Exploring the Journey of Zinc Oxide Nanoparticles (ZnO-NPs) toward Biomedical Applications

Materials, Journal Year: 2022, Volume and Issue: 15(6), P. 2160 - 2160

Published: March 15, 2022

The field of nanotechnology is concerned with the creation and application materials having a nanoscale spatial dimensioning. Having considerable surface area to volume ratio, nanoparticles have particularly unique properties. Several chemical physical strategies been used prepare zinc oxide (ZnO-NPs). Still, biological methods using green or natural routes in various underlying substances (e.g., plant extracts, enzymes, microorganisms) can be more environmentally friendly cost-effective than and/or long run. ZnO-NPs are now being studied as antibacterial agents microscale formulations. purpose this study analyze prevalent traditional method generating ZnO-NPs, well its harmful side effects, how it might addressed utilizing an eco-friendly approach. study's primary focus on potential biomedical applications synthesized ZnO-NPs. Biocompatibility qualities improved green-synthesized over their traditionally produced counterparts, making them excellent cancer-fighting drugs. Additionally, these beneficial when combined healing processes wounds biosensing components trace small portions biomarkers linked disorders. It has also discovered that distribute sense Green-synthesized compared ones review, which shows they outstanding potent agent, related hazardous

Language: Английский

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Current Research on Zinc Oxide Nanoparticles: Synthesis, Characterization, and Biomedical Applications

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(17), P. 3066 - 3066

Published: Sept. 3, 2022

Zinc oxide nanoparticles (ZnO-NPs) have piqued the curiosity of researchers all over world due to their extensive biological activity. They are less toxic and biodegradable with capacity greatly boost pharmacophore bioactivity. ZnO-NPs most extensively used metal in electronic optoelectronics because distinctive optical chemical properties which can be readily modified by altering morphology wide bandgap. The biosynthesis using extracts therapeutic plants, fungi, bacteria, algae, etc., improves stability biocompatibility many settings, its biofabrication alters physiochemical behavior, contributing potency. As such, as an effective nanocarrier for conventional drugs cost-effectiveness benefits being biocompatible. This article covers a comprehensive review different synthesis approaches including physical, chemical, biochemical, green techniques, also emphasizes biopotency through antibacterial, antifungal, anticancer, anti-inflammatory, antidiabetic, antioxidant, antiviral, wound healing, cardioprotective Green from fungus is given special attention, particular emphasis on extraction precursors reaction conditions, characterization surface particles.

Language: Английский

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Green Synthesis of Zinc Oxide Nanoparticles Using Salvia officinalis Leaf Extract and Their Photocatalytic and Antifungal Activities

Biology, Journal Year: 2021, Volume and Issue: 10(11), P. 1075 - 1075

Published: Oct. 21, 2021

The facile bio-fabrication of zinc oxide (ZnO) nanoparticles (NPs) is described in this study using an aqueous leaf extract Salvia officinalis L. as efficient stabilizing/capping agent. Biosynthesis nanomaterials phytochemicals present the plants has received great attention and gaining significant importance a possible alternative to conventional chemical methods. properties bio-fabricated ZnONPs were examined by different techniques, such UV-visible spectroscopy, X-ray diffraction spectroscopy (XRD), energy-dispersive (EDX), Fourier transform infrared (FTIR), transmission electron microscopy (TEM), scanning (SEM), thermogravimetric/differential calorimetry analysis (TGA/DTG). photocatalytic activity was investigated against methyl orange (MO) under UV light irradiation. Under optimum experimental conditions, exhibited 92.47% degradation MO. Furthermore, antifungal determined clinical Candida albicans isolates following standard protocols broth microdilution disc diffusion assay. susceptibility assay revealed that inhibit growth all tested fungal at varying levels with MIC values ranging from 7.81 1.95 µg/mL. Insight mechanisms action appeared be originated via inhibition ergosterol biosynthesis disruption membrane integrity. Thus, it postulated have sustainable applications developing novel agents multiple drug targets. In addition, show efficiency without any catalytic loss after catalyst recycled reused times.

Language: Английский

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Green synthesis of zinc oxide nanoparticles using Sea Lavender (Limonium pruinosum L. Chaz.) extract: characterization, evaluation of anti-skin cancer, antimicrobial and antioxidant potentials

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 27, 2022

Abstract In the present study, a green, sustainable, simple and low-cost method was adopted for synthesis of ZnO NPs, first time, using aqueous extract sea lavender, Limonium pruinosum (L.) Chaz., as reducing, capping, stabilizing agent. The obtained NPs were characterized ultraviolet–visible spectroscopy (UV–VIS), Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDX), transmission (TEM), diffraction (XRD) thermogravimetric (TGA). UV–Vis spectra green synthesized showed strong absorption peak at about 370 nm. Both XRD confirmed hexagonal/cubic crystalline structure with an average size ~ 41 It is worth noting that cytotoxic effect on investigated cancer cells dose-dependent. IC 50 skin 409.7 µg/ml NPs. Also, phyto-synthesized nanoparticles exhibited potent antibacterial antifungal activity particularly against Gram negative bacteria Escherichia coli (ATCC 8739) pathogenic fungus Candida albicans 10221). Furthermore, they considerable antioxidant potential. Thus, making them promising biocompatible candidate pharmacological therapeutic applications.

