Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 236 - 236

Published: Jan. 10, 2023

Despite significant advances in cancer therapy over the years, its complex pathological process still represents a major health challenge when seeking effective treatment and improved healthcare. With advent of nanotechnologies, nanomedicine-based has been widely explored as promising technology able to handle requirements clinical sector. Superparamagnetic iron oxide nanoparticles (SPION) have at forefront nanotechnology development since mid-1990s, thanks their former role contrast agents for magnetic resonance imaging. Though use MRI probes discontinued due an unfavorable cost/benefit ratio, several innovative applications therapeutic tools prompted renewal interest. The unique characteristics SPION, i.e., properties enabling specific response submitted high frequency (magnetic hyperthermia) or low (magneto-mechanical therapy) alternating field, ability generate reactive oxygen species (either intrinsically activated using various stimuli), make them particularly adapted therapy. This review provides comprehensive description fundamental aspects SPION formulation highlights recent approaches regarding vivo field

Language: Английский

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Discontinuous molecular dynamics simulations in an external field: Application to two-dimensional ferrofluids

Physical review. E, Journal Year: 2025, Volume and Issue: 111(1)

Published: Jan. 7, 2025

We introduce a stochastic method for simulating the effect of an external magnetic field on coarse-grained models colloids use in discontinuous molecular dynamics (DMD) simulations. Our is illustrated with model squares two dimensions. Square-shaped particles are represented as four disks bonded together 2×2 lattice configuration to create hard colloidal geometry. Two opposite charges embedded within square mimic interactions between particles. The stochastically during DMD simulations operates by applying impulses randomly each particle. When one experiences interaction field, charge assigned new momentum specific magnitude and orientation. this equal average Maxwell-Boltzmann distribution at simulation temperature. orientation depends charge, either positive or negative, points same direction respectively. strength determined frequency which experience field. relationship derived from Newton's equation motion. performed large systems various temperatures strengths. temperature maintained constant Andersen thermostat, while simulated stochastically, described above. find that our techniques reproduce net system magnetization close agreement two-dimensional equivalent Langevin function, maintaining constant.

Language: Английский

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Directed Assembly of Magnetic Colloidal Rods in an External Field

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

In fabricating new colloid-based materials via bottom-up design, particle-particle interactions are engineered to encourage the formation of desired assemblies. One way do this is apply an external field, which orients magnetically polarized particles in field direction. External fields have advantage that they can be programmed change time (e.g., rotation or toggling), tunably shifting system away from equilibrium. Here, we a model for ferromagnetic colloidal rods simulates their phase behavior presence magnetic with constant strength and An annealing process slowly reduces temperature during molecular dynamics simulations estimate system's equilibrium configuration ground state when between dominate thermal forces. Numerous performed at various particle densities strengths. absence assemble into antiparallel configurations. When sufficiently strong, forced orient direction therefore form head-to-tail structures. The associated net moment results collective alignment all Furthermore, systems state, occupy more space than most assembled Phase diagrams predict properties rod-like switch nonmagnetic states by tuning not only but also density.

Language: Английский

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4D Printing: Technology Overview and Smart Materials Utilized

Journal of Mechatronics and Robotics, Journal Year: 2023, Volume and Issue: 7(1), P. 1 - 14

Published: Jan. 1, 2023

4D printing is a cutting-edge technology that allows for the creation of dynamic, self-assembling structures by utilizing cutting edge, newly introduced smart materials. It builds upon traditional 3D adding dimension time, allowing printed objects to change shape or behavior over time. This achieved through use materials, such as memory alloys polymers, which respond external stimuli heat moisture. These materials are engineered have specific properties can be triggered conditions temperature, humidity, light, other physical forces. enables adapt their environment and perform functions, in response temperature changes, self-assemble trigger. Overall, an exciting rapidly advancing has potential revolutionize way we design create structures. The ability time opens up new possibilities wide range applications. As continues evolve, expect see more innovative uses scientific fields architecture, aerospace, biomedical engineering demanding highly complex dynamic changing environments.

