Future Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Feb. 22, 2024
Abstract
Background
Cancer
is
a
significant
global
health
issue,
resulting
from
uncontrolled
cell
division
leading
to
abnormal
or
tissue
growth.
Traditional
chemotherapeutic
techniques
have
investigated
wide
variety
of
pharmaceutically
active
molecules
despite
their
poor
bioavailability,
quick
renal
clearance,
inconsistent
distribution,
and
unavoidable
side
effects.
Green
synthesis,
unlike
chemical
methods,
prioritizes
eco-friendliness
cost-effectiveness.
Using
natural
sources
like
plant
extracts,
it
minimizes
environmental
impact,
reduces
costs,
aligns
with
sustainability
goals.
Operating
under
milder
conditions,
consumes
less
energy
compared
traditional
approaches.
synthesis
highly
promising
efficient
method
for
producing
nanoparticles
due
its
versatility
scalability.
Main
body
Nanotechnology
making
progress
in
cancer
treatment
because
nanoparticles'
tiny
size,
large
surface
area,
adaptability,
functionality,
as
well
potential
induce
apoptotic
pathways
fast
penetration
internalization
into
cells.
Biosynthesis
metallic
using
microbe
extracts
attracting
attention
replace
toxic
chemicals
phytochemicals
that
can
act
reducing,
capping,
stabilizing
agents
improve
biocompatibility,
antitumor,
antioxidant
properties.
This
review
focuses
on
biosynthesized
anticancer
effects
breast,
prostate,
skin,
cervical,
colorectal,
lung,
liver
cancer.
Conclusion
therapy
stands
at
the
forefront
innovative
sustainable
Despite
challenges,
ongoing
research
demonstrates
biosynthesis
revolutionize
nanomedicine,
emphasizing
need
continued
exploration
collaboration
this
rapidly
advancing
field.
Overall,
offers
comprehensive
understanding
most
recent
developments
future
applications
medicine.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 768 - 768
Published: Feb. 7, 2025
Multidrug-resistant
(MDR)
Escherichia
coli
is
a
major
foodborne
pathogen
posing
critical
threat
to
public
health,
particularly
through
the
contamination
of
animal
products.
The
increasing
prevalence
and
virulence
MDR
E.
strains
underscore
urgent
need
for
alternative
antimicrobial
strategies.
This
study
aimed
synthesize
characterize
zinc
oxide
nanoparticles
(ZnO-NPs)
using
Stevia
rebaudiana
as
sustainable
capping
reducing
agent,
aligning
with
green
chemistry
principles.
Of
120
fish
samples,
74.2%
(89/120)
were
positive
contamination.
Among
identified
strains,
77.8%
(119/153)
classified
MDR.
Resistance
profiling
revealed
22
distinct
patterns,
seven
highly
resistant
virulent
selected
further
analyses.
eco-friendly
auto-combustion
synthesis
ZnO-NPs
produced
semi-spherical
hexagonal
shapes
an
average
size
ranging
from
12
25
nm.
Scanning
Electron
Microscope-Energy
Dispersive
X-ray
analysis
(SEM-EDS)
confirms
that
primarily
consist
(37.5%)
oxygen
(19.9%),
carbon
(42.6%)
indicating
process.
demonstrated
potent,
dose-dependent
antibacterial
antibiofilm
activity
against
strains.
Additionally,
mechanistic
studies
disrupt
bacterial
cell
membranes,
alter
cellular
morphology,
interfere
DNA
integrity.
These
findings
highlight
potential
promising
nanomaterial
enhancing
food
safety
addressing
growing
challenge
bacteria.
Nanotechnology Reviews,
Journal Year:
2023,
Volume and Issue:
12(1)
Published: Jan. 1, 2023
Abstract
Green
synthesis
of
zinc
oxide
(ZnO)
nanoparticles
(NPs)
using
various
plant
extracts
as
reducing
and
capping
agents
has
gained
attention
in
recent
research.
The
green
ZnO
NPs
offers
several
advantages
such
being
simple,
eco-friendly,
safe,
cost-effective,
reproducible
approach
with
high
stability.
Hence,
this
article
provides
an
overview
metal
compounds,
traditional
chemical
physical
primary
focuses
on
the
NPs.
This
study
discusses
used
proposed
mechanisms
Additionally,
it
explores
cytotoxic
green-synthesized
addresses
biomedical
applications
NPs,
including
antibacterial,
anticancer,
antidiabetic,
antioxidant,
antifungal,
antiviral,
antiparasitic,
anti-inflammatory,
wound
healing.
Moreover,
review
critically
toxicity
emphasizes
need
for
more
toxicological
studies
to
ensure
safety
facilitate
risk
assessments
management
Furthermore,
underlines
challenges
associated
translation
process
from
bench
market,
complex
time-consuming
regulatory
approval
which
requires
a
multidisciplinary
involving
scientists,
regulators,
manufacturers.
Micromachines,
Journal Year:
2023,
Volume and Issue:
14(1), P. 209 - 209
Published: Jan. 14, 2023
The
high
occurrence
of
mycological
resistance
to
conventional
antifungal
agents
results
in
significant
illness
and
death
rates
among
immunodeficient
patients.
In
addition,
the
underprivileged
therapeutic
agents,
besides
potential
toxicity
resulting
from
long
term
therapy
necessitate
fabrication
efficient
antimicrobial
combinations.
