes for sensitive molecular imaging in vivo DOI Creative Commons
Yufu Tang, Yuanyuan Li,

Chunxu He

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Strong background interference signals from normal tissues have significantly compromised the sensitive fluorescence imaging of early disease with exogenous probes in vivo, particularly for liver due to liver's significant uptake and accumulation nanoprobes, coupled high tissue autofluorescence deep depth. As a proof-of-concept study, we herein report near-infrared-II (NIR-II, 1.0-1.7 μm) light-excited "off-on-off" NIR-II fluorescent probe (NDP). It has near-ideal zero initial but can turn on its cancer then off again upon migration minimize interference. Due low background, blind study employing our could identify female mice orthotopic tumors 100% accuracy mixed subjects healthy tumor mice, implemented locating sizes as small 4 mm. Our NIR-II-excited design concept not only provides promising molecular guideline also be generalized other lesions. Background compromise vivo. Here, authors Near-infrared-II excited ''off-on-off" focus events occurring diffusion activated tumors.

Language: Английский

Citations

2
Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer DOI Creative Commons
Le Tang, Xiao Yang, Liwen He

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 31, 2025

Language: Английский

Citations

2
Renal clearable Hafnium-doped carbon dots for CT/Fluorescence imaging of orthotopic liver cancer DOI
Ya Su, Shi Liu,

Yuyao Guan

et al.

Biomaterials, Journal Year: 2020, Volume and Issue: 255, P. 120110 - 120110

Published: June 8, 2020

Language: Английский

Citations

110
Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window DOI Creative Commons

Xunzhi Wu,

Yongkuan Suo,

Hui Shi

et al.

Nano-Micro Letters, Journal Year: 2020, Volume and Issue: 12(1)

Published: Jan. 24, 2020

Abstract Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, second (NIR-II; 1000–1700 especially NIR-IIa (1300–1400 is considered much more promising diagnosis superiority penetration depth maximum permissible exposure over NIR-I window. Hereby, we propose use laser excitation at 1275 nm, which approved by Food Drug Administration physical therapy, an attractive technique to balance tissue absorption scattering with water absorption. Specifically, CuS-PEG nanoparticles similar values 808 a conventional PTT, were synthesized agents comparison platform, explore potential nm deep-tissue settings. results showed that was practicable PTT. It exhibited desirable outcomes cell ablation vitro antitumor capabilities vivo compared laser. illumination superior shows high improve outcome.

Language: Английский

Citations

105