Irvingia gabonensis baill. (African Mango): A comprehensive review of its ethnopharmacological significance, unveiling its long-standing history and therapeutic potential
Journal of Ethnopharmacology,
Journal Year:
2024,
Volume and Issue:
326, P. 117942 - 117942
Published: Feb. 21, 2024
Language: Английский
Advancing Profiling of Secondary Antioxidant Metabolites in Allium cepa PDO Leaf Extract: Online Comprehensive Two-Dimensional Liquid Chromatography with High-Resolution Mass Spectrometry and Pre-Column DPPH Assay
Journal of Chromatography A,
Journal Year:
2025,
Volume and Issue:
unknown, P. 465877 - 465877
Published: March 1, 2025
Language: Английский
Exploring the anti-anaphylaxis potential of natural products: A Review
Ahmed Salem Eid,
No information about this author
Eman M. Zaki,
No information about this author
Manal M. Sabry
No information about this author
et al.
Inflammopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Abstract
Allergies
are
a
common
health
issue
affecting
many
people
around
the
world,
especially
in
developed
countries.
They
occur
when
immune
system
overreacts
to
substances
that
usually
harmless.
Some
allergic
conditions
include
asthma,
sinus
infections,
skin
rashes,
food
allergies,
hay
fever,
severe
reactions,
eczema,
swelling,
and
reactions
medications
or
insect
stings.
The
causes
of
these
allergies
complex
often
linked
genetics,
which
can
lead
heightened
responses
known
as
atopy.
Throughout
history,
plant
extracts
have
been
used
for
various
purposes,
including
medicine
food.
In
addition,
their
bioactive
compounds
show
wide
range
beneficial
effects,
such
reducing
fighting
oxidative
stress,
mast
cell
stabilizers,
lowering
inflammation,
highlighting
potential
treating
conditions.
Flavonoids
phenolic
commonly
anaphylaxis
potent
anti-inflammatory
action.
This
review
aims
promote
use
natural
products
treatments
anaphylaxis.
discovery
new
drugs
derived
from
sources
holds
significant
promise
management
Language: Английский
Investigating the effect of polymerase inhibitors on cellular proliferation: Computational studies, cytotoxicity, CDK1 inhibitory potential, and LC‐MS/MS cancer cell entrapment assays
Chemical Biology & Drug Design,
Journal Year:
2024,
Volume and Issue:
103(3)
Published: March 1, 2024
Abstract
Directly
acting
antivirals
(DAAs)
are
a
breakthrough
in
the
treatment
of
HCV.
There
controversial
reports
on
their
tendency
to
induce
hepatocellular
carcinoma
(HCC)
HCV
patients.
Numerous
have
concluded
that
HCC
is
attributed
patient‐related
factors
while
others
inclined
attribute
this
as
DAA
side‐effect.
This
study
aims
investigate
effect
polymerase
inhibitor
DAAs,
especially
daclatasivir
(DLT)
cellular
proliferation
compared
ribavirin
(RBV).
The
interaction
DAAs
with
variable
cell‐cycle
proteins
was
studied
silico.
binding
affinities
multiple
targets
were
investigated
and
molecular
dynamics
assessed.
vitro
selected
candidate
DLT
cancer
cell
determined
CDK1
inhibitory
potential
evaluated.
Finally,
entrapment
candidates
assessed
by
an
in‐house
developed
validated
LC‐MS/MS
method.
results
indicated
antiviral
agents,
DLT,
may
exert
anti‐proliferative
against
lines.
showed
be
achieved
via
targets,
including
CDK1,
resulting
halting
proliferation.
exhibited
remarkable
permeability
liver
line
which
permits
adequate
targets.
In
conclusion,
reveal
cells.
These
pose
therapeutic
choice
for
patients
suffering
from
liable
development.
Language: Английский
Interactions between grapefruit juice and psychotropic medications: an update of the literature and an original case series
Expert Opinion on Drug Metabolism & Toxicology,
Journal Year:
2024,
Volume and Issue:
20(5), P. 333 - 345
Published: May 3, 2024
There
is
a
large
body
of
preclinical
data
implicating
that
grapefruit
juice
(GJ)
inhibits
many
CYP
450
isoforms.
The
potential
GJ-to-drug
high
relevance
to
clinical
psychiatry,
because
wide
range
psychotropic
medicines
undergo
metabolism
and
P-gp
transport.
