Russian Journal of Physical Chemistry A, Journal Year: 2022, Volume and Issue: 96(9), P. 1849 - 1855
Published: Sept. 1, 2022
Language: Английский
New Journal of Chemistry, Journal Year: 2021, Volume and Issue: 45(12), P. 5517 - 5525
Published: Jan. 1, 2021
This work involves the synthesis of organosilanes as colorimetric sensors for detection Ag+ ions, cytotoxicity studies and antioxidant activity.
Language: Английский
Citations
33
Journal of Molecular Structure, Journal Year: 2022, Volume and Issue: 1274, P. 134507 - 134507
Published: Nov. 7, 2022
Language: Английский
Citations
19
Sustainable Chemistry and Pharmacy, Journal Year: 2022, Volume and Issue: 30, P. 100824 - 100824
Published: Sept. 30, 2022
Language: Английский
Citations
17
Advances in chemical and materials engineering book series, Journal Year: 2025, Volume and Issue: unknown, P. 155 - 202
Published: Jan. 3, 2025
Click chemistry is not a single specific reaction, but was meant to mimic nature, which also generates substances by joining small modular units. The 1,3-dipolar azide, alkyne cycloaddition (CuAAC) reaction catalyzed copper, as nearly quantitative and easy execute has emerged the leading example of “click chemistry”. Given importance triazole scaffold in medicinal chemistry, its synthesis attracted attention drug discovery development community. This book chapter will summarizes major synthetic methods currently used for preparation pharmacological significance such antifungal, antibacterial, antitubercular, anticancer, anti-inflammatory, antioxidant many more properties discussed. Furthermore, this comprise literature from 2020 till date
Language: Английский
Citations
0
Journal of Datta Meghe Institute of Medical Sciences University, Journal Year: 2025, Volume and Issue: 20(1), P. 8 - 12
Published: Jan. 1, 2025
Abstract Breast carcinoma (BCa) is the primary cause of death in women these common types estrogen-positive BCa. Endocrine treatment mainly focused on estrogen receptor-positive The concept ER-positive BCa a quickly evolving area. As result several clinical trials conducted over past 20 years Survival rates have been increased for patients with hormone-positive cancer at all stages. result, care physician will be more actively involved ongoing monitoring, treatment, and control issues linked to antihormonal therapy. purpose current research was highlight recent developments area therapy while also providing succinct summary about fundamental care.
Language: Английский
Citations
0
Heliyon, Journal Year: 2022, Volume and Issue: 8(10), P. e10836 - e10836
Published: Oct. 1, 2022
Thymol as a natural biological template can be modified chemically since the hydroxyl group makes it candidate for structural modification. Thus, this study incorporated triazole moiety on thymol and chlorination of to help improve its potency.
Language: Английский
Citations
12
RSC Advances, Journal Year: 2024, Volume and Issue: 14(13), P. 8615 - 8640
Published: Jan. 1, 2024
M1 muscarinic acetylcholine receptor (M1-AChR), a member of the G protein-coupled receptors (GPCR) family, plays crucial role in learning and memory, making it an important drug target for Alzheimer's disease (AD) schizophrenia. M1-AChR activation deactivation have shown modifying effects AD PD preclinical models, respectively. However, understanding pharmacology associated with or is complex, because low selectivity among subtypes, hampering their therapeutic applications. In this regard, we constructed two quantitative structure-activity relationship (QSAR) one agonists (total partial), other antagonists. The binding mode 59 structurally different compounds, including antagonists experimental affinity values (pKi), were analyzed employing computational molecular docking over structures M1-AChR. Furthermore, considered interaction energy (Einter), number rotatable bonds (NRB), lipophilicity (ilogP) construction QSAR model (R2 = 89.64, QLMO2 78, Qext2 79.1). For 88.44, 82, 78.1) Einter, fraction sp3 carbons fCsp3, (MlogP). Our results suggest that ligand volume determinant to establish its biological activity (agonist antagonist), causing changes energy, determining
Language: Английский
Citations
2
Current Bioactive Compounds, Journal Year: 2022, Volume and Issue: 18(10)
Published: March 8, 2022
Background: Heterocyclic compounds possess a wide variety of roles in most fields science, such as biochemistry, medicinal chemistry, veterinary products, agrochemicals, etc. Triazole, heterocycle compound, serves building block for various having multiple applications, mostly medicine. Triazole is five-membered ring containing that occur nature, found several microorganisms, fungi, and marine organisms. The triazole nucleus boon researchers with significant scope the long-term. derivatives pharmacological properties due to their ability exert non-covalent interactions, which can improve solubility bind bimolecular targets. Objective: We focused on structure-activity relationship possessing biological activities antibacterial, antifungal, anticonvulsant, antidiabetic, antimalarial, analgesic, anti-inflammatory, antioxidant, antidepressant, antitubercular, anticancer, Results: This study revealed significance certain substituents nuclei different activities. Conclusion: From this, we conclude will be lead further research drug discovery.
Language: Английский
Citations
4
Al Mustansiriyah Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 22(3), P. 65 - 81
Published: Oct. 24, 2022
This review is about 1,2,4-triazoles include their synthesis; physio-chemical properties, SAR, reactions, derivatives. Finally, biological activities with a demonstrated showing different requirements to achieve activity
Language: Английский
Citations
3
Steroids, Journal Year: 2024, Volume and Issue: 213, P. 109529 - 109529
Published: Nov. 10, 2024
Language: Английский
Citations
0