Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Language: Английский
International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
The escalating threat of infectious diseases, exacerbated by antimicrobial resistance (AMR) and biofilm formation, necessitates innovative therapeutic strategies. This review presents a comprehensive exploration the potential nanoparticles synthesized from natural sources, including plant extracts, microbial products, marine compounds, as agents. These naturally derived demonstrated significant antibiofilm antivirulence effects, with specific examples revealing their capacity to reduce mass up 78% inhibit bacterial quorum sensing 65%. integration bioactive such polyphenols chitosan, facilitates nanoparticle stability enhances efficacy, while green synthesis protocols environmental risks. Notably, identifies silver using tea achieving 85% inhibition polymicrobial growth in vitro. Despite these promising results, challenges standardization scalability persist. study underscores transformative leveraging sourced sustainable alternatives conventional antimicrobials, offering quantitative insights for future application combating mono- infections.
Language: Английский
Citations
1
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 195, P. 106874 - 106874
Published: Aug. 23, 2024
Language: Английский
Citations
7
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 522 - 539
Published: Feb. 3, 2024
Biofilms are key players in the pathogenesis of most chronic infections associated with host tissue or fluids and indwelling medical devices. These hard to be treated due increased biofilms tolerance towards antibiotics comparison planktonic (or free living) cells. Despite advanced understanding their formation physiology, continue a challenge there is no standardized therapeutic approach clinical practice eradicate them. Aptamers offer distinctive properties, including excellent affinity, selectivity, stability, making them valuable tools for purposes. This review explores flexibility designability aptamers as antibiofilm drugs but, importantly, targeting diverse drug delivery systems. It highlights specific examples application species according different modes action inhibition motility adhesion, blocking quorum sensing molecules, dispersal biofilm-cells state. Moreover, it discusses limitations challenges that impaired an success use on biofilm management, well opportunities related modifications can significantly expand applicability field.
Language: Английский
Citations
6
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 470 - 470
Published: April 8, 2024
Methicillin-resistant Staphylococcus aureus (M RSA) infections, in particular biofilm-organized bacteria, remain a clinical challenge and serious health problem. Rifabutin (RFB), an antibiotic of the rifamycins class, has shown previous work excellent anti-staphylococcal activity. Here, we proposed to load RFB liposomes aiming promote accumulation at infected sites consequently enhance therapeutic potency. Two isolates MRSA, MRSA-C1 MRSA-C2, were used test developed formulations, as well positive control, vancomycin (VCM). free liposomal forms displayed high antibacterial activity, with similar potency between tested formulations. In MRSA-C1, minimal inhibitory concentrations (MIC) for Free 0.009 0.013 μg/mL, respectively. Minimum biofilm able inhibit 50% growth (MBIC50) against 0.012 0.008 Confocal microscopy studies demonstrated rapid internalization unloaded RFB-loaded bacterial matrix. murine models systemic infection, Balb/c mice treated formulations VCM 20 40 mg/kg body weight, The vivo results significant reduction burden index major organs compared Control (positive control) groups. Furthermore, dose was two fold higher than one reinforcing strategy. addition, only associated 100% survival. Globally, this study emphasizes potential nanoformulations effective safe approach MRSA infections.
Language: Английский
Citations
6
Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 819 - 819
Published: Aug. 28, 2024
Biofilm-associated infections account for a large proportion of chronic diseases and pose major health challenge. Metal nanoparticles offer new way to address this problem, by impairing microbial growth biofilm formation causing degradation existing biofilms. This review metal with antimicrobial actions included an analysis 20 years journal papers patent applications, highlighting the progress over that time. A network relevant publications showed focus on eradication single-species biofilms formed under laboratory conditions, while bibliometric growing interest in combining different types one another or antibiotics. The applications considerable time, but relatively few patents progressing be granted. Overall, profile shows intense as anti-biofilm agents is beyond confines simple models coming closer clinical application. Looking future, may provide sustainable approach combatting drug-resistant bacteria.
Language: Английский
Citations
6
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 196, P. 106957 - 106957
Published: Sept. 24, 2024
Language: Английский
Citations
6
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 191, P. 106679 - 106679
Published: May 6, 2024
Language: Английский
Citations
5
Applied Sciences, Journal Year: 2024, Volume and Issue: 14(18), P. 8137 - 8137
Published: Sept. 10, 2024
Biofilm-associated infections present a significant challenge in modern medicine, primarily due to their resilience and resistance conventional treatments. These occur when bacteria form biofilms, protective layers formed by bacterial communities, which are notoriously resistant traditional antibiotics on surfaces such as medical implants biological surfaces, making eradication with standard difficult. This leads persistent infections, imposing substantial economic burden healthcare systems. The urgency find alternative treatments is critical current methods insufficient costly. Innovative approaches, nanotechnology-based therapies, offer promising alternatives targeting biofilms more effectively reducing the need for invasive procedures. Nanocarriers hold promise fight against biofilm-associated infections. can penetrate than treatments, delivering higher concentrations of or other antimicrobial agents precisely where they needed. targeted approach not only enhances efficacy but also minimizes potential side effects. development nanocarrier-based therapies crucial overcoming limitations ultimately improving patient outcomes In this review, systems, characteristics, limitations, benefits explored address biofilms-related Additionally, biofilm evaluation models tests necessary preclinical validation these nanosystems facilitate clinical application addressed.
Language: Английский
Citations
5
Kuwait Journal of Science, Journal Year: 2024, Volume and Issue: 51(2), P. 100201 - 100201
Published: Jan. 30, 2024
Biofilm generation is a serious issue in healthcare environments for medical equipment such as dialysis treatment machines and urine catheters. Nowadays, Staphylococcus aureus, with its increasing pathogenicity resistance to broad range of antibiotics, continues pose problem various sectors worldwide. AgNPs have received much research attention due their improved antibacterial activity. The present study intended understand the factors influencing biogenic nanoparticle-mediated manipulation bacterial biofilms by aureus. nanoparticles were synthesized leaf extracts Premna serratifolia, which prominently contained bioactive components caryophyllene, neophytadiene, phytol, squalene etc., complemented synthesis silver nanocomposites. characterization was done employing UV spectroscopy, X-ray diffraction (XRD) scanning electron microscopy (SEM). biofilm inhibition analysis microtiter plate assay suggested that nanoparticle could successfully degrade up 90 % concentrations ranging from 100 500 μg/ml. fluorescence microscope surface morphology proved nanoparticle's ability inhibit adherence. Response modeling studies quadratic model Box–Behnken Design indicated inhibitory activity immensely dependent upon concentration nanoparticles, reaction time, presence stabilizers.
Language: Английский
Citations
4
International Microbiology, Journal Year: 2024, Volume and Issue: 27(5), P. 1457 - 1471
Published: Feb. 12, 2024
Language: Английский
Citations
4