Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 358, P. 439 - 464

Published: May 13, 2023

Language: Английский

---

Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 28, 2023

Abstract The formation of an occlusive thrombus in the blood vessel is main culprit for numerous life-threatening cardiovascular diseases that represent leading cause morbidity and mortality worldwide. Herein, we develop a polymer nanoplatform integrates long-wavelength second near-infrared (NIR-II) photoacoustic imaging-based thrombosis detection antithrombotic activity. We design synthesize semiconducting homopolymer with strong absorption NIR-II region molecular motion boosts photothermal conversion signal. dope thermosensitive nitric oxide donor to formulate nanoplatform, on which fibrin-specific ligand functionalized ensure selective targeting. show light harvesting capability, bright signal active accumulation ability, nanoprobes are able sensitively selectively delineate thrombi. find also displays rapid efficient clot removal activity nearly complete flow restoration both carotid models low extremity arterial under trigger by integrating thrombus-localized effect on-demand release. This offers versatile approach diagnosis treatment caused various thrombotic disorders.

Language: Английский

---

Blood–Brain Barrier‐Penetrating and Lesion‐Targeting Nanoplatforms Inspired by the Pathophysiological Features for Synergistic Ischemic Stroke Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 12, 2024

Abstract Ischemic stroke is a dreadful vascular disorder that poses enormous threats to the public health. Due its complicated pathophysiological features, current treatment options after ischemic attack remains unsatisfactory. Insufficient drug delivery lesions impeded by blood–brain barrier (BBB) largely limits therapeutic efficacy of most anti‐stroke agents. Herein, inspired rapid BBB penetrability 4T1 tumor cells upon their brain metastasis and natural roles platelet in targeting injured vasculatures, bio‐derived nanojacket developed fusing cell membrane with membrane, which further clothes on surface paeonol polymetformin‐loaded liposome obtain biomimetic nanoplatforms (PP@PCL) for treatment. The designed PP@PCL could remarkably alleviate ischemia‐reperfusion injury efficiently lesion, preventing neuroinflammation, scavenging excess reactive oxygen species (ROS), reprogramming microglia phenotypes, promoting angiogenesis due synergistic mechanisms anchor characteristics stroke. As result, exerts desirable PC12 neuronal rat model stroke, significantly attenuates apoptosis, reduces infarct volume, recovers neurological functions, bringing new insights into exploiting promising strategies cerebral management.

Language: Английский

---

Platelet-derived drug delivery systems: Pioneering treatment for cancer, cardiovascular diseases, infectious diseases, and beyond

Biomaterials, Journal Year: 2024, Volume and Issue: 306, P. 122478 - 122478

Published: Jan. 21, 2024

Language: Английский

---

Gas Therapy: Generating, Delivery, and Biomedical Applications

Small Methods, Journal Year: 2024, Volume and Issue: 8(8)

Published: Jan. 9, 2024

Abstract Oxygen (O 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and ) with direct effects, dioxide (CO complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery in situ generation these gases controllable release at site disease has attracted attention to avoid risk gas poisoning improve their performance treating such cancer therapy, cardiovascular bone tissue engineering, wound healing. Stimuli‐responsive gas‐generating sources systems based biomaterials that enable on‐demand promising approaches for precise therapy. This work highlights current advances design development new generate deliver behavior. delivered biomedical applications is then discussed.

Language: Английский

---

Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles

Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)

Published: Feb. 17, 2024

Abstract Atherosclerosis, a multifaceted chronic inflammatory disease, has profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include delayed detection advanced stages, intricate assessment plaque stability, and absence efficacious therapeutic strategies. Nanotheranostic based nanotechnology offers novel paradigm for addressing these challenges by amalgamating imaging capabilities with targeted interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates theranostic applications in due to their magnetic resonance capability biosafety. This review delineates current state prospects nanoparticle‐based nanotheranostics realm atherosclerosis, including pivotal aspects development, pertinent targeting strategies involved disease pathogenesis, diagnostic roles nanoparticles. Furthermore, this provides comprehensive overview nanomedicine approaches employing nanoparticles, encompassing chemical therapy, physical stimulation biological therapy. Finally, proposes discusses associated translating innovative into clinically viable anti‐atherosclerosis In conclusion, new insights future theranostic, showcasing remarkable potential oxide‐based versatile tools battle against atherosclerosis.

Language: Английский

---

Mitochondria in brain diseases: Bridging structural-mechanistic insights into precision-targeted therapies

Published: Feb. 1, 2025

Language: Английский

---

Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment

Nano Letters, Journal Year: 2021, Volume and Issue: 21(7), P. 3033 - 3043

Published: March 23, 2021

The poor drug delivery to cerebral ischemic regions is a key challenge of stroke treatment. Inspired by the intriguing blood–brain barrier (BBB)-penetrating ability 4T1 cancer cells upon their brain metastasis, we herein designed promising biomimetic nanoplatform camouflaging succinobucol-loaded pH-sensitive polymeric nanovehicle with cell membrane (MPP/SCB), aiming promote preferential targeting lesions attenuate ischemia/reperfusion injury. In transient middle artery occlusion (tMCAO) rat models, MPP/SCB could be preferentially delivered hemisphere 4.79-fold higher than that in normal hemisphere. Moreover, produced notable enhancement microvascular reperfusion hemisphere, resulting 69.9% reduction infarct volume and showing remarkable neuroprotective effects tMCAO rats, which was superior counterpart uncamouflaged nanovehicles (PP/SCB). Therefore, this design provides target for therapy.

Language: Английский

---

Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke

Biomaterials, Journal Year: 2021, Volume and Issue: 277, P. 121111 - 121111

Published: Aug. 31, 2021

Language: Английский

---

A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing

Bioactive Materials, Journal Year: 2022, Volume and Issue: 17, P. 471 - 487

Published: Jan. 7, 2022

Effective strategy of hemostasis and promoting angiogenesis are becoming increasingly urgent in modern medicine due to millions deaths caused by tissue damage inflammation. The adhesive has been favored as an optimistic efficient path stop bleeding, while, current presents limitations on wound care or potential degradation safety clinical practice. Therefore, it is great significance construct multifunctional address the issues. Based pro-angiogenic property l-Arginine (L-Arg), this study, novel (G-DLPUs) constructed L-Arg-based degradable polyurethane (DLPU) GelMA were prepared for care. After systematic characterization, we found that G-DLPUs endowed with excellent capability shape-adaptive adhesion. Moreover, L-Arg released generation NO during verified which would enhance healing. Following vivo biocompatibility was verified, hemostatic effect damaged organ tested using a rat liver hemorrhage model, from reveals can reduce bleeding nearly 75% no obvious inflammatory cells observed around tissue. confirmed mouse full-thickness skin defect showing hydrogel significantly improves thickness newly formed dermis vascularization (CD31 staining). In summary, promising candidate act both trauma.

Language: Английский

---