Fabrication, Physical–Chemical and Biological Characterization of Retinol-Loaded Poly(vinyl Alcohol) Electrospun Fiber Mats for Wound Healing Applications

Polymers, Journal Year: 2023, Volume and Issue: 15(12), P. 2705 - 2705

Published: June 16, 2023

Nowadays, there exists a huge interest in producing innovative, high-performance, biofunctional, and cost-efficient electrospun biomaterials based on the association of biocompatible polymers with bioactive molecules. Such materials are well-known to be promising candidates for three-dimensional biomimetic systems wound healing applications because they can mimic native skin microenvironment; however, many open questions such as interaction mechanism between dressing material remain unclear. Recently, several biomolecules were intended use combination poly(vinyl alcohol) (PVA) fiber mats improve their biological response; nevertheless, retinol, an important biomolecule, has not been combined yet PVA produce tailored biofunctional mats. Based abovementioned concept, present work reported fabrication retinol-loaded (RPFM) variable content retinol (0 ≤ Ret 25 wt.%), physical-chemical characterization. SEM results showed that exhibited diameters distribution ranging from 150 225 nm mechanical properties affected increasing concentrations. In addition, able release up 87% depending both time initial retinol. The cell culture using primary mesenchymal stem cultures proved biocompatibility RPFM confirmed by effects cytotoxicity (low level) proliferation (high rate) dose-dependent manner. Moreover, assay suggested optimal 6.25 wt.% (RPFM-1) enhanced migratory activity without altering its morphology. Accordingly, it is demonstrated fabricated below threshold 0 would appropriate system regenerative application.

Language: Английский

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Development of Mitochondria-Targeted and Quercetin-Loaded PLGA Nanoparticles for Reducing ROS Production†

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106577 - 106577

Published: Dec. 1, 2024

Language: Английский

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