Language: Английский

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Green synthesis of zinc oxide nanoparticles using Brassica oleracea var. botrytis leaf extract: Photocatalytic, antimicrobial and larvicidal activity

Chemosphere, Journal Year: 2023, Volume and Issue: 323, P. 138263 - 138263

Published: Feb. 27, 2023

Language: Английский

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Green synthesis of copper oxide nanoparticles and its efficiency in degradation of rifampicin antibiotic

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 28, 2023

In recent ages, green nanotechnology has gained attraction in the synthesis of metallic nanoparticles due to their cost-effectiveness, simple preparation steps, and environmentally-friendly. present study, copper oxide (CuO NPs) were prepared using Parthenium hysterophorus whole plant aqueous extract as a reducing, stabilizing, capping agent. The CuO NPs characterized via UV-Vis Spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), powder X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission (TEM), Dynamic Light Scattering (DLS). spectra showed surface plasmonic resonance band occur at 340 nm. FTIR analysis revealed presence secondary metabolites on NPs, with characteristic Cu-O stretching being identified 522 cm

Language: Английский

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Plant‐Based Synthesis of Zinc Oxide Nanoparticles (ZnO‐NPs) Using Aqueous Leaf Extract of Aquilegia pubiflora: Their Antiproliferative Activity against HepG2 Cells Inducing Reactive Oxygen Species and Other In Vitro Properties

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

The anti‐cancer, anti‐aging, anti‐inflammatory, antioxidant, and anti‐diabetic effects of zinc oxide nanoparticles (ZnO‐NPs) produced from aqueous leaf extract Aquilegia pubiflora were evaluated in this study. Several methods used to characterize ZnO‐NPs, including SEM, FTIR, XRD, DLS, PL, Raman, HPLC. that had a size 34.23 nm as well strong dispersion potential highly pure, spherical or elliptical form, mean nm. According FTIR HPLC studies, the flavonoids hydroxycinnamic acid derivatives successfully capped. Synthesized ZnO‐NPs water have zeta ‐18.4 mV, showing they are stable solutions. proved be toxic for HepG2 cell line showed reduced viability 23.68 ± 2.1 % after 24 hours ZnO‐NP treatment. also excellent inhibitory against enzymes acetylcholinesterase (IC 50 : 102 μ g/mL) butyrylcholinesterase 125 which involved Alzheimer’s disease. Overall, aging, diabetes, inflammation moderate response ZnO‐NPs. Given these findings, biosynthesized could good option cure deadly diseases such cancer, Alzheimer’s, other inflammatory due their anticancer efficient antioxidant properties.

Language: Английский

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In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

ACS Omega, Journal Year: 2022, Volume and Issue: 7(5), P. 4071 - 4082

Published: Jan. 27, 2022

In this work, an ecofriendly approach for biogenic production of copper oxide nanoparticles (CuO-NPs) was proposed by utilizing the

Language: Английский

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Phytofabrication of zinc oxide nanoparticles with advanced characterization and its antioxidant, anticancer, and antimicrobial activity against pathogenic microorganisms

Biomass Conversion and Biorefinery, Journal Year: 2022, Volume and Issue: 13(1), P. 417 - 430

Published: Oct. 28, 2022

Language: Английский

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A review on biogenic green synthesis of ZnO nanoparticles by plant biomass and their applications

Materials Today Communications, Journal Year: 2022, Volume and Issue: 33, P. 104747 - 104747

Published: Oct. 22, 2022

Nanobiotechnology has recently gained prominence as a fundamental branch of modern science and novel epoch in the field material researches. Due to wide range applications it attracts attention many scientists from all over world. Bionanomaterials are prepared using variety physical, chemical, biological techniques methods. Many different metal oxide nanoparticles reported be produced by systems, including bacteria, fungi, actinomycetes, yeasts, viruses, plants. Among them, biocompatible zinc (ZnO NPs), obtained through biosynthesis with aid plant-derived materials, appears highly successful way create fast, clean, non-toxic, environmentally friendly platform for production application these bionanomaterials. This review focuses on plant extract-derived ZnO NPs synthesis, special emphasis recent advances nanomaterials.

Language: Английский

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