International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5249 - 5249
Published: May 11, 2024
In
clinical
practice,
tissue
adhesives
have
emerged
as
an
alternative
tool
for
wound
treatments
due
to
their
advantages
in
ease
of
use,
rapid
application,
less
pain,
and
minimal
damage.
Since
most
are
designed
internal
use
or
treatments,
the
biodegradation
is
important.
To
endow
with
biodegradability,
past
few
decades,
various
biodegradable
polymers,
either
natural
polymers
(such
chitosan,
hyaluronic
acid,
gelatin,
chondroitin
sulfate,
starch,
sodium
alginate,
glucans,
pectin,
functional
proteins,
peptides)
synthetic
poly(lactic
acid),
polyurethanes,
polycaprolactone,
poly(lactic-co-glycolic
acid)),
been
utilized
develop
novel
adhesives.
Incorporated
degraded
vivo
time
under
specific
conditions,
leading
destruction
structure
further
degradation
this
review,
we
first
summarize
strategies
utilizing
Furthermore,
provide
a
symmetric
overview
used
adhesives,
focus
on
degradability
applications
these
Additionally,
challenges
perspectives
polymer-based
discussed.
We
expect
that
review
can
new
inspirations
design
biomedical
applications.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Feb. 22, 2024
Abstract
Wet-tissue
adhesives
have
long
been
attractive
materials
for
realizing
complicated
biomedical
functions.
However,
the
hydration
film
on
wet
tissues
can
generate
a
boundary,
forming
hydrogen
bonds
with
that
weaken
adhesive
strength.
Introducing
black
phosphorus
(BP)
is
believed
to
enhance
water
absorption
capacity
of
tape-type
and
effectively
eliminate
layers
between
tissue
adhesive.
This
study
reports
composite
patch
integrated
BP
nanosheets
(CPB)
wet-tissue
adhesion.
The
patch’s
improved
mechanical
properties
ensure
its
immediate
robust
adhesion
tissues.
Various
bioapplications
CPB
are
demonstrated,
such
as
rapid
hemostasis
(within
~1-2
seconds),
monitoring
physical-activity
prevention
tumour-recurrence,
all
validated
via
in
vivo
studies.
Given
good
practicability,
histocompatibility
biodegradability
CPB,
proposed
patches
hold
significant
promise
wide
range
applications.
Acta Biomaterialia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Polyurethane
(PUr)
foam
hemostatic
dressings
are
highly
effective
at
controlling
bleeding
in
traumatic
wounds,
but
their
traditionally
slow
degradation
rate
requires
dressing
removal,
which
could
result
wound
rebleeding.
Incorporating
degradable
linkages
into
the
PUr
network
can
provide
a
biodegradable
that
be
left
place
during
healing,
eliminating
rebleeding
upon
removal
and
providing
scaffolding
for
new
tissue
ingrowth
with
no
remains
of
applied
after
healing.
In
this
work,
library
foams
was
synthesized
from
monomers
based
on
hydrolytically
labile
esters
oxidatively
thioethers
using
rapid
click-chemistry
reactions.
twelve-week
vitro
study
3%
hydrogen
peroxide
0.1
M
sodium
hydroxide,
incorporation
resulted
significantly
increased
mass
loss,
offering
better
match
Changes
to
chemical,
mechanical,
thermal,
physical
properties
throughout
were
also
analyzed.
Furthermore,
had
platelet
interactions,
improve
foam-induced
clotting
more
dressing.
Overall,
healing
outcomes
wounds.
STATEMENT
OF
SIGNIFICANCE:
A
simple,
solvent-free,
synthesis
technique
developed
polythiol
use
polyurethane
synthesis.
The
incorporated
materials
tunable
rates
within
clinically-relevant
time
frames.
resulting
byproducts
cytocompatible
hemocompatible,
made
enhanced
blood
clotting,
enabling
future
as
dressings.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
17, P. 100468 - 100468
Published: Oct. 18, 2022
Uncontrolled
bleeding
remains
as
a
leading
cause
of
death
in
surgical,
traumatic,
and
emergency
situations.
Management
the
hemorrhage
development
hemostatic
materials
are
paramount
for
patient
survival.
Owing
to
their
inherent
biocompatibility,
biodegradability
bioactivity,
biopolymers
such
polysaccharides
polypeptides
have
been
extensively
researched
become
focus
next-generation
materials.
The
construction
novel
requires
in-depth
understanding
physiological
process,
fundamental
mechanisms,
effects
material
chemistry/physics.
Herein,
we
recapitulated
common
strategies
status
biopolymer-based
Furthermore,
mechanisms
various
molecular
structures
(components
chemical
modifications)
summarized
from
microscopic
perspective,
design
based
on
them
introduced.
From
macroscopic
forms
materials,
e.g.,
powder,
sponge,
hydrogel
gauze,
is
compared,
which
may
provide
an
enlightenment
optimization
hemostat
design.
It
has
also
highlighted
current
challenges
proposed
future
directions
chemistry
design,
advanced
form
clinical
application.
Nanoscale,
Journal Year:
2023,
Volume and Issue:
15(18), P. 8044 - 8083
Published: Jan. 1, 2023
Skin
patches
(SPs)
have
rapidly
advanced
to
rehabilitation,
health
monitoring,
self-powered
and
integrated
systems.
Accordingly,
design
of
nanomaterials,
flexible
substrates,
hydrogels
nanofibers
can
facilitate
the
therapeutic
application
SPs.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(3), P. 928 - 937
Published: Jan. 1, 2023
This
work
synthesizes
three
kinds
of
polyurethane
elastomers
to
verify
the
relationship
between
macroscopic
and
viscoelastic
properties
with
given
branched
factor
work.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
25, P. 101008 - 101008
Published: March 2, 2024
Massive
blood
loss
due
to
injury
is
the
leading
cause
of
prehospital
deaths
in
disasters
and
emergencies.
Hemostatic
materials
are
used
realize
rapid
hemostasis
protect
patients
from
death.
Researchers
have
designed
developed
a
variety
hemostatic
materials.
However,
addition
their
effect,
must
be
endowed
with
additional
functions
meet
practical
application
requirements
different
scenarios.
Here,
strategies
for
modifications
use
scenarios
listed:
effective
positioning
at
site
deep
narrow
wounds
stop
bleeding,
resistance
high
pressure
wound
movement
maintain
formation,
easy
removal
without
affecting
further
treatment
after
completed,
continued
function
when
retained
as
dressing
(such
antibacterial,
antiadhesion,
tissue
repair,
etc.).
The
problems
encountered
progress
researchers
will
discussed
this
review.
We
hope
provide
valuable
references
design
more
comprehensive
