Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(5), P. 188946 - 188946
Published: June 28, 2023
Language: Английский
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081
Published: Jan. 1, 2023
Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication
Language: Английский
Citations
129
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Feb. 20, 2023
Abstract The major challenges of immunotherapy for glioblastoma are that drugs cannot target tumor sites accurately and properly activate complex immune responses. Herein, we design prepare a kind chemotactic nanomotor loaded with brain endothelial cell targeting agent angiopep-2 anti-tumor drug (Lonidamine modified mitochondrial triphenylphosphine, TLND). Reactive oxygen species inducible nitric oxide synthase (ROS/iNOS), which specifically highly expressed in microenvironment, used as chemoattractants to induce the behavior nanomotors. We propose precise strategy cells-tumor cells-mitochondria. Results verified released NO TLND can regulate circulation through multiple steps enhance effect immunotherapy, including triggering immunogenic death tumor, inducing dendritic cells mature, promoting cytotoxic T infiltration, regulating microenvironment. Moreover, this treatment form an effective memory prevent metastasis recurrence.
Language: Английский
Citations
101
JACS Au, Journal Year: 2023, Volume and Issue: 3(3), P. 682 - 699
Published: Feb. 14, 2023
Photosensitizer-based photodynamic therapy (PDT) has been considered as a promising modality for fighting diverse types of cancers. PDT directly inhibits local tumors by minimally invasive strategy, but it seems to be incapable achieving complete eradication and fails prevent metastasis recurrence. Recently, increasing events proved that was associated with immunotherapy triggering immunogenic cell death (ICD). Upon specific wavelength light irradiation, the photosensitizers will turn surrounding oxygen molecules into cytotoxic reactive species (ROS) killing cancer cells. Simultaneously, dying tumor cells release tumor-associated antigens, which could improve immunogenicity activate immune However, progressively enhanced immunity is typically limited intrinsic immunosuppressive microenvironment (TME). To overcome this obstacle, immuno-photodynamic (IPDT) come one most beneficial strategies, takes advantage stimulate response unite inducing immune-OFF immune-ON ones, achieve systemic In Perspective, we provide review recent advances in organic photosensitizer-based IPDT. The general process responses triggered (PSs) how enhance antitumor pathway modifying chemical structure or conjugating targeting component discussed. addition, future perspectives challenges IPDT strategies are also We hope Perspective inspire more innovative ideas executable developments war against cancer.
Language: Английский
Citations
62
Small Methods, Journal Year: 2023, Volume and Issue: 7(5)
Published: Jan. 27, 2023
Abstract Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) immunogenic (ICD), as important mechanisms, are widely reported in cancer therapy, understanding the relationship between two is significant for clinical tumor treatments. Considering that vast nanodrugs developed to induce PCD ICD simultaneously, this review, interrelationship described using nanomedicines examples. First, an overview of patterns focus on morphological differences interconnections among them provided. Then apoptosis terms endoplasmic reticulum stress by introducing various treatments recent developments with inducible immunogenicity. Next, crosstalk non‐apoptotic (including signaling pathways introduced their through examples further illustrated. Finally, its application prospects development new nanomaterials summarized. This review believed deepen ICD, extend biomedical applications nanodrugs, promote progress therapy.
Language: Английский
Citations
49
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)
Published: April 11, 2023
Chemodynamic immunotherapy that utilizes catalysts to produce reactive oxygen species (ROS) for killing tumor cells and arousing antitumor immunity has received considerable attention. However, it is still restricted by low ROS production efficiency insufficient immune activation, due intricate redox homeostasis in the microenvironment (TME). Herein, a metalloprotein-like hybrid nanozyme (FeS@GOx) designed situ growth of (ferrous sulfide, FeS) natural enzyme (glucose oxidase, GOx) amplify cascade boosting chemodynamic immunotherapy. In FeS@GOx, GOx allows conversion endogenous glucose gluconic acid hydrogen peroxide, which provides favorable increasing peroxide subsequent Fenton reaction FeS nanozymes, thus reinforcing production. Notably, sulfide (H2 S) release activated generation-related pH decrease, can suppress activity thioredoxin reductase catalase further inhibit elimination. Thus, FeS@GOx sustainably accumulation perturb intracellular improve therapy trigger robust immunogenic cell death effective combined with checkpoint blockade. This work proposes feasible H2 S amplified strategy employing bioinspired nanozyme, providing novel pathway multi-enzyme-mediated TME modulation precise efficient
Language: Английский
Citations
48
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(6), P. 1032 - 1050.e10
Published: May 16, 2024
Total tumor clearance through immunotherapy is associated with a fully coordinated innate and adaptive immune response, but knowledge on the exact contribution of each cell subset limited. We show that therapy-induced intratumoral CD8+ T cells recruited skewed late-stage activated M1-like macrophages, which were critical for effective control in two different murine models cancer immunotherapy. The summon these macrophages into their close vicinity via CCR5 signaling. Exposure non-polarized to supernatant lysate recapitulates tumoricidal phenotype vitro. transcriptomic signature also detected similar macrophage population present human tumors coincides clinical response checkpoint inhibitors. requirement functional co-operation between effector gives warning combinations broad macrophage-targeting strategies.
Language: Английский
Citations
47
Exploration, Journal Year: 2024, Volume and Issue: 4(6)
Published: March 24, 2024
Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.
Language: Английский
Citations
40
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 365, P. 1058 - 1073
Published: Jan. 1, 2024
Language: Английский
Citations
28
Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)
Published: Feb. 21, 2024
Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.
Language: Английский
Citations
28
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(17)
Published: Jan. 2, 2024
Abstract Gas therapy, represented by nitric oxide (NO), has shown a powerful anti‐tumor effect. However, current NO therapy relies on precursors, which are often released prematurely during in vivo delivery, resulting poor targeting and obvious toxic side effects. Herein, core/shell‐structured nanocatalyst is designed prepared to catalyze the generation of tumor without introduction donor. In this system, C‐Z@CM coating octahedron Cu‐MOF with nano‐ZnO, camouflaging homologous cell membrane. After nanomedicine taken up cells, ZnO reacts situ endogenous S‐nitrosoglutathione (GSNO), highly expressed tumors, continuously stably generate NO. addition, dispersed copper ions acts as catalytic active centers Fenton‐like reaction, catalyzes H 2 O large number hydroxyl radicals ( • OH). Importantly, cascade reactive oxygen species (ROS) leads massive production more lethal nitrogen (RNS), further enhancing therapeutic Catalytic high concentrations tumor, combined ROS RNS, accompanied glutathione (GSH) depletion, achieving effective suppression.
Language: Английский
Citations
22