Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 169 - 184
Published: June 24, 2023
Language: Английский
Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(52), P. 21730 - 21742
Published: Dec. 14, 2020
Microglia as an important type of innate immune cell in the brain have been considered effective therapeutic target for treatment central nervous degenerative diseases. Herein, we report membrane coated novel biomimetic Cu2–xSe-PVP-Qe nanoparticles (denoted CSPQ@CM nanoparticles, where PVP is poly(vinylpyrrolidone), Qe quercetin, and CM neuron cells) effectively targeting modulating microglia to treat Parkinson's disease (PD). The CSPQ exhibit multienzyme activities could scavenge reactive oxygen species promote polarization into anti-inflammatory M2-like phenotype relieve neuroinflammation. We reveal that targeted through specific interactions between surface vascular cells adhering molecule-1 α4β1 integrin expressed by microglia. They significantly improve symptoms PD mice result excellent efficacy, evidenced recovery their dopamine level cerebrospinal fluid, tyrosine hydroxylase, ionized calcium binding adapter protein 1 normal levels. Our work demonstrates great potential these robust other
Language: Английский
Citations
150
Small Structures, Journal Year: 2020, Volume and Issue: 1(1)
Published: Sept. 9, 2020
Platelets possess distinct surface moieties responsible for modulating their adhesion to various disease-relevant substrates involving vascular damage, immune evasion, and pathogen interactions. Such broad biointerfacing capabilities of platelets have inspired the development platelet-mimicking drug carriers that preferentially target payloads disease sites enhanced therapeutic efficacy. Among these carriers, platelet membrane-coated nanoparticles (denoted 'PNPs') made by cloaking synthetic with plasma membrane emerged recently. Their 'top-down' design combines functionalities natural engineering flexibility nanomaterials, which together create synergy effective delivery novel therapeutics. Herein, we review recent progress PNPs different structures targeted delivery, focusing on three areas, including targeting injured blood vessels treat diseases, cancer cells treatment detection, drug-resistant bacteria infectious diseases. Overall, current studies established as versatile nanotherapeutics strong potentials improve
Language: Английский
Citations
148
Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 945 - 985
Published: Nov. 23, 2020
Cell primitive-based functional materials that combine the advantages of natural substances and nanotechnology have emerged as attractive therapeutic agents for cancer therapy. primitives are characterized by distinctive biological functions, such long-term circulation, tumor specific targeting, immune modulation etc. Moreover, synthetic nanomaterials featuring unique physical/chemical properties been widely used effective drug delivery vehicles or anticancer to treat cancer. The combination these two kinds will catalyze generation innovative biomaterials with multiple high biocompatibility negligible immunogenicity precise In this review, we summarize most recent advances in development cell Different primitives, including bacteria, phages, cells, membranes, other bioactive introduced their strategies combining materials, especially nanoparticulate systems, construction function-enhanced also summarized. Furthermore, foreseeable challenges future perspectives included research direction field.
Language: Английский
Citations
146
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Language: Английский
Citations
141
ACS Nano, Journal Year: 2022, Volume and Issue: 16(3), P. 3881 - 3894
Published: March 3, 2022
Tumor cells undergoing immunogenic cell death (ICD) release damage-associated molecular patterns (DAMPs) to trigger a long-term protective antitumor response. ICD can be induced by certain pathogens, chemotherapeutics, and physical modalities. In this work, we demonstrate that gaseous molecule, specifically nitric oxide (NO), induce potent effect. NO exerts cytotoxic effects are accompanied the emission of DAMPs based on endoplasmic reticulum stress mitochondrial dysfunction pathways. Released elicit immunological protection against subsequent rechallenge syngeneic tumor in immunocompetent mice. We prepare polynitrosated polyesters with high storage capacity through facile polycondensation reaction followed postsynthetic modification. The polyesters-based nanogenerator (NanoNO) enables efficient delivery controlled tumors induces sufficient different immune-intact models tumors, NanoNO exhibits significant growth suppression increases local dose signals T infiltrations, ultimately prolonging survival. addition, synergizes PD-1 blockade prevent metastasis. conclude not only is inducer for cancer immunotherapy but also it expands range inducers into field molecules.
Language: Английский
Citations
124
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114822 - 114822
Published: April 21, 2023
Central nervous system (CNS) disorders affect as many 1.5 billion people globally. The limited delivery of most imaging and therapeutic agents into the brain is a major challenge for treatment CNS disorders. With advent nanotechnologies, controlled drugs with nanoparticles holds great promise in overcoming blood-brain barrier (BBB) improving efficacy. In recent years, magnetic iron oxide (MIONPs) have stood out promising theranostic nanoplatform drug they possess unique physical properties biodegradable characteristics. this review, we summarize advances MIONP-based platforms diseases. We firstly introduce methods synthesis surface functionalization MIONPs emphasis on inclusion biocompatible polymers that allow addition tailored physicochemical properties. then discuss vivo applications using MIONPs. Finally, present perspective remaining challenges possible future directions systems.
