Isolation, Identification, Activity Evaluation, and Mechanism of Action of Neuroprotective Peptides from Walnuts: A Review DOI Open Access
Li Zhang, Yuying Bai,

Zi-Shan Hong

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 4085 - 4085

Published: Sept. 21, 2023

As human life expectancy increases, the incidence of neurodegenerative diseases in older adults has increased parallel. Walnuts contain bioactive peptides with demonstrated neuroprotective effects, making them a valuable addition to diet. We here present comprehensive review various methods used prepare, isolate, purify, and identify found walnuts. further summarise different approaches currently evaluate activity these experimental settings, highlighting their potential reduce oxidative stress, neuroinflammation, promote autophagy, as well regulate gut microflora balance cholinergic system. Finally, we offer suggestions for future research concerning bioavailability improving or masking bitter taste sensory properties final products containing identified walnut ensure successful adoption functional food ingredients neurohealth promotion.

Language: Английский

Implications of Hydrogen Sulfide in Epigenetic Controlling in Neurodegenerative Diseases: A Narrative Review DOI Open Access
Kulvinder Kochar Kaur

Clinical Pathology & Research Journal, Journal Year: 2024, Volume and Issue: 8(1), P. 1 - 13

Published: Jan. 1, 2024

Previously we had have reviewed various neurodegenerative diseases (NDD), inclusive of Alzheimer’s disease (AD), Parkinson’s (PD), as well Huntington’s (HD), role hydrogen sulfide (H2 S), in treatment different cancers breast cancer, glioma, hepatocellular carcinoma along with epigenetics Diabetic Kidney Disease (DKD), pregnancy. There by the objective this review is provision an exhaustive outline present research controlling epigenetic events correlated NDD. Here conducted a narrative utilizing search engine pubmed, google scholar; web science; embase; Cochrane library MeSH terms like (NDD); ; H2 S disease; sulfide; Epigenetics; DNA methylation; Histone post-translational modifications; protein acetylation; methylation from 2000 till 2023 December date. Emerging proof has initiated unravelling facets which impacts topography followed propagation NDD AD, PD), HD. possesses capacity modulating crucial machinery for instance methylation, histone modifications noncoding RNAs influencing gene expression cellular working germane to neuronal survival, neuroinflammation, synaptic plasticity. Thus it constructed how works form imperative actor amongst close-knit network possessing probability opening innovative therapeutic arena. Although considerable work done, still lot lacunae exist on exact molecular modes plausible repercussions H2S quantities/its downstream targets. Finally isolation future directions having using

Language: Английский

Citations

1
Changes in Astroglial Water Flow in the Pre-amyloid Phase of the STZ Model of AD Dementia DOI
Vitor Gayger-Dias, L.R.A.X. de Menezes, Vanessa-Fernanda Da Silva

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(7), P. 1851 - 1862

Published: May 11, 2024

Language: Английский

Citations

1
A Comprehensive Exploration of the Multifaceted Neuroprotective Role of Cannabinoids in Alzheimer’s Disease across a Decade of Research DOI Open Access

Petros Tyrakis,

Christina Agridi,

Malamati Kourti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8630 - 8630

Published: Aug. 7, 2024

Alzheimer’s disease (AD), a progressive neurodegenerative disorder, manifests through dysregulation of brain function and subsequent loss bodily control, attributed to β-amyloid plaque deposition TAU protein hyperphosphorylation aggregation, leading neuronal death. Concurrently, similar cannabinoids the ones derived from Cannabis sativa are present in endocannabinoid system, acting receptors CB1R CB2R other related such as Trpv-1 GPR-55, being extensively investigated for AD therapy. Given limited efficacy adverse effects current available treatments, alternative approaches crucial. Therefore, this review aims identify effective natural synthetic elucidate their beneficial actions treatment. PubMed Scopus databases were queried (2014–2024) using keywords “Alzheimer’s disease” “cannabinoids”. The majority (Δ9-THC, CBD, AEA, etc.) (JWH-133, WIN55,212-2, CP55-940, included showed promise improving memory, cognition, behavioral symptoms, potentially via pathways involving antioxidant selective agonists (such BDNF/TrkB/Akt pathway) immunomodulatory (TLR4/NF-κB p65 pathway). Combining anticholinesterase properties with cannabinoid moiety may enhance therapeutic responses, addressing cholinergic deficits brains. Thus, positive outcomes vast studies discussed support further advancing clinical trials

Language: Английский

Citations

1
Recent advances in the bench-to-bedside translation of cancer nanomedicines DOI Creative Commons
Yang Liu, Yinchao Zhang, Huikai Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(1), P. 97 - 122

Published: Dec. 14, 2024

Cancer remains a complex and challenging medical problem, driving extensive research efforts. Despite significant progress in understanding its genetic molecular aspects, the quest for effective treatments continues. Nanomedicines have shown great potential revolutionizing cancer treatment by offering targeted controlled drug delivery, reducing side effects, improving patient outcomes. Accordingly, nanomedicines been focus of development clinical translation. As September 2024, search on ClinicalTrials.gov website using term "nanoparticles" revealed numerous ongoing planned trials. Motivated recent advances field, this review explores current frontier nanomedicine. supported chemotherapy, phototherapy sonodynamic therapy, nucleic acid immunotherapy. However, translating into practice has challenged interactions between nanoparticles biological systems, variable permeability retention tumors, safety concerns, difficulty achieving issues with scaling up manufacturing. Perspectives addressing these challenges are offered. Future opportunities nanomedicines, including modifying tumor microenvironment, integrating artificial intelligence big data, targeting new areas, also discussed. This underscores to revolutionize from standpoint.

Language: Английский

Citations

1
Isolation, Identification, Activity Evaluation, and Mechanism of Action of Neuroprotective Peptides from Walnuts: A Review DOI Open Access
Li Zhang, Yuying Bai,

Zi-Shan Hong

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 4085 - 4085

Published: Sept. 21, 2023

As human life expectancy increases, the incidence of neurodegenerative diseases in older adults has increased parallel. Walnuts contain bioactive peptides with demonstrated neuroprotective effects, making them a valuable addition to diet. We here present comprehensive review various methods used prepare, isolate, purify, and identify found walnuts. further summarise different approaches currently evaluate activity these experimental settings, highlighting their potential reduce oxidative stress, neuroinflammation, promote autophagy, as well regulate gut microflora balance cholinergic system. Finally, we offer suggestions for future research concerning bioavailability improving or masking bitter taste sensory properties final products containing identified walnut ensure successful adoption functional food ingredients neurohealth promotion.

Language: Английский

Citations

3