Language: Английский

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Reconfigurable Liquid‐Bodied Miniature Machines: Magnetic Control and Microrobotic Applications

Advanced Intelligent Systems, Journal Year: 2023, Volume and Issue: 6(2)

Published: May 24, 2023

Soft miniature machines demonstrate multimodal actuation and morphology change capabilities in narrow spaces smaller than their dimension. The wirelessly controlled soft‐bodied features make them promising candidates for microrobotic manipulation targeted operation a noninvasive manner. Liquid‐bodied machine offers an ultrasoft body with extreme deformability owing to its fluid nature, enabling adaptive navigation smooth contact objects environmental restrictions. Over the last decade of development, significant research progress has been achieved controlling liquid‐bodied diverse applications. Herein, overview recent results magnetic control methods applications is provided. Considering mechanisms application challenges, ferrofluid‐based, liquid metal‐based, marble‐based are mainly discussed brief discussion on droplet‐based machines. connection between highlighted detailed analysis machine–object machine–environment interactions. current challenges opportunities outlined, aiming at designing intelligent machine‐based systems promoting development small‐scale robotics.

Language: Английский

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Individual and collective manipulation of multifunctional bimodal droplets in three dimensions

Science Advances, Journal Year: 2024, Volume and Issue: 10(29)

Published: July 17, 2024

Spatiotemporally controllable droplet manipulation is vital across numerous applications, particularly in miniature robots known for their exceptional deformability. Despite notable advancements, current control methods are predominantly limited to two-dimensional (2D) deformation and motion of an individual droplet, with minimal exploration 3D collective behaviors. Here, we introduce a bimodal actuation strategy, merging magnetic optical fields, remote programmable guidance ferrofluidic droplets collectives. The field induces dipole force, prompting the formation Simultaneously, triggers isothermal changes interfacial tension through Marangoni flows, enhancing buoyancy facilitating movements droplets. Moreover, these can function autonomously as soft robots, capable transporting objects. Alternatively, when combined hydrogel shell, they assemble into jellyfish-like driven by sunlight. These findings present efficient strategy manipulation, broadening capabilities droplet-based robotics.

Language: Английский

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Synthesis, Functionalization, and Biomedical Applications of Iron Oxide Nanoparticles (IONPs)

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(11), P. 340 - 340

Published: Nov. 12, 2024

Iron oxide nanoparticles (IONPs) have garnered significant attention in biomedical applications due to their unique magnetic properties, biocompatibility, and versatility. This review comprehensively examines the synthesis methods, surface functionalization techniques, diverse of IONPs. Various chemical physical including coprecipitation, sol-gel processes, thermal decomposition, hydrothermal synthesis, sonochemical routes, are discussed detail, highlighting advantages limitations. Surface strategies, such as ligand exchange, encapsulation, silanization, explored enhance biocompatibility functionality Special emphasis is placed on role IONPs biosensing technologies, where optical properties enable advancements, surface-enhanced Raman scattering (SERS)-based biosensors, fluorescence field-effect transistor (FET) biosensors. The explores how sensitivity selectivity detecting biomolecules, demonstrating potential for point-of-care diagnostics. Additionally, resonance imaging (MRI), targeted drug delivery, tissue engineering, stem cell tracking discussed. challenges future perspectives clinical translation also addressed, emphasizing need further research optimize ensure safety efficacy medical applications. aims provide a comprehensive understanding current state both broader fields.

Language: Английский

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Removal of polymethyl methacrylate nanoplastics and silver nanoparticles by a novel ferrofluid-COF-aminated natural cotton-based hydrogel nanosorbent

Journal of Industrial and Engineering Chemistry, Journal Year: 2023, Volume and Issue: 131, P. 265 - 279

Published: Oct. 19, 2023

Language: Английский

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A comprehensive study of As(V) removal by starch-coated magnetite nano-adsorbent based on waste iron sludge

Reactive and Functional Polymers, Journal Year: 2024, Volume and Issue: 198, P. 105879 - 105879

Published: March 12, 2024

Language: Английский

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Influence of Darcy–Forchheimer $${\text{Fe}}_{3} {\text{O}}_{4}{-}{\text{CoFe}}_{2} {\text{O}}_{4}{-}{\text{H}}_{2} {\text{O}}$$ hybrid nanofluid flow with magnetohydrodynamic and viscous dissipation effects past a permeable stretching sheet: a numerical contribution

Multiscale and Multidisciplinary Modeling Experiments and Design, Journal Year: 2024, Volume and Issue: 8(1)

Published: Dec. 20, 2024

Language: Английский

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