Language: Английский
Citations
112
Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(35), P. 7063 - 7075
Published: Jan. 1, 2021
This paper reviews the recent progress in nitric oxide (NO) donors, biomaterial vectors, biomaterial-based NO delivery systems and synthetic enzyme mimics, emphasizes application potentials of releasing biomaterials chronic wound healing.
Language: Английский
Citations
111
ACS Nano, Journal Year: 2021, Volume and Issue: 15(10), P. 16076 - 16094
Published: Oct. 4, 2021
Stroke is a primary cause of death and disability worldwide, while effective safe drugs remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle-derived multifunctional nanotherapies ischemic stroke, which are engineered from pharmacologically active oligosaccharide material (termed as TPCD) prepared by covalently conjugating radical-scavenging compound (Tempol) hydrogen-peroxide-eliminating moiety phenylboronic acid pinacol ester (PBAP) on β-cyclodextrin. Of note, combined functional moieties Tempol PBAP β-cyclodextrin contribute antioxidative anti-inflammatory activities TPCD. Cellularly, TPCD nanoparticles (i.e., NPs) reduced oxygen-glucose deprivation-induced overproduction oxidative mediators, increased antioxidant enzyme expression, suppressed microglial-mediated inflammation, thereby inhibiting neuronal apoptosis. After intravenous (i.v.) delivery, NPs could efficiently accumulate at the cerebral injury site mice with middle artery occlusion (MCAO), showing considerable distribution in cells relevant pathogenesis stroke. Therapeutically, significantly decreased infarct volume accelerated recovery neurological function MCAO mice. Mechanistically, efficacy achieved antioxidative, anti-inflammatory, antiapoptotic effects. Furthermore, can reactive oxygen species labile nanovehicle load triggerably release an inflammation-resolving peptide Ac2-26, giving rise nanotherapy ATPCD NP). Compared NP, NP demonstrated notably enhanced vivo efficacies, largely resulting additional activity. Consequently, NP-derived nanomedicines further promising targeted therapies stroke other inflammation-associated cerebrovascular diseases.
Language: Английский
Citations
105
ACS Nano, Journal Year: 2022, Volume and Issue: 16(4), P. 6527 - 6540
Published: April 15, 2022
Despite considerable advancements in cell membrane-camouflaged nanocarriers to leverage natural functions, artificial that can accurately mimic both the biological and physical properties of cells are urgently needed. Herein, inspired by important effect stiffness deformability red blood (RBCs) on their life span flowing through narrow vessels, we report construction RBC RBCs at different stages study how RBC-derived affects behaviors. membrane-coated elastic poly(ethylene glycol) diacrylate hydrogel nanoparticles (RBC-ENPs) simulating dynamic exhibited high immunocompatibility with minimum immunoglobulin adsorption surface protein corona, resulting reduced opsonization macrophages ultralong circulation. Furthermore, RBC-ENPs deform like achieve excellent diffusion tumor extracellular matrix, leading improved multicellular spheroid penetration tissue accumulation. In mouse cancer models, doxorubicin-loaded demonstrated superior antitumor efficacy first-line chemotherapeutic drug PEGylated doxorubicin liposomes. Our work highlights tuning membrane-derived may offer an alternative approach for bionic design nanomedicines future.
Language: Английский
Citations
94
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Jan. 17, 2023
Thrombotic cerebro-cardiovascular diseases are the leading causes of disability and death worldwide. However, current drug therapeutics compromised by narrow therapeutic windows, unsatisfactory thrombolysis effects, severe bleeding events, high recurrence rates. In this study, we exploit a self-propelling nano-penetrator with fuel loading controllable motion features, which is molecularly co-assembled using photothermal photosensitizer (DiR) photothermal-activable NO donor (BNN6). The precisely engineered BNN6-DiR pair shows distinct advantages in terms productivity autonomous under laser irradiation. animal models artery/vein thrombosis acute ischemic stroke, self-fueled enables self-navigated thrombus-homing accumulation, self-propelled clot deep penetration, fluorescence image-guided photothermal/mechanical thrombolysis, NO-mediated prevention stroke salvage. As expected, displayed favorable outcomes without risk compared to clinically available thrombolytic drug. This study offers facile, safe, effective nonpharmaceutical modality towards clinical treatment stroke.
Language: Английский
Citations
64