Hence,
objective
present
investigation
is
synthesize,
characterize
investigate
anticandidal
action
green
zinc
oxide
nanoparticles
(ZnO-NPs)
formulated
using
Camellia
sinensis
leaf
extract
against
three
candidal
pathogens.
eco-friendly
synthesized
ZnO-NPs
were
characterized
utilizing
different
physicochemical
methods
their
potency
was
tested
a
disk
diffusion
assay.
this
setting,
size
biofabricated
detected
transmission
electron
microscope
(TEM)
micrographs,
recording
an
average
particle
19.380
±
2.14
nm.
zeta
analysis
revealed
that
surface
charge
−4.72
mV.
biogenic
reveal
highest
activity
C.
tropicalis
strain,
demonstrating
relative
suppressive
zones
measured
at
35.16
0.13
37.87
0.24
mm
diameter
for
concentrations
50
100
μg/disk,
respectively.
Excitingly,
Candida
glabrata
showed
susceptibility
ZnO
nanomaterials
both
ZnO-NPs’
(50
μg/disk)
compared
control.
Moreover,
biosynthesized
synergistic
effectiveness
with
nystatin
terbinafine
concerned
strains.
maximum
efficiency
noticed
percentages
23.02
45.9%,
no
hemolytic
human
erythrocytes
revealing
biosafety
hemocompatibility.
Finally,
pathogens,
as
well
patterns
such
terbinafine,
emphasize
prospective
application
these
combinations
biocompatible
highly
agents.
Sustainability,
Journal Year:
2023,
Volume and Issue:
15(20), P. 14792 - 14792
Published: Oct. 12, 2023
Drought
stress
threatens
global
food
security
and
requires
creative
agricultural
solutions.
Recently,
phyto-synthesized
nanoparticles
NPs
have
garnered
attention
as
a
way
to
reduce
crop
drought.
This
extensive
research
examines
how
improve
growth
biochemistry
in
drought-stressed
situations.
The
review
begins
with
an
introduction
highlighting
the
urgency
of
addressing
challenges
posed
by
It
also
highlights
significance
synthesized
from
photosynthesis
this
context.
Its
purpose
is
underscore
importance
sustainable
farming
practices.
approach
contrasted
conventional
methods,
elucidating
ecological
economic
advantages
NPs.
discusses
nanoparticles,
including
titanium
dioxide,
iron
oxide,
gold,
silver,
copper.
In
addition,
we
their
ability
enhance
resistance.
primary
focus
elucidate
effects
on
plant
development
under
drought
stress.
Noteworthy
outcomes
encompass
improvements
seed
germination,
seedling
growth,
water
absorption,
photosynthesis,
chlorophyll
content,
activation
antioxidant
defense
mechanisms,
modulation
hormonal
responses.
These
results
potential
agents
for
enhancing
mitigating
assesses
risks
using
agriculture.
Considerations
include
non-target
organisms,
soil,
environmental
impacts.
Further
needed
determine
long-term
effects,
dangers,
benefits
Nanoparticles
offer
targeted
improving
tolerance,
outpacing
traditional
methods
ethics
balance.
Their
mechanisms
range
nutrient
delivery
molecular
regulation.
However,
impact
remains
understudied.
critical
identifying
gaps
advancing
practices
amid
scarcity.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
6(8)
Published: July 24, 2024
Abstract
In
the
recent
decade,
zinc
oxide
nanoparticles
(ZnO
NPs)
have
been
widely
explored
owing
to
their
versatile
properties
and
prodigious
demands
in
drug
delivery,
medical,
energy
storage,
cosmetics,
healthcare
sectors.
Therefore,
current
work
opts
for
an
environmentally
benign
method
prepare
ZnO
NPs.
The
leaf
extract
of
Calendula
officinalis
L.
acts
as
a
reducing
agent
metal
ions;
therefore,
research,
NPs
were
prepared
via
green
route
by
using
extract.
Furthermore,
analysed
with
different
spectroscopic
techniques
confirm
structure
stability
nanomaterials.
characterized
XRD,
FE-SEM,
FT-IR
UV–Vis
studies.
Also,
antioxidant
antimicrobial
synthesized
investigated.
XRD
result
showed
crystalline
size
28.23
nm
wurtzite
hexagonal
along
most
intense
peak
(101).
Following
preliminary
confirmations
intended
NPs,
both
big
small
agglomerated
forms
observed
which
is
often
used
determine
exterior
assembly.
Further,
results
Fourier
transform
infrared
spectroscopy
(FT-IR)
indicated
formation
pure
absorption
Zn–O
bond
between
4000
cm
−1
500
no
discernible
monitoring
range.
spectrum
revealed
two
prominent
peaks
at
355
370
band
gap
2.986
eV.
Using
1,
1-di
phenyl-2-picrylhydrazyl
(DPPH)
test,
activity
described
was
assessed.
It
demonstrated
how,
significantly
increased
scavenging
free
radicals.
could
be
seen
that
synthesis
naturally
occurring
plant
product
acting
alternate
chemical
antioxidant.
analysis
also
performed
help
disk
diffusion
where
three
multi-drug
resistant
human
pathogens
namely
Staphylococcus
aureus,
Klebsiella
pneumoniae
E.coli
used.
Zone
Inhibition
diameter
values
are
35.2
mm
±
0.9,
23.6
0.1
13.5
0.1,
respectively,
highly
effective
against
S.
aureus.
Thus,
evidence
it
superior
friendly
preparation
hence
can
utilized
various
nano-medicine
approaches.