Language: Английский
Phytochemical analysis and wound healing properties of Malva parviflora L. ethanolic extract
Munir Ahmad Anwar,
No information about this author
Rania A. El Gedaily,
No information about this author
Abeer Salama
No information about this author
et al.
Journal of Ethnopharmacology,
Journal Year:
2024,
Volume and Issue:
337, P. 118983 - 118983
Published: Oct. 28, 2024
Language: Английский
A Comparative GC/MS Analysis of Citrus Essential Oils: Unveiling the Potential Benefits of Herb‐Drug Interactions in Preventing Paracetamol‐Induced Hepatotoxicity
Chemistry & Biodiversity,
Journal Year:
2023,
Volume and Issue:
20(9)
Published: Aug. 21, 2023
Our
study
aimed
to
test
the
potential
of
Citrus
oils
in
protecting
against
paracetamol
(PAR)-induced
hepatotoxicity.
The
essential
Pineapple
sweet
orange
(OO),
Murcott
mandarin
(MO),
Red
grapefruit
(GO),
and
Oval
kumquat
(KO)
were
investigated
using
gas
chromatography
coupled
with
mass
spectrometry
(GC/MS).
Twenty-seven
compounds
identified,
monoterpene
hydrocarbons
being
abundant
class.
d-Limonene
had
highest
percentage
(92.98
%,
92.82
89.75
94.46
%
OO,
MO,
GO,
KO,
respectively).
Hierarchical
cluster
analysis
(HCA)
principal
components
(PCA)
revealed
that
octanal,
linalool,
germacrene
D,
d-limonene
discriminatory
metabolites
segregated
samples
into
three
distinct
clusters.
In
vitro
antioxidant
capacities
ranged
from
1.2-12.27,
1.79-5.91,
235.05-585.28
μM
Trolox
eq/mg
oil
for
2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic
(ABTS),
ferric-reducing
power
(FRAP),
oxygen
radical
absorbance
capacity
(ORAC),
respectively.
vivo,
citrus
exhibited
a
significant
reduction
alanine
transaminase
(ALT),
aspartate
(AST),
alkaline
phosphatase
(ALP),
nitric
oxide
(NO).
Additionally,
there
was
an
increase
glutathione
reductase
(GSH),
liver
architecture
nearly
normal.
Molecular
docking
good
inhibitory
interaction
cytochrome
P450
(CYP450)
isoforms
1A2,
3A4,
2E1,
binding
energies
-6.17,
-4.51,
-5.61
kcal/mol,
Language: Английский
None
Oluwaseye A. Adebajo,
No information about this author
J. Ojo,
No information about this author
Perpetual K. Adebajo
No information about this author
et al.
International Journal of Pharmaceutical Sciences and Research,
Journal Year:
2024,
Volume and Issue:
15(5)
Published: May 1, 2024
Testicular
toxicity
has
been
associated
with
long-term
paracetamol
usage.Moringa
oleifera
is
known
to
eliminate
toxins
from
organs
and
restore
functionality.This
study
seeks
ascertain
the
potency
of
moringa
in
ameliorating
paracetamol-induced
testicular
toxicity.Forty
nine
(49)
Sprague-Dawley
rats
were
randomly
assigned
into
seven
(7)
groups
composed
7
each
treated
for
5
weeks.One
group
served
as
control,
while
3
other
administered
graded
doses
paracetamol,
then
1600mg/kg
extracts
simultaneously.The
animals
sacrificed
24
hours
after
administration
last
dose
using
anaesthesia.The
testes
epididymis
harvested,
blood
was
obtained
via
ocular
puncture.The
extract
mitigated
dose-dependent
decrease
sperm
count
morphology.Paracetamol
on
hormonal
milieu
suppressed
by
treatment,
yielding
values
closer
those
control
group.The
treatment
controlled
oxidative
stress
biomarkers
their
not
variant
when
compared
only.Hypospermatogenesis
along
restoration
normal
seminiferous
tubules
interstitial
spaces
observed
paracetamolinduced
indicates
ameliorative
histological
effect
toxicity.Therefore,
use
therapy
reverses
damaging
effects
testis
male
fertility.
INTRODUCTION:A
common
drug
used
both
an
analgesic
antipyretic
1,
2
.Paracetamol
(acetaminophen)
most
popular
non-steroidal
anti-inflammatory
(NSAID)
available
over-the-counter
utilized
acute
chronic
pain
numerous
clinical
conditions
3,
4
.
Language